Molecule Details

Cc1ccncc1NC(=O)Cc1cccc(C#N)c1
3-aminopyridine-like Enamine MolPort Assayed
View on Fragalysis x2572
Molecular Properties
SMILES:
Cc1ccncc1NC(=O)Cc1cccc(C#N)c1
MW: 251.289
Fraction sp3: 0.13
HBA: 3
HBD: 1
Rotatable Bonds: 3
TPSA: 65.78
cLogP: 2.4429
Covalent Warhead: ✔️
Covalent Fragment: ✔️
Source
Enamine SCR: Z1344037997
Enamine REAL: Z1344037997
Enamine Extended REAL: s_22____3391102____6586228
MolPort: MolPort-047-318-313
Activity Data
IC50 (µM) - Fluorescence: 61.3302720094334
IC50 (µM) - RapidFire: 43.8470509906189
Trypsin IC50 (µM): 99.0
pIC50 (µM) - Fluorescence 4.21232510914368
Average Inhibition @ 20 µM - Fluorescence: 33.561645
Average Inhibition @ 50 µM - Fluorescence: 58.318795
Average Inhibition @ 20 µM - RapidFire: 20.495
Average Inhibition @ 50 µM - RapidFire: 52.68
Relative Solubility @ 20 µM: 1.0
Relative Solubility @ 100 µM: 1.01
Order Status
Ordered: 2020-03-31
Synthesis Location: enamine
Shipped: 2020-04-17
N#Cc1cccc(CC(=O)Nc2cnccc2C#N)c1

SAD-SAT-24589cd1-5
0.682

View
CS(=O)(=O)c1ccncc1NC(=O)Cc1cccc(C#N)c1

SAD-SAT-24589cd1-3
0.657

View
N#Cc1cccc(CC(=O)Nc2cnccc2CN)c1

SAD-SAT-24589cd1-8
0.652

View
Cc1ccncc1NC(=O)Cc1cccc(Cl)c1

TRY-UNI-714a760b-6
0.646

View
Cc1ccncc1NC(=O)Cc1cccc(I)c1

JAN-GHE-83b26c96-13
0.646

View
Cc1ccncc1NC(=O)Cc1cccc(O)c1

ALP-POS-95b75b4d-2
0.646

View
Cc1ccncc1NC(=O)Cc1cccc(CO)c1

EDJ-MED-e58735b6-2
0.646

View
Cc1ccncc1NC(=O)Cc1cccc(F)c1

ALP-POS-95b75b4d-1
0.636

View
Cc1ccncc1NC(=O)Cc1cccc(Br)c1

JAN-GHE-83b26c96-12
0.636

View
N#Cc1cccc(CC(=O)Nc2cnccc2[N+](=O)[O-])c1

SAD-SAT-24589cd1-1
0.634

View
Cc1ccncc1NC(=O)Cc1cncc(C#N)c1

TRY-UNI-2eddb1ff-1
0.632

View
COc1cccc(CC(=O)Nc2cnccc2C)c1

EDJ-MED-e58735b6-1
0.618

View
Cc1ccncc1NC(=O)Cc1cccc(C(N)=O)c1

ANN-UNI-98d2bf15-2
0.609

View
Cc1ccncc1NC(=O)Cc1cccc(C(F)(F)F)c1

JAN-GHE-83b26c96-14
0.609

View
Cc1ccncc1NC(=O)Cc1cccc(C(F)(F)F)c1

DAR-DIA-0cde14eb-76
0.609

View
Cc1ccncc1NC(=O)Cc1cccc(C(F)(F)F)c1

ALP-POS-95b75b4d-3
0.609

View
Cc1ccncc1NC(=O)Cc1cccc(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-14
0.608

View
Cc1c(N)cncc1NC(=O)Cc1cccc(C#N)c1

TRY-UNI-714a760b-19
0.606

View
Cc1ccncc1NC(=O)Cc1cccc(C2(F)CC2)c1

DAR-DIA-0cde14eb-2
0.597

View
Cc1ccncc1NC(=O)Cc1cccc([S+](C)[O-])c1

DAR-DIA-0cde14eb-78
0.592

View
Cc1ccncc1NC(=O)Cc1cccc(C(C)(F)F)c1

DAR-DIA-0cde14eb-79
0.592

View
Cc1ccncc1NC(=O)Cc1cccc(S(N)(=O)=O)c1

EDJ-MED-e58735b6-3
0.592

View
Cc1ccncc1NC(=O)Cc1cccc(C2(I)CC2)c1

DAR-DIA-0cde14eb-4
0.589

View
Cc1ccncc1NC(=O)Cc1cccc(C2CC2)c1

ALP-POS-95b75b4d-4
0.583

View
Cc1ccncc1NC(=O)Cc1cccc(OC(F)(F)F)c1

ANN-UNI-98d2bf15-5
0.583

View
Cc1ccncc1NC(=O)Cc1cccc(C2(C)CC2)c1

DAR-DIA-0cde14eb-1
0.583

View
Cc1ccncc1NC(=O)Cc1ccccc1

TRY-UNI-714a760b-5
0.578

View
CC(=O)N1CCC(c2ccncc2NC(=O)Cc2cccc(C#N)c2)CC1

SAD-SAT-24589cd1-9
0.573

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N#Cc1cccc(CC(=O)Nc2cnccc2CN2CCOCC2)c1

SAD-SAT-24589cd1-6
0.568

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CCC(F)(F)c1cccc(CC(=O)Nc2cnccc2C)c1

DAR-DIA-0cde14eb-77
0.568

View
Cc1ccncc1NC(=O)Cc1cccc(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-3
0.568

View
N#Cc1cccc(CC(=O)Nc2cccnc2)c1

ANN-UNI-26382800-5
0.565

View
N#Cc1cccc(CC(=O)Nc2cnccc2C2CCCNC2)c1

SAD-SAT-24589cd1-10
0.561

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Cc1ccncc1NC(=O)CN(C)c1cccc(C#N)c1

GAB-REV-70cc3ca5-19
0.560

View
Cc1ccncc1NC(=O)Cc1cccc(-c2cn[nH]c2)c1

EDJ-MED-e58735b6-4
0.553

View
N#Cc1cccc(CC(=O)Nc2cnccc2CN2CCNCC2)c1

MAK-UNK-748f8b7a-6
0.549

View
Cc1ccncc1NC(=O)Cc1cccc(CN2CCOCC2)c1

SAD-SAT-7d5528d9-1
0.538

View
Cc1ccncc1NC(=O)Cc1cccc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-7
0.532

View
Cc1ccncc1NC(=O)Cc1cccc(OC2CC(=O)N2)c1

BRU-LEF-c49414a7-1
0.532

View
Cc1ccc(CC(=O)Nc2cnccc2C)cc1

JAN-GHE-83b26c96-11
0.530

View
Cc1ccncc1NC(=O)Nc1cccc(C#N)c1

TRY-UNI-714a760b-24
0.528

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Cc1ccncc1NC(=O)CC#N

ASH-SAT-43770c7d-9
0.524

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CCNc1ncc(C#N)cc1CC(=O)Nc1cnccc1C

TRY-UNI-1fd04853-1
0.519

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CCNc1ncc(C#N)cc1CC(=O)Nc1cnccc1C

PET-SGC-175e168c-1
0.519

View
Cc1ccncc1NC(=O)Cc1cncc(Cl)c1

EDG-MED-0da5ad92-8
0.514

View
Cc1ccncc1NC(=O)Cc1cncc(Cl)c1

TRY-UNI-2eddb1ff-2
0.514

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CC1COC(CO)CN1Cc1ccncc1NC(=O)Cc1cccc(C#N)c1

MAK-UNK-748f8b7a-9
0.511

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Cc1ccncc1NC(=O)Cc1ccsc1

MIH-UNI-6b9ca91a-1
0.507

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Cc1ccncc1NC(=O)Cc1cc(C#N)ccc1-c1ccccn1

THO-SYG-cc9e9a11-4
0.506

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Cc1ccncc1NC(=O)Cc1cc(C#N)cc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-3
0.506

View
Cc1ccncc1NC(=O)Cc1cc(C#N)cc(OC2CC(=O)N2)c1

TRY-UNI-2eddb1ff-6
0.506

View
Cc1cccc(CC(=O)Nc2cnccc2C#N)c1

ALP-POS-95b75b4d-9
0.500

View
Cc1ccncc1NC(=O)Cc1cc(C#N)ccc1Cc1ccccn1

THO-SYG-cc9e9a11-3
0.500

View
Cc1ccncc1NC(=O)C(C)c1cccc(C#N)c1

TRY-UNI-714a760b-22
0.500

View
Cc1ccncc1NC(=O)Cc1ccc2[nH]ncc2c1

VLA-UCB-00f2c2b3-2
0.494

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Cc1ccncc1NC(=O)Cc1ccccc1N

ANN-UNI-98d2bf15-1
0.493

View
Cc1ccncc1NC(=O)Cc1ccc2[nH]ccc2c1

VLA-UCB-00f2c2b3-1
0.487

View
Cc1ccncc1NC(=O)Cc1ccc(S(N)(=O)=O)cc1

GAB-REV-70cc3ca5-20
0.486

View
Cc1nnc(CC(=O)Nc2cnccc2C)s1

ALE-HEI-f28a35b5-3
0.486

View
Cc1ccncc1NC(=O)Cc1ccc2nc[nH]c2c1

GAB-REV-70cc3ca5-18
0.481

View
Cc1cc(CC(=O)Nc2cnccc2C)[nH]n1

EDJ-MED-c9f55a56-1
0.479

View
Cc1ccncc1NC(=O)CCl

MAK-UNK-6ca90168-26
0.476

View
Cc1ccncc1NC(=O)Cc1cnn(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-74
0.475

View
Cc1ccncc1NC(=O)CCc1cccc(F)c1

BEN-DND-93268d01-6
0.474

View
Cc1ccncc1NC(=O)CC1(C#N)CCC1

MAT-POS-590ac91e-15
0.472

View
COc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

MAT-POS-c9973a83-1
0.468

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C(N)=O)c1

RAL-THA-6b94ceba-6
0.468

View
N#Cc1ccncc1NC(=O)Cc1cccc(Cl)c1

MAK-UNK-6ca90168-23
0.467

View
Cc1ccncc1NC(=O)Cc1cc(C#N)ccc1CN1CCC(O)CC1

TRY-UNI-9f475305-1
0.466

View
CNS(=O)(=O)Cc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-16
0.463

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(NS(C)(=O)=O)c1

WIL-MOD-03b86a88-5
0.463

View
Cc1ccncc1NC(=O)Cc1cnn(C2(I)CC2)c1

DAR-DIA-0cde14eb-64
0.462

View
COC(=O)NCc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-8
0.457

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(NS(N)(=O)=O)c1

WIL-MOD-03b86a88-6
0.457

View
Cc1ccncc1NC(=O)CCCBr

ALE-HEI-f28a35b5-12
0.456

View
CNC(=O)c1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-7
0.456

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(S(N)(=O)=O)c1

RAL-THA-6b94ceba-13
0.456

View
Cc1ccncc1NC(=O)Cc1cc(C#N)ccc1CNC(=O)N1CCOCC1

PET-SGC-276eba5a-1
0.456

View
Cc1ccncc1NC(=O)CNC(=O)Cc1cccnc1

GAB-REV-70cc3ca5-13
0.453

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C2COC2)c1

WIL-MOD-03b86a88-2
0.451

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(-c2ncc[nH]2)c1

RAL-THA-6b94ceba-9
0.451

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(CS(N)(=O)=O)c1

RAL-THA-6b94ceba-15
0.450

View
CC(=O)NCc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-5
0.450

View
Cc1ccncc1NC(=N)Cc1cccc(Cl)c1

EDG-MED-0da5ad92-6
0.446

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(-c2cnc[nH]2)c1

RAL-THA-6b94ceba-11
0.446

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C(C)C(N)=O)c1

WIL-MOD-03b86a88-3
0.444

View
CNS(=O)(=O)c1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-14
0.444

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(CNS(C)(=O)=O)c1

RAL-THA-6b94ceba-12
0.444

View
Cc1ccncc1NC(=O)Cc1cnn(C2(C)CC2)c1

DAR-DIA-0cde14eb-61
0.443

View
Cc1ccncc1NC(=O)CCOC1CC1

MAT-POS-590ac91e-10
0.438

View
C#Cc1cc(CC(=O)Nc2cnccc2C)cc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-4
0.438

View
Cc1ccncc1NC(=O)Cc1cnn(C2(F)CC2)c1

DAR-DIA-0cde14eb-63
0.438

View
Cc1ccncc1NC(=O)Cc1cnn(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-62
0.438

View
Cc1ccncc1NC(=O)Cc1ccc(Cl)c(OC2CC(=O)N2)c1

RAL-THA-901e9a10-8
0.437

View
Cc1ccncc1NC(=O)CCCCC(=N)N

PET-SGC-6e7c5dc0-1
0.437

View
Cc1ccncc1NC(=O)CC1(CO)CC1

MAT-POS-590ac91e-6
0.437

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(-c2nnc[nH]2)c1

RAL-THA-6b94ceba-10
0.435

View
Cc1ccncc1NC(=O)CC(C)C(C)C

MAT-POS-590ac91e-11
0.435

View
Cc1ccncc1NC(=O)Nc1cncc(C#N)c1

CHR-SOS-363cfb78-2
0.434

View
Cc1ccncc1NC(=O)Cc1cccc2c1CNCC2

ADA-UCB-6c2cb422-4
0.434

View
CC1=CC=CC(CC(=O)NC2=CN=CC=C2C)=C1

0.656

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(Cl)=C1

0.646

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(I)=C1

0.646

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(Br)=C1

0.636

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(F)=C1

0.636

View
CC1=CC=NC=C1NC(=O)CC1=CC=C(C#N)C=C1

0.631

View
CC1=CC=NC=C1NC(=O)NCC1=CC=CC(C#N)=C1

0.620

View
COC1=CC=CC(CC(=O)NC2=CN=CC=C2C)=C1

0.618

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(OCC#N)=C1

0.616

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC([N+](=O)[O-])=C1

0.609

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(C(F)(F)F)=C1

0.609

View
CCS(=O)(=O)C1=CC=CC(CC(=O)NC2=CN=CC=C2C)=C1

0.606

View
CC1=CC=NC=C1NC(=O)C(=O)NCC1=CC=CC(C#N)=C1

0.603

View
COCC1=CC=CC(CC(=O)NC2=CN=CC=C2C)=C1

0.600

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(C(F)F)=C1

0.600

View
COC(=O)C1=CC=CC(CC(=O)NC2=CN=CC=C2C)=C1

0.600

View
CC1=CC=NC=C1NC(=O)N(C)CC1=CC=CC(C#N)=C1

0.595

View
CC1=CC=NC=C1NC(=O)CC1=CC(OC(C)C)=CC=C1

0.592

View
CC1=CC=NC=C1NC(=O)NCCC1=CC=CC(C#N)=C1

0.587

View
CC1=CC=C(CC(=O)NC2=CN=CC=C2C)C=C1C

0.585

View
CC1=CC=NC=C1NC(=O)COC1=CC=CC(C#N)=C1

0.583

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(C2CC2)=C1

0.583

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(OC(F)(F)F)=C1

0.583

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(NS(C)(=O)=O)=C1

0.583

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(OC(F)F)=C1

0.583

View
CC1=CC=NC=C1NC(=O)C1=CC=CC(C#N)=C1

0.580

View
CC1=CC=NC=C1NC(=O)C(=O)N(C)CC1=CC=CC(C#N)=C1

0.579

View
CC1=CC=NC=C1NC(=O)CC1=CC=CN=C1

0.578

View
CC1=CC=NC=C1NC(=O)CC1=CC=C(CC(=O)NC2=CN=CC=C2C)C=C1

0.574

View
CC1=CC=NC=C1NC(=O)C(=O)NCCC1=CC=CC(C#N)=C1

0.571

View
CCCOC1=CC=CC(CC(=O)NC2=CN=CC=C2C)=C1

0.568

View
CC1=CC=C(CC(=O)NC2=CN=CC=C2C)C=C1O

0.567

View
CC1=CC=C(CC(=O)NC2=CN=CC=C2C)C=C1Br

0.567

View
CC1=CC=NC=C1NC(=O)CC1=CC=C2C=CC=CC2=C1

0.563

View
COCCOC1=CC=CC(CC(=O)NC2=CN=CC=C2C)=C1

0.560

View
CC1=CC=NC=C1NC(=O)CC1=CC=C(Cl)C(Cl)=C1

0.559

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(OCC2CC2)=C1

0.558

View
C=CCN(CC1=CC=CC(C#N)=C1)C(=O)NC1=CN=CC=C1C

0.557

View
CNC(=O)COC1=CC=CC(CC(=O)NC2=CN=CC=C2C)=C1

0.553

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(OCC(F)(F)F)=C1

0.553

View
CC1=CC=NC=C1NC(=O)CCCCOC1=CC=CC(C#N)=C1

0.551

View
CC1=CC=NC=C1NCC1=CC=CC(C#N)=C1

0.551

View
CC1=CC=NC=C1NC(=O)CC1=CC=C(F)C(F)=C1

0.551

View
CC1=CC=NC=C1NC(=O)CC1=CC=NC=C1

0.547

View
CC1=CC(C)=CC(CC(=O)NC2=CN=CC=C2C)=C1

0.545

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(NC(=O)OC(C)(C)C)=C1

0.545

View
CC(C)=CCOC1=CC=CC(CC(=O)NC2=CN=CC=C2C)=C1

0.545

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(OCCCOC2=CC=CC=C2)=C1

0.544

View
CCCCN(CC1=CC=CC(C#N)=C1)C(=O)NC1=CN=CC=C1C

0.543

View
C=CCN(CC1=CC=CC(C#N)=C1)C(=O)C(=O)NC1=CN=CC=C1C

0.543

View
COC1=CC(CC(=O)NC2=CN=CC=C2C)=CC=C1C

0.543

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(OCC2=CC=CN=C2)=C1

0.532

View
CC1=CC=C(CC(=O)NC2=CN=CC=C2C)C=C1

0.530

View
CC1=CC=NC=C1NC(=O)CC1=CN=CN=C1

0.530

View
CC1=CC=NC=C1NC(=O)CCC1=CC=C(C#N)C=C1

0.528

View
CC1=CC=NC=C1NC(=O)CC1=CC=C(C)C([N+](=O)[O-])=C1

0.528

View
CC1=CC(OCC2=CC=CC(C#N)=C2)=CC=C1NC(=O)C(=O)NC1=CN=CC=C1C

0.524

View
CC1=CC=NC=C1NC(=O)CC1=C(C)C=CC=C1C

0.522

View
CC1=CC=NC=C1NC(=O)CC1=CC=C(O)C=C1

0.522

View
CCC1=CC=C(CC(=O)NC2=CN=CC=C2C)C=C1

0.522

View
CC1=CC=NC=C1NC(=O)CC1=C(Cl)C=CC=C1Cl

0.522

View
CC1=CN=CC(CC(=O)NC2=CN=CC=C2C)=C1

0.522

View
CC1=CC=CC(COC2=CC=CC(CC(=O)NC3=CN=CC=C3C)=C2)=C1

0.519

View
CC1=CC=CC=C1COC1=CC=CC(CC(=O)NC2=CN=CC=C2C)=C1

0.519

View
CC1=CC=NC=C1NC(=O)C(=O)NC1=CC=C(OCC2=CC=CC(C#N)=C2)C=C1

0.518

View
CC1=CC=NC=C1NC(=O)CCC1=CC=CC(CCC(=O)NC2=CN=CC=C2C)=C1

0.514

View
CC1=CC=NC=C1NC(=O)CC1=CN=CC(O)=C1

0.514

View
CC1=CC=NC=C1NC(=O)C1(C2=CC=CC(C#N)=C2)CC1

0.506

View
CC1=CC=NC=C1NC(=O)NC(C)C1=CC=CC(C#N)=C1

0.506

View
CC1=CC=NC=C1NC(=O)CC1=CC=CC(OCC2=CC=CC(Cl)=C2)=C1

0.506

View
CC1=CC=NC=C1NC(=O)NC1CCN(CC2=CC=CC(C#N)=C2)CC1

0.506

View
CC1=CC=NC=C1NC(=O)C(=O)NC1=CC=CC(OCC2=CC=CC(C#N)=C2)=C1

0.506

View
CC1=CC=NC=C1NC(=O)NNC(=O)C1=CC=CC(C#N)=C1

0.500

View
CC1=CC=NC=C1NC(=O)CC1=C(F)C=CC=C1F

0.500

View
CC1=CC=NC=C1NC(=O)CC1=CC=C(C2=CC=CC=C2)C=C1

0.500

View
CC1=CC=NC=C1NC(=O)C(=O)NC1CCN(CC2=CC=CC(C#N)=C2)CC1

0.494

View
CC1=CC=NC=C1NC(=O)NNC1=CC=CC(C#N)=C1

0.494

View
CC1=CC=NC=C1NC(=O)CNC(=O)CC1=CC=CC(F)=C1

0.494

View
CC1=CC(C)=C(CC(=O)NC2=CN=CC=C2C)C(C)=C1

0.493

View
CC1=CC=NC=C1NC(=O)C(=O)NNC(=O)C1=CC=CC(C#N)=C1

0.487

View
CC1=CN=CC=C1CC(=O)NCC1=CC=CC(C#N)=C1

0.487

View
CC1=CC=NC=C1NC(=O)C1=CC=CC(COC2=CC=CC(C#N)=C2)=C1

0.483

View
CC1=CC=NC=C1NC(=O)C(=O)NNC1=CC=CC(C#N)=C1

0.481

View
CC1=CC=NC=C1NC(=O)CSC1=CC=C(C#N)C=C1

0.480

View
CC1=CC=NC=C1C(=O)NCC1=CC=CC(C#N)=C1

0.474

View
CC1=CC=C(C#N)C=C1NC(=O)CC1=CC=CN=C1

0.473

View
CC1=CC(OCC2=CC=CC(C#N)=C2)=CC=C1NC(=O)CC1=CC=CN=C1

0.465

View
CC1=CC=CC(CC(=O)NC2=CC(C#N)=CC=C2C)=C1

0.459

View
CC1=CC=C(C#N)C=C1NC(=O)CC1=CC=CC(Cl)=C1

0.459

View
CC1=CN=CC=C1NC(=O)NCC1=CC=CC(C#N)=C1

0.456

View
CC1=CC=CC(CC(=O)NC2=CC=NC=C2C#N)=C1

0.455

View
CC1=CC(OCC2=CC=CC(C#N)=C2)=CC=C1NC(=O)CC1=CC=NC=C1

0.453

View
CC1=CC=C(C#N)C=C1NC(=O)CC1=CC=CC(Br)=C1

0.453

View
CC1=CC=C(C#N)C=C1NC(=O)CC1=CC=CC(I)=C1

0.453

View
CC1=CC=C(C#N)C=C1NC(=O)CC1=CC=CC(F)=C1

0.447

View
CC1=CC=CC(CC(=O)NC2=CC=NC=C2C)=C1

0.438

View
CC1=CC=C(C#N)C=C1NC(=O)CC1=CC=CC(OCC2=CC=CN=C2)=C1

0.438

View
CC1=CC=C(C#N)C=C1NC(=O)CC1=CC=NC=C1

0.432

View
CNC1=CC=C(C#N)C=C1NC(=O)CC1=CC=CN=C1

0.429

View
CC1=CN=CC=C1NC(=O)CC1=CC=C(C#N)C=C1

0.413

View
Cc1ccncc1NC(=O)Cc1cccc(c1)C#N

1.000

View
Cc1ccncc1NC(=O)Cc1ccccc1

0.578

View
O=C(Cc1cccc(c1)C#N)Nc1cccnc1

0.565

View
Cc1ccncc1NC(=O)Cc1ccc(Cl)cc1

0.515

View
Cc1ccncc1NC(=O)Cc1ccc(F)cc1

0.515

View
CC(C(=O)Nc1cnccc1C)c1cccc(c1)C#N

0.500

View
CC(C(=O)Nc1cnccc1C)c1ccccc1

0.355

View
Cc1cccc(CC(=O)Nc2cccnc2)c1

0.351

View
Cc1ccc(CC(=O)Nc2cccnc2)cc1C

0.333

View
O=C(Cc1ccc(cc1)C#N)Nc1cccnc1

0.321

View
Cc1ccc(C)c(CC(=O)Nc2cccnc2)c1

0.262

View
C(NC1=C(C)C=CN=C1)(=O)CC1C=CC=C(C)C=1

0.656

View
C(NC1=C(C)C=CN=C1)(=O)CC1=CC=C(C#N)C=C1

0.631

View
C(NC1=C(C)C=CN=C1)(=O)CC1=CC=CC=C1

0.578

View
C(NC1=C(C)C=CN=C1)(=O)CC1C=CC(F)=C(C)C=1

0.551

View
C(NC1=C(C)C=CN=C1)(=O)CC1C=CC(OC)=C(C)C=1

0.535

View
C(NC1=C(C)C=CN=C1)(=O)CC1=CC=C(C)C=C1

0.530

View
C(NC1=C(C)C=CN=C1)(=O)CC1=CC=C(CC)C=C1

0.522

View
C(NC1=C(C)C=CN=C1)(=O)CC1=CC=C(Br)C=C1

0.522

View
C(NC1=C(C)C=CN=C1)(=O)CC1=CC=C(F)C=C1

0.515

View
C(NC1=C(C)C=CN=C1)(=O)CC1=CC=C(I)C=C1

0.515

View
C(NC1=C(C)C=CN=C1)(=O)CC1=CC=C(C(C)C)C=C1

0.500

View
C(NC1=C(C)C=CN=C1)(=O)CC1=CC=C(CCC)C=C1

0.500

View
C(NC1=C(C)C=CN=C1)(=O)CC1=C(C)C=CC=C1

0.493

View
C(NC1=C(C)C=CN=C1)(=O)CC1=CC=C(C)C=C1C

0.479

View
C(NC1=C(C)C=CN=C1)(=O)CC1C(C)=CC=C(C)C=1

0.472

View
C(NC1=CN=CC(C#N)=C1C)(=O)CC1C=CC=C(C)C=1

0.436

View
C(NC1=CN=CC(Cl)=C1C)(=O)CC1C=CC=C(C)C=1

0.362

View
C(NC1=CC=CN=C1)(=O)CC1C=CC=C(C)C=1

0.351

View
C(NC1=CN=CC(Cl)=C1C)(=O)CC1=CC=C(C#N)C=C1

0.346

View
C(NC1=CC=CN=C1)(=O)CC1=CC=C(C#N)C=C1

0.321

View


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