Molecule Details

Cc1ccncc1NC(=O)Cc1ccccc1
3-aminopyridine-like Mcule MolPort Assayed
Molecular Properties
SMILES:
Cc1ccncc1NC(=O)Cc1ccccc1
MW: 226.279
Fraction sp3: 0.14
HBA: 2
HBD: 1
Rotatable Bonds: 3
TPSA: 41.99
cLogP: 2.57122
Covalent Warhead:
Covalent Fragment: ✔️
Source
Mcule: MCULE-5408768361
Mcule Ultimate: ZYPYKQJZFJLHQJ-UHFFFAOYSA-N
MolPort: MolPort-047-314-767
Activity Data
Average Inhibition @ 20 µM - Fluorescence: 8.1878345
Average Inhibition @ 50 µM - Fluorescence: 19.47383
Average Inhibition @ 20 µM - RapidFire: -0.63
Average Inhibition @ 50 µM - RapidFire: 16.1
Relative Solubility @ 20 µM: 1.0
Relative Solubility @ 100 µM: 1.0
Order Status
Ordered: 2020-03-31
Synthesis Location: enamine
Shipped: 2020-04-17
CC(=O)Nc1cnccc1C

MAK-UNK-6435e6c2-8

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O=C(Nc1ccccc1)Nc1cccnc1

AAR-POS-d2a4d1df-11

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O=C(CC1CCCCC1)Nc1cccnc1

ALE-HEI-f28a35b5-9

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Nc1cncnc1

AAR-POS-d2a4d1df-18

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CC(NC(=O)CCl)c1cccc(Cl)c1

AAR-POS-0daf6b7e-10

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Cc1ccc(CC(=O)Nc2cnccc2C)cc1

JAN-GHE-83b26c96-11
0.698

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Cc1ccncc1NC(=O)Cc1ccc(S(N)(=O)=O)cc1

GAB-REV-70cc3ca5-20
0.655

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Cc1ccncc1NC(=O)Cc1cccc(Cl)c1

TRY-UNI-714a760b-6
0.627

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Cc1ccncc1NC(=O)Cc1cccc(O)c1

ALP-POS-95b75b4d-2
0.627

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Cc1ccncc1NC(=O)Cc1cccc(CO)c1

EDJ-MED-e58735b6-2
0.627

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Cc1ccncc1NC(=O)Cc1cccc(I)c1

JAN-GHE-83b26c96-13
0.627

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Cc1ccncc1NC(=O)Cc1cccc([S+](C)[O-])c1

DAR-DIA-0cde14eb-78
0.619

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Cc1ccncc1NC(=O)Cc1cccc(F)c1

ALP-POS-95b75b4d-1
0.617

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Cc1ccncc1NC(=O)Cc1cccc(Br)c1

JAN-GHE-83b26c96-12
0.617

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Cc1ccncc1NC(=O)Cc1ccsc1

MIH-UNI-6b9ca91a-1
0.603

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COc1cccc(CC(=O)Nc2cnccc2C)c1

EDJ-MED-e58735b6-1
0.597

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Cc1ccncc1NC(=O)Cc1cccc(C(F)(F)F)c1

JAN-GHE-83b26c96-14
0.587

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Cc1ccncc1NC(=O)Cc1cccc(C(F)(F)F)c1

DAR-DIA-0cde14eb-76
0.587

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Cc1ccncc1NC(=O)Cc1cccc(C(N)=O)c1

ANN-UNI-98d2bf15-2
0.587

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Cc1ccncc1NC(=O)Cc1cccc(C(F)(F)F)c1

ALP-POS-95b75b4d-3
0.587

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Cc1ccncc1NC(=O)Cc1cncc(Cl)c1

TRY-UNI-2eddb1ff-2
0.583

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Cc1ccncc1NC(=O)Cc1ccccc1N

ANN-UNI-98d2bf15-1
0.583

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Cc1ccncc1NC(=O)Cc1cncc(Cl)c1

EDG-MED-0da5ad92-8
0.583

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Cc1ccncc1NC(=O)Cc1cccc(C#N)c1

TRY-UNI-714a760b-20
0.578

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Cc1ccncc1NC(=O)CCl

MAK-UNK-6ca90168-26
0.577

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Cc1ccncc1NC(=O)Cc1cccc(S(N)(=O)=O)c1

EDJ-MED-e58735b6-3
0.569

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Cc1ccncc1NC(=O)Cc1cccc(C(C)(F)F)c1

DAR-DIA-0cde14eb-79
0.569

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Cc1ccncc1NC(=O)Cc1cccc(C2(C)CC2)c1

DAR-DIA-0cde14eb-1
0.561

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Cc1ccncc1NC(=O)Cc1cccc(OC(F)(F)F)c1

ANN-UNI-98d2bf15-5
0.561

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Cc1ccncc1NC(=O)Cc1cccc(C2CC2)c1

ALP-POS-95b75b4d-4
0.561

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Cc1ccncc1NC(=O)Cc1cccc(C2(F)CC2)c1

DAR-DIA-0cde14eb-2
0.552

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Cc1nnc(CC(=O)Nc2cnccc2C)s1

ALE-HEI-f28a35b5-3
0.550

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Cc1ccncc1NC(=O)CC(C)(C)c1ccccc1

BEN-DND-93268d01-13
0.548

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Cc1ccncc1NC(=O)C(C)Cc1ccccc1

BEN-DND-93268d01-14
0.548

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Cc1ccncc1NC(=O)CCc1ccccc1F

BEN-DND-93268d01-7
0.547

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Cc1ccncc1NC(=O)CC#N

ASH-SAT-43770c7d-9
0.545

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CCC(F)(F)c1cccc(CC(=O)Nc2cnccc2C)c1

DAR-DIA-0cde14eb-77
0.544

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Cc1ccncc1NC(=O)Cc1cccc(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-3
0.544

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Cc1ccncc1NC(=O)Cc1cccc(C2(I)CC2)c1

DAR-DIA-0cde14eb-4
0.544

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Cc1ccncc1NC(=O)CCCBr

ALE-HEI-f28a35b5-12
0.544

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Cc1ccncc1NC(=O)CC(C)C(C)C

MAT-POS-590ac91e-11
0.544

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Cc1ccncc1NC(=O)CC1(CO)CC1

MAT-POS-590ac91e-6
0.542

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Cc1ccncc1NC(=O)CCOC1CC1

MAT-POS-590ac91e-10
0.541

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Cc1cc(CC(=O)Nc2cnccc2C)[nH]n1

EDJ-MED-c9f55a56-1
0.541

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Cc1ccncc1NC(=O)Cc1cncc(C#N)c1

TRY-UNI-2eddb1ff-1
0.538

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Cc1ccncc1NC(=O)Cc1cnn(C2(I)CC2)c1

DAR-DIA-0cde14eb-64
0.537

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Cc1ccncc1NC(=O)Nc1ccccc1

TRY-UNI-714a760b-4
0.534

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Cc1ccncc1NC(=O)Nc1ccccc1

ALE-HEI-f28a35b5-1
0.534

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Cc1c(N)cncc1NC(=O)Cc1ccccc1

TRY-UNI-714a760b-2
0.533

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Cc1ccncc1NC(=O)CNC(=O)Cc1cccnc1

GAB-REV-70cc3ca5-13
0.531

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Cc1ccncc1NC(=O)Cc1cccc(-c2cn[nH]c2)c1

EDJ-MED-e58735b6-4
0.529

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COc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

MAT-POS-c9973a83-1
0.522

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C(N)=O)c1

RAL-THA-6b94ceba-6
0.522

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Cc1ccncc1NC(=O)Cc1cccc(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-14
0.521

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CC(=O)Nc1cnccc1C

MAK-UNK-6435e6c2-8
0.520

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CC(=O)Nc1cnccc1C

AAR-POS-d2a4d1df-3
0.520

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Cc1ccncc1NC(=O)CCCCC(=N)N

PET-SGC-6e7c5dc0-1
0.517

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Cc1ccncc1NC(=O)CCc1ccccn1

BEN-DND-93268d01-4
0.516

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Cc1ccncc1NC(=O)CCc1cccc(Cl)c1

ALP-POS-f13221e1-4
0.515

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Cc1ccncc1NC(=O)Cc1cnn(C2(C)CC2)c1

DAR-DIA-0cde14eb-61
0.515

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Cc1ccncc1NC(=O)Cc1ccc2nc[nH]c2c1

GAB-REV-70cc3ca5-18
0.514

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Cc1ccncc1NC(=O)Cc1cccc(CN2CCOCC2)c1

SAD-SAT-7d5528d9-1
0.514

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Cc1ccncc1NC(=O)CCc1cccc(F)c1

BEN-DND-93268d01-6
0.507

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Cc1ccncc1NC(=O)Cc1ccc2[nH]ncc2c1

VLA-UCB-00f2c2b3-2
0.507

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Cc1ccncc1NC(=O)Cc1cnn(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-62
0.507

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Cc1ccncc1NC(=O)Cc1cnn(C2(F)CC2)c1

DAR-DIA-0cde14eb-63
0.507

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CNC(=O)c1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-7
0.507

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(S(N)(=O)=O)c1

RAL-THA-6b94ceba-13
0.507

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Cc1ccncc1NC(=O)Cc1nc2ccccc2[nH]1

GAB-REV-70cc3ca5-9
0.507

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Cc1ccncc1NC(=O)Cc1ccccc1Cc1ccccn1

THO-SYG-cc9e9a11-1
0.507

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Cc1ccncc1NC(=O)Cc1cccc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-7
0.507

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Cc1ccncc1NC(=O)Cc1cccc(OC2CC(=O)N2)c1

BRU-LEF-c49414a7-1
0.507

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Cc1ccncc1NC(=O)Cc1nc2cccc(C)c2o1

GAB-REV-70cc3ca5-23
0.500

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Cc1ccncc1NC(=O)Cc1ccccc1-c1ccccn1

THO-SYG-cc9e9a11-2
0.500

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Cc1ccncc1NC(=O)Cc1ccc2[nH]ccc2c1

VLA-UCB-00f2c2b3-1
0.500

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Cc1ccncc1NC(=O)CC1CC2CC2C1

MAT-POS-590ac91e-23
0.500

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CC(=O)NCc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-5
0.500

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(CS(N)(=O)=O)c1

RAL-THA-6b94ceba-15
0.500

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Cc1ccncc1NC(=O)CCc1ccc(F)cc1

BEN-DND-93268d01-5
0.500

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(NS(C)(=O)=O)c1

WIL-MOD-03b86a88-5
0.493

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(CNS(C)(=O)=O)c1

RAL-THA-6b94ceba-12
0.493

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CNS(=O)(=O)c1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-14
0.493

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CNS(=O)(=O)Cc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-16
0.493

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C(C)C(N)=O)c1

WIL-MOD-03b86a88-3
0.493

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Cc1ccncc1NC(=O)CC1CC2(CC2)C1

MAT-POS-590ac91e-24
0.492

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Cc1ccncc1NC(=O)CCCCC(N)N

ALE-HEI-f28a35b5-10
0.492

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Cc1ccncc1NC(=O)CN1CCOCC1

BEN-DND-93268d01-10
0.492

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Cc1ccncc1NC(=O)C(CO)c1ccccc1

BEN-DND-93268d01-3
0.492

View
Cc1ccncc1NC(=O)Cc1cnn(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-74
0.486

View
COC(=O)NCc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-8
0.486

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(NS(N)(=O)=O)c1

WIL-MOD-03b86a88-6
0.486

View
COCC(C(=O)Nc1cnccc1C)c1ccccc1

BEN-DND-93268d01-2
0.485

View
Cc1ccncc1NC(=O)CCc1ccn[nH]1

MAT-POS-590ac91e-17
0.484

View
Cc1ccncc1NC(=O)C(C)c1ccccc1

AHN-SAT-202241f6-1
0.484

View
COC1(CC(=O)Nc2cnccc2C)CC1

MAT-POS-590ac91e-9
0.484

View
Cc1ccncc1NC(=O)CC(O)C1CC1

MAT-POS-590ac91e-7
0.484

View
Cc1ccncc1NC(=O)C(C)c1ccccc1

TRY-UNI-714a760b-17
0.484

View
O=C(Cc1ccccc1)Nc1cccnc1

SAN-PRS-52b81272-2
0.483

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(/C=C(/c2ccccc2)C(F)(F)F)c1

MAT-POS-f42f3716-8
0.481

View
Cc1ccncc1NC(=O)CN1CCN(C(=O)Nc2ccccc2)CC1

ANU-UNK-2781581f-1
0.479

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(-c2ncc[nH]2)c1

RAL-THA-6b94ceba-9
0.479

View
Cc1ccncc1NC(=O)CN1CCN(C(=O)Nc2ccccc2)CC1

RED-SAT-26a928c9-1
0.479

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C2COC2)c1

WIL-MOD-03b86a88-2
0.479

View
Cc1ccncc1NC(=O)C(F)c1ccccc1

ABI-SAT-4d06482b-1
0.476

View
Cc1ccncc1NC(=O)CC1CCCCC1

TRY-UNI-714a760b-10
0.476

View
Cc1ccncc1NC(=O)Cc1ccc(CC(=O)Nc2cnccc2C)cc1

0.857

View
Cc1ccncc1NC(=O)Cc1ccc(-c2ccccc2)cc1

0.846

View
Cc1ccncc1NC(=O)Cc1ccncc1

0.833

View
Cc1ccncc1NC(=O)CNC(=O)Cc1ccccc1

0.825

View
Cc1ccncc1NC(=O)Cc1cccnc1

0.816

View
Cc1ccc(CC(=O)Nc2cnccc2C)cc1

0.789

View
Cc1ccncc1NC(=O)CCNC(=O)Cc1ccccc1

0.786

View
Cc1ccncc1NC(=O)NNC(=O)Cc1ccccc1

0.780

View
Cc1ccncc1NC(=O)Cc1ccc(O)cc1

0.769

View
CCc1ccc(CC(=O)Nc2cnccc2C)cc1

0.769

View
Cc1ccncc1NC(=O)C(=O)NNC(=O)Cc1ccccc1

0.762

View
Cc1cccc(CC(=O)Nc2cnccc2C)c1

0.756

View
Cc1ccncc1NC(=O)CCc1ccccc1

0.750

View
Cc1ccncc1NC(=O)Cc1ccc(Cl)cc1

0.750

View
Cc1ccncc1NC(=O)Cc1ccc(F)cc1

0.750

View
Cc1ccncc1NC(=O)Cc1ccc(Br)cc1

0.750

View
Cc1ccncc1NC(=O)Cc1ccc(I)cc1

0.750

View
Cc1ccncc1NC(=O)Cc1ccc(CN)cc1

0.750

View
Cc1ccncc1NC(=O)NCCNC(=O)Cc1ccccc1

0.744

View
Cc1ccncc1NC(=O)Cc1cncnc1

0.744

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Cc1ccncc1NC(=O)Cc1c(C)cccc1C

0.744

View
Cc1ccncc1NC(=O)Cc1cccc(Br)c1

0.738

View
Cc1ccncc1NC(=O)Cc1cccc(Cl)c1

0.738

View
Cc1ccncc1NC(=O)Cc1cccc(I)c1

0.738

View
Cc1ccncc1NC(=O)Cc1ccc(-n2cccc2)cc1

0.738

View
CC(=O)c1ccc(CC(=O)Nc2cnccc2C)cc1

0.732

View
CCCc1ccc(CC(=O)Nc2cnccc2C)cc1

0.732

View
Cc1ccncc1NC(=O)Cc1cnn(-c2ccccc2)c1

0.727

View
Cc1ccncc1NC(=O)C(=O)NCCNC(=O)Cc1ccccc1

0.727

View
Cc1ccccc1CC(=O)Nc1cnccc1C

0.725

View
Cc1cc(C)cc(CC(=O)Nc2cnccc2C)c1

0.725

View
Cc1ccncc1NC(=O)Cc1cccc(F)c1

0.721

View
Cc1ccncc1NC(=O)Cc1ccc2ccccc2c1

0.721

View
COc1ccc(CC(=O)Nc2cnccc2C)cc1

0.714

View
CC(=O)Nc1ccc(CC(=O)Nc2cnccc2C)cc1

0.714

View
Cc1ccncc1NC(=O)Cc1ccc(CC(C)C)cc1

0.714

View
Cc1ccncc1NC(=O)CCCc1ccccc1

0.714

View
Cc1ccncc1NC(=O)Cc1ccccc1Br

0.714

View
Cc1ccncc1NC(=O)Cc1ccc(C(C)(C)C)cc1

0.714

View
Cc1ccncc1NC(=O)Cc1ccc(C#N)cc1

0.714

View
Cc1ccncc1NC(=O)Cc1ccc(C(N)=O)cc1

0.714

View
Cc1ccncc1NC(=O)Cc1ccc([Si](C)(C)C)cc1

0.714

View
Cc1ccncc1NC(=O)Cc1cncn1Cc1ccccc1

0.711

View
Cc1ccc(CC(=O)Nc2cnccc2C)cc1C

0.707

View
COc1cccc(CC(=O)Nc2cnccc2C)c1

0.705

View
Cc1cc(C)c(CC(=O)Nc2cnccc2C)c(C)c1

0.700

View
Cc1ccncc1NC(=O)COCc1ccccc1

0.698

View
CCCCc1ccc(CC(=O)Nc2cnccc2C)cc1

0.698

View
Cc1ccncc1NC(=O)Cc1ccc(C(F)(F)F)cc1

0.698

View
Cc1ccncc1NC(=O)CCCCc1ccccc1

0.698

View
Cc1ccncc1NC(=O)Cc1ccc(C(F)F)cc1

0.698

View
CCSc1ccc(CC(=O)Nc2cnccc2C)cc1

0.698

View
Cc1ccncc1NC(=O)Cc1ccc(S(C)=O)cc1

0.698

View
Cc1ccncc1NC(=O)CN(CC(=O)Nc1cnccc1C)Cc1ccccc1

0.698

View
Cc1ccncc1NC(=O)C(NC(=O)Cc1ccccc1)C(C)C

0.696

View
Cc1ccccc1NC(=O)Cc1ccncc1

0.692

View
Cc1ccncc1NC(=O)Cc1ccsc1

0.690

View
Cc1ccncc1NC(=O)Cc1c(Cl)cccc1Cl

0.690

View
Cc1ccncc1NC(=O)Cc1c(F)cccc1F

0.690

View
Cc1ccc(CC(=O)Nc2cnccc2C)cn1

0.690

View
CCc1ccccc1CC(=O)Nc1cnccc1C

0.690

View
Cc1cncc(CC(=O)Nc2cnccc2C)c1

0.690

View
Cc1ccncc1NC(=O)Cc1ccccc1CO

0.690

View
Cc1ccncc1NC(=O)Cc1ccc(-n2cccn2)cc1

0.689

View
COCc1cccc(CC(=O)Nc2cnccc2C)c1

0.689

View
Cc1ccncc1NC(=O)Cc1cnc2ccccc2c1

0.689

View
Cc1ccccc1NC(=O)Cc1cccnc1

0.683

View
Cc1ccncc1NC(=O)CSc1ccccc1

0.683

View
Cc1ccncc1NC(=O)Cc1ccc([N+](=O)[O-])cc1

0.682

View
CCOc1ccc(CC(=O)Nc2cnccc2C)cc1

0.682

View
Cc1ccncc1NC(=O)CN(C)Cc1ccccc1

0.682

View
Cc1ccncc1NC(=O)Cc1ccc(S(N)(=O)=O)cc1

0.682

View
CNS(=O)(=O)c1ccc(CC(=O)Nc2cnccc2C)cc1

0.682

View
Cc1ccncc1NC(=O)Cc1ccc(-n2cnnc2)cc1

0.682

View
Cc1ccncc1NC(=O)C[C@@H](N)Cc1ccccc1

0.682

View
Cc1ccncc1NC(=O)C[C@H](N)Cc1ccccc1

0.682

View
Cc1ccncc1NC(=O)CC(N)Cc1ccccc1

0.682

View
Cc1cnccc1CC(=O)Nc1cnccc1C

0.675

View
Cc1ccncc1NC(=O)Cc1ccccc1F

0.674

View
Cc1ccncc1NC(=O)Cc1ccccc1Cl

0.674

View
Cc1ccncc1NC(=O)Cc1ccccc1I

0.674

View
Cc1ccncc1NC(=O)Cc1cnn(C)c1

0.674

View
Cc1ccncc1NC(=O)Cc1ccoc1

0.674

View
Cc1ccncc1NC(=O)Cc1cncc(O)c1

0.674

View
Cc1cnccc1NC(=O)Cc1ccc(-c2ccccc2)cc1

0.674

View
Cc1ccncc1NC(=O)Cc1cccc(C(F)(F)F)c1

0.674

View
Cc1ccncc1NC(=O)Cc1cccc(C(F)F)c1

0.674

View
Cc1ccncc1NC(=O)Cc1cccc(OCCCOc2ccccc2)c1

0.673

View
Cc1ccncc1NC(=O)Cc1c(C)[nH]c2ccccc12

0.667

View
Cc1ccncc1NC(=O)Cc1ccc(OC(F)(F)F)cc1

0.667

View
Cc1ccncc1NC(=O)Cc1ccc(NC(=O)c2ccccc2I)cc1

0.667

View
Cc1ccncc1NC(=O)CCOCc1ccccc1

0.667

View
Cc1ccncc1NC(=O)COCCc1ccccc1

0.667

View
CCCC(NC(=O)Cc1ccccc1)C(=O)Nc1cnccc1C

0.667

View
Cc1ccncc1NC(=O)CCSCc1ccccc1

0.667

View
Cc1ccncc1NC(=O)CC(Cc1ccccc1)c1ccccc1

0.667

View
Cc1ccncc1NC(=O)CN(C)CCc1ccccc1

0.667

View
Cc1cnccc1NC(=O)Cc1ccc(CC(=O)Nc2ccncc2C)cc1

0.667

View
Cc1ccncc1NC(=O)NCc1ccccc1

0.667

View
Cc1ccncc1NC(=O)Cc1c(C)nn(-c2ccccc2)c1C

0.660

View

C(NC1=C(C)C=CN=C1)(=O)CC1=CC=CC=C1

1.000

View
C(NC1=C(C)C=CN=C1)(=O)CC1=CC=C(C)C=C1

0.952

View
C(NC1=C(C)C=CN=C1)(=O)CC1=CC=C(CC)C=C1

0.926

View
C(NC1=C(C)C=CN=C1)(=O)CC1=CC=C(F)C=C1

0.917

View
C(NC1=C(C)C=CN=C1)(=O)CC1C=CC=C(C)C=1

0.914

View


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