Molecule Details

Cc1ccncc1NC(=O)Cc1ccsc1
3-aminopyridine-like Enamine Mcule
Molecular Properties
SMILES:
Cc1ccncc1NC(=O)Cc1ccsc1
MW: 232.308
Fraction sp3: 0.17
HBA: 3
HBD: 1
Rotatable Bonds: 3
TPSA: 41.99
cLogP: 2.63272
Covalent Warhead:
Covalent Fragment:
Source
Enamine REAL: Z1129283352
Enamine Extended REAL: s_22____3391102____59030
Mcule Ultimate: ILEBYIHNNZYYQE-UHFFFAOYSA-N
CS(=O)(=O)NCCc1ccccc1

AAR-POS-d2a4d1df-1

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CC(=O)Nc1cnccc1C

MAK-UNK-6435e6c2-8

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COC(=O)c1ccc(S(N)(=O)=O)cc1

MAT-POS-7dfc56d9-1

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CCNc1ccc(C#N)cn1

AAR-POS-d2a4d1df-5

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OC1CCN(Cc2ccsc2)CC1

AAR-POS-d2a4d1df-7

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O=C(Nc1ccccc1)Nc1cccnc1

AAR-POS-d2a4d1df-11

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NC(=O)[C@H]1CCC[C@H]1c1ccsc1

AAR-POS-d2a4d1df-14

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Cc1ccc(CC(=O)Nc2cnccc2C)cc1

JAN-GHE-83b26c96-11
0.603

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Cc1ccncc1NC(=O)Cc1ccccc1

TRY-UNI-714a760b-5
0.603

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Cc1ccncc1NC(=O)Cc1cccc(O)c1

ALP-POS-95b75b4d-2
0.597

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Cc1ccncc1NC(=O)Cc1cncc(Cl)c1

EDG-MED-0da5ad92-8
0.556

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Cc1ccncc1NC(=O)Cc1cncc(Cl)c1

TRY-UNI-2eddb1ff-2
0.556

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Cc1nnc(CC(=O)Nc2cnccc2C)s1

ALE-HEI-f28a35b5-3
0.548

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Cc1ccncc1NC(=O)Cc1ccc(S(N)(=O)=O)cc1

GAB-REV-70cc3ca5-20
0.547

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Cc1ccncc1NC(=O)Cc1cccc(I)c1

JAN-GHE-83b26c96-13
0.547

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Cc1ccncc1NC(=O)Cc1cccc(Cl)c1

TRY-UNI-714a760b-6
0.547

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Cc1ccncc1NC(=O)Cc1cccc(CO)c1

EDJ-MED-e58735b6-2
0.547

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Cc1ccncc1NC(=O)CCl

MAK-UNK-6ca90168-26
0.545

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Cc1ccncc1NC(=O)CC#N

ASH-SAT-43770c7d-9
0.544

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Cc1ccncc1NC(=O)Cc1cccc(Br)c1

JAN-GHE-83b26c96-12
0.538

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Cc1ccncc1NC(=O)Cc1cccc(F)c1

ALP-POS-95b75b4d-1
0.538

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COc1cccc(CC(=O)Nc2cnccc2C)c1

EDJ-MED-e58735b6-1
0.522

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CCC(F)(F)c1cccc(CC(=O)Nc2cnccc2C)c1

DAR-DIA-0cde14eb-77
0.521

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Cc1ccncc1NC(=O)CCCBr

ALE-HEI-f28a35b5-12
0.517

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Cc1ccncc1NC(=O)CCCCC(=N)N

PET-SGC-6e7c5dc0-1
0.516

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Cc1cc(CC(=O)Nc2cnccc2C)[nH]n1

EDJ-MED-c9f55a56-1
0.516

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Cc1ccncc1NC(=O)Cc1cccc(C(F)(F)F)c1

DAR-DIA-0cde14eb-76
0.515

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Cc1ccncc1NC(=O)Cc1cccc(C(F)(F)F)c1

JAN-GHE-83b26c96-14
0.515

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Cc1ccncc1NC(=O)Cc1cccc(C(N)=O)c1

ANN-UNI-98d2bf15-2
0.515

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Cc1ccncc1NC(=O)Cc1cccc(C(F)(F)F)c1

ALP-POS-95b75b4d-3
0.515

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Cc1ccncc1NC(=O)Cc1cncc(C#N)c1

TRY-UNI-2eddb1ff-1
0.515

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Cc1ccncc1NC(=O)Cc1cnn(C2(C)CC2)c1

DAR-DIA-0cde14eb-61
0.514

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Cc1ccncc1NC(=O)Cc1cnn(C2(I)CC2)c1

DAR-DIA-0cde14eb-64
0.514

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Cc1ccncc1NC(=O)Cc1ccccc1N

ANN-UNI-98d2bf15-1
0.508

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Cc1ccncc1NC(=O)Cc1cccc(C#N)c1

TRY-UNI-714a760b-20
0.507

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Cc1ccncc1NC(=O)Cc1cccc(C2(F)CC2)c1

DAR-DIA-0cde14eb-2
0.507

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Cc1ccncc1NC(=O)Cc1cnn(C2(F)CC2)c1

DAR-DIA-0cde14eb-63
0.507

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Cc1ccncc1NC(=O)Cc1cnn(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-62
0.507

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COc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

MAT-POS-c9973a83-1
0.500

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O=C(Cc1ccsc1)Nc1cccnc1

DAR-DIA-842b4336-10
0.500

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C(N)=O)c1

RAL-THA-6b94ceba-6
0.500

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Cc1ccncc1NC(=O)Cc1cccc(S(N)(=O)=O)c1

EDJ-MED-e58735b6-3
0.500

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Cc1ccncc1NC(=O)Cc1cccc(C(C)(F)F)c1

DAR-DIA-0cde14eb-79
0.500

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Cc1ccncc1NC(=O)Cc1cccc([S+](C)[O-])c1

DAR-DIA-0cde14eb-78
0.500

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(CS(N)(=O)=O)c1

RAL-THA-6b94ceba-15
0.500

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CNS(=O)(=O)Cc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-16
0.493

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Cc1ccncc1NC(=O)Cc1ccc2nc[nH]c2c1

GAB-REV-70cc3ca5-18
0.493

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Cc1ccncc1NC(=O)Cc1cccc(C2CC2)c1

ALP-POS-95b75b4d-4
0.493

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Cc1ccncc1NC(=O)Cc1cccc(OC(F)(F)F)c1

ANN-UNI-98d2bf15-5
0.493

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Cc1ccncc1NC(=O)Cc1cccc(C2(C)CC2)c1

DAR-DIA-0cde14eb-1
0.493

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Cc1ccncc1NC(=O)CCSCCS(C)(=O)=O

MAK-UNK-372b0df5-3
0.493

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Cc1ccncc1NC(=O)CC1(CO)CC1

MAT-POS-590ac91e-6
0.492

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Cc1ccncc1NC(=O)CC(C)C(C)C

MAT-POS-590ac91e-11
0.492

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CC(=O)Nc1cnccc1C

AAR-POS-d2a4d1df-3
0.491

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CC(=O)Nc1cnccc1C

MAK-UNK-6435e6c2-8
0.491

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Cc1ccncc1NC(=O)Cc1cccc(-c2cn[nH]c2)c1

EDJ-MED-e58735b6-4
0.486

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Cc1ccncc1NC(=O)Cc1cnn(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-74
0.486

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CNC(=O)c1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-7
0.486

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Cc1ccncc1NC(=O)Cc1ccc2[nH]ncc2c1

VLA-UCB-00f2c2b3-2
0.486

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(S(N)(=O)=O)c1

RAL-THA-6b94ceba-13
0.486

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Cc1ccncc1NC(=O)CCc1ccn[nH]1

MAT-POS-590ac91e-17
0.485

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C2COC2)c1

WIL-MOD-03b86a88-2
0.480

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Cc1ccncc1NC(=O)Cc1cccc(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-14
0.480

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Cc1ccncc1NC(=O)Cc1ccc2[nH]ccc2c1

VLA-UCB-00f2c2b3-1
0.479

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Cc1ccncc1NC(=O)Cc1cccc(C2(I)CC2)c1

DAR-DIA-0cde14eb-4
0.479

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Cc1ccncc1NC(=O)Cc1cccc(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-3
0.479

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CC(=O)NCc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-5
0.479

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Cc1ccncc1NC(=O)CCc1ccc(F)cc1

BEN-DND-93268d01-5
0.478

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Cc1ccncc1NC(=O)CN1CCN(C)CC1

BEN-DND-93268d01-9
0.477

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COc1ccc(-c2csc(CC(=O)Nc3cnccc3C)n2)cc1

GAB-REV-70cc3ca5-15
0.473

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(CNS(C)(=O)=O)c1

RAL-THA-6b94ceba-12
0.473

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C(C)C(N)=O)c1

WIL-MOD-03b86a88-3
0.473

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(NS(C)(=O)=O)c1

WIL-MOD-03b86a88-5
0.473

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CNS(=O)(=O)c1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-14
0.473

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Cc1ccncc1NC(=O)CN1CCOCC1

BEN-DND-93268d01-10
0.470

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Cc1ccncc1NC(=O)CC1CC2(CC2)C1

MAT-POS-590ac91e-24
0.470

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Cc1ccncc1NC(=O)CCOC1CC1

MAT-POS-590ac91e-10
0.470

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Cc1ccncc1NC(=O)CCCCC(N)N

ALE-HEI-f28a35b5-10
0.470

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Cc1ccncc1NC(=O)C[C@@H]1CC[C@H](C(N)=O)[C@@H]1c1ccsc1

PET-SGC-a3e47117-1
0.468

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COC(=O)NCc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-8
0.467

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(NS(N)(=O)=O)c1

WIL-MOD-03b86a88-6
0.467

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Cc1ccncc1NC(=O)Cc1ccccc1Cc1ccccn1

THO-SYG-cc9e9a11-1
0.466

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Cc1ccncc1NC(=O)CNC(=O)Cc1cccnc1

GAB-REV-70cc3ca5-13
0.464

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COC1(CC(=O)Nc2cnccc2C)CC1

MAT-POS-590ac91e-9
0.462

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Cc1ccncc1NC(=O)CC(O)C1CC1

MAT-POS-590ac91e-7
0.462

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(-c2ncc[nH]2)c1

RAL-THA-6b94ceba-9
0.461

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Cc1ccncc1NC(=O)CCc1ccccc1F

BEN-DND-93268d01-7
0.457

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Cc1ccncc1NC(=O)CC(C)(C)c1ccccc1

BEN-DND-93268d01-13
0.456

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Cc1ccncc1NC(=O)CC(=O)N1CCN(S(=O)(=O)c2ccsc2)CC1

MAK-UNK-7264f48c-3
0.456

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(-c2cnc[nH]2)c1

RAL-THA-6b94ceba-11
0.455

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Cc1ccncc1NC(=O)Cc1cccc(CN2CCOCC2)c1

SAD-SAT-7d5528d9-1
0.455

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Cc1ccncc1NC(=O)CN1CCCCC1

BEN-DND-93268d01-11
0.455

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Cc1ccncc1NC(=O)CC1CCCCC1

EDG-MED-0da5ad92-4
0.455

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Cc1ccncc1NC(=O)CC1CCCCC1

TRY-UNI-714a760b-10
0.455

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CC(=O)Nc1ccc(NCC(=O)Nc2cnccc2C)cc1

GAB-REV-70cc3ca5-21
0.455

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Cc1ccncc1NC(=O)CC1CC2CC2C1

MAT-POS-590ac91e-23
0.455

View
Cc1ccncc1NC(=O)Cc1cc(Cl)c2c(c1)OCCO2

BAR-COM-0f94fc3d-28
0.455

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(NC23CC(C2)C3)c1

MAT-POS-e501d84c-1
0.455

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Cc1ccncc1NC(=O)CC1CCCCC1

ALE-HEI-f28a35b5-6
0.455

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OCc2cnc[nH]2)c1

RAL-THA-6b94ceba-3
0.451

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OCc2ccn[nH]2)c1

RAL-THA-6b94ceba-4
0.451

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Cc1ccncc1NC(=O)CCc1cccc(Cl)c1

ALP-POS-f13221e1-4
0.451

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CCc1cc(CC(=O)Nc2cnccc2C)cc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-6
0.450

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(-c2ccc(C)c(F)c2F)c1

MAT-POS-f42f3716-6
0.450

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Cc1ccncc1NC(=O)CCc1ccccn1

BEN-DND-93268d01-4
0.449

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Cc1ccncc1NC(=O)Cc1cccc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-7
0.449

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Cc1ccncc1NC(=O)Cc1cccc(OC2CC(=O)N2)c1

BRU-LEF-c49414a7-1
0.449

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Cc1ccncc1NC(=O)Cc1ccsc1

1.000

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Cc1cnccc1NC(=O)Cc1ccsc1

0.805

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Cc1ccncc1NC(=O)CCc1ccsc1

0.767

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Cc1ccncc1NC(=O)Cc1ccc(CC(=O)Nc2cnccc2C)cc1

0.744

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Cc1ccncc1NC(=O)CCCc1ccsc1

0.733

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CC(=O)Nc1ccncc1NC(=O)Cc1ccsc1

0.727

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Cc1ccncc1NC(=O)Cc1ccncc1

0.725

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O=C(Cc1ccsc1)Nc1cnccc1O

0.721

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Cc1cnncc1NC(=O)Cc1ccsc1

0.714

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COc1ccncc1NC(=O)Cc1ccsc1

0.711

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CSc1ccncc1NC(=O)Cc1ccsc1

0.711

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CC(C)(C)Oc1ccncc1NC(=O)Cc1ccsc1

0.696

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Cc1ccc(CC(=O)Nc2cnccc2C)cc1

0.690

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Cc1ccncc1NC(=O)Cc1cncnc1

0.690

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CCc1cnccc1NC(=O)Cc1ccsc1

0.689

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CC(=O)c1cnccc1NC(=O)Cc1ccsc1

0.689

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Cc1ccncc1NC(=O)NCc1ccsc1

0.689

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O=C(Cc1ccsc1)Nc1ccncc1Br

0.682

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O=C(Cc1ccsc1)Nc1ccncc1F

0.682

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Cc1ccc(CC(=O)Nc2cnccc2C)cn1

0.682

View
O=C(Cc1ccsc1)Nc1ccc(NC(=O)Cc2ccsc2)c2cnccc12

0.682

View
O=C(Cc1ccsc1)Nc1ccncc1I

0.682

View
O=C(Cc1ccsc1)Nc1ccncc1O

0.682

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Cc1ccc(-c2ccncc2)cc1NC(=O)Cc1ccsc1

0.681

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Cc1cscc1NC(=O)Cc1ccsc1

0.675

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Cc1ccncc1NC(=O)Cc1ccc(O)cc1

0.674

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Cc1cc(C)cc(CC(=O)Nc2cnccc2C)c1

0.674

View
Cc1ccncc1NC(=O)Cc1cccnc1

0.674

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CCc1ccc(CC(=O)Nc2cnccc2C)cc1

0.674

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Cc1ccncc1NC(=O)C(=O)NCc1ccsc1

0.674

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Cc1nccn1-c1ccncc1NC(=O)Cc1ccsc1

0.673

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Cc1ccccc1NC(=O)Cc1ccsc1

0.667

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CC(=O)Nc1ccc(CC(=O)Nc2cnccc2C)cc1

0.667

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CCC(CC)Nc1ccncc1NC(=O)Cc1ccsc1

0.667

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Cc1cnn(-c2ccncc2NC(=O)Cc2ccsc2)c1

0.660

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Cc1ccc(-c2cccnc2)cc1NC(=O)Cc1ccsc1

0.660

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O=C(Cc1ccsc1)Nc1cnccc1-c1ccccc1

0.660

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Cc1ccncc1NC(=O)N(C)Cc1ccsc1

0.660

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Cc1ccncc1NC(=O)Cc1ccc(Cl)cc1

0.659

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Cc1ccncc1NC(=O)Cc1ccc(F)cc1

0.659

View
Cc1ccncc1NC(=O)Cc1ccc(Br)cc1

0.659

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Cc1ccc(CC(=O)Nc2cnccc2C)cc1C

0.659

View
Cc1ccncc1NC(=O)Cc1ccc(I)cc1

0.659

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Cc1ccncc1NC(=O)Cc1ccc(CN)cc1

0.659

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N#Cc1cnccc1NC(=O)Cc1ccsc1

0.652

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Cc1cc(Br)ncc1NC(=O)Cc1ccsc1

0.652

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Cc1cc(Cl)ncc1NC(=O)Cc1ccsc1

0.652

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Cc1cc(C)c(CC(=O)Nc2cnccc2C)c(C)c1

0.651

View
Cc1ccncc1NC(=O)Cc1c(C)cccc1C

0.651

View
Cc1ccncc1NC(=O)C(=O)Nc1ccsc1

0.651

View
CC(C)C(=O)c1cnccc1NC(=O)Cc1ccsc1

0.646

View
Cc1cc(C(F)(F)F)ncc1NC(=O)Cc1ccsc1

0.646

View
Cc1ccncc1NC(=O)C(=O)N(C)Cc1ccsc1

0.646

View
Cc1ccncc1NC(=O)Cc1cccs1

0.644

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CC(=O)c1ccc(CC(=O)Nc2cnccc2C)cc1

0.644

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CCCc1ccc(CC(=O)Nc2cnccc2C)cc1

0.644

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Cc1cncc(CC(=O)Nc2cnccc2C)c1

0.644

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CN1CCN(c2ccncc2NC(=O)Cc2ccsc2)CC1

0.640

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CCOc1ccc(CC(=O)Nc2cnccc2C)cc1

0.638

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Cc1ccc(C)c(NC(=O)Cc2ccsc2)c1

0.636

View
O=C(Cc1ccsc1)Nc1ccncc1

0.634

View
Cc1ccncc1NC(=O)NC(C)Cc1ccsc1

0.633

View
Cc1ccncc1NC(=O)NCCCc1ccsc1

0.633

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Cc1cc(NC(=O)Cc2ccsc2)c(C)cn1

0.630

View
Cc1ccncc1NC(=O)Cc1ccc(-c2ccccc2)cc1

0.630

View
COc1ccc(CC(=O)Nc2cnccc2C)cc1

0.630

View
Cc1ccncc1NC(=O)Cc1ccc(CC(C)C)cc1

0.630

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Cc1cccc(CC(=O)Nc2cnccc2C)c1

0.630

View
Cc1ccncc1NC(=O)Cc1ccc(C(C)(C)C)cc1

0.630

View
Cc1ccncc1NC(=O)Cc1cnn(C)c1

0.630

View
Cc1ccncc1NC(=O)Cc1ccc(C#N)cc1

0.630

View
Cc1ccncc1NC(=O)Cc1ccoc1

0.630

View
Cc1ccncc1NC(=O)Cc1cncc(O)c1

0.630

View
Cc1ccncc1NC(=O)Cc1ccc(C(N)=O)cc1

0.630

View
Cc1ccncc1NC(=O)Cc1ccc([Si](C)(C)C)cc1

0.630

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Cc1cnccc1CC(=O)Nc1cnccc1C

0.628

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Cc1cscc1NC(=O)Cc1ccncc1

0.628

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Cc1ccncc1NC(=O)Cc1csc(-c2ccsc2)n1

0.627

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O=C(Cc1ccsc1)Nc1cccc2cnccc12

0.625

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O=C(Cc1ccsc1)Nc1cccc2ccncc12

0.625

View
O=C(Cc1ccsc1)Nc1ccnc2ccncc12

0.625

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Cc1ccncc1CCNC(=O)Cc1ccsc1

0.625

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Cc1ccncc1C(C)NC(=O)Cc1ccsc1

0.625

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Cc1nnccc1NC(=O)Cc1ccsc1

0.622

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Cc1ncc(NC(=O)Cc2ccsc2)c(C)n1

0.622

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O=C(Cc1ccsc1)Nc1cnccc1Oc1ccccc1

0.620

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O=C(Cc1ccsc1)Nc1cnccc1-n1cccn1

0.620

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Cc1ccncc1NC(=O)C(=O)NC(C)Cc1ccsc1

0.620

View
Cc1ccncc1NC(=O)C(=O)NCCCc1ccsc1

0.620

View
Cc1ccncc1NC(=O)C(=O)Nc1cscc1C

0.619

View
Cc1ccncc1NC(=O)Cc1ccc(Cl)c(Cl)c1

0.617

View
Cc1nc(CC(=O)Nc2cnccc2C)cs1

0.617

View
CCCCc1ccc(CC(=O)Nc2cnccc2C)cc1

0.617

View
Cc1ccncc1NC(=O)Cc1ccc(C(F)(F)F)cc1

0.617

View
Cc1ccncc1NC(=O)Cc1ccc(F)c(F)c1

0.617

View
Cc1ccncc1NC(=O)Cc1cccc(Br)c1

0.617

View
COc1cc(CC(=O)Nc2cnccc2C)cc(OC)c1

0.617

View
Cc1ccncc1NC(=O)Cc1cccc(Cl)c1

0.617

View
Cc1ccncc1NC(=O)Cc1cccc(I)c1

0.617

View
Cc1ccncc1NC(=O)Cc1ccc(-n2cccc2)cc1

0.617

View

C(NC1=C(C)C=CN=C1)(=O)CC1=CSC=C1

1.000

View
C(NC1=CN=CC(Cl)=C1C)(=O)CC1=CSC=C1

0.885

View
C(NC1=CC=CN=C1)(=O)CC1=CSC=C1

0.866

View
C(NC1=CN=CC(C#N)=C1C)(=O)CC1=CSC=C1

0.814

View
C(NC1=C(C)C(OC)=CN=C1)(=O)CC1=CSC=C1

0.807

View


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