Molecule Details

Cc1ccncc1NC(=O)C(C)c1cccc(C#N)c1
3-aminopyridine-like Enamine MolPort Assayed
View on Fragalysis x2912
Molecular Properties
SMILES:
Cc1ccncc1NC(=O)C(C)c1cccc(C#N)c1
MW: 265.316
Fraction sp3: 0.19
HBA: 3
HBD: 1
Rotatable Bonds: 3
TPSA: 65.78
cLogP: 3.0039
Covalent Warhead: ✔️
Covalent Fragment: ✔️
Source
Enamine SCR: Z2186659954
Enamine REAL: Z2186659954
Enamine Extended REAL: s_22____3391102____10389944
MolPort: MolPort-047-316-421
Activity Data
IC50 (µM) - Fluorescence: 54.9421036995899
IC50 (µM) - RapidFire: 45.3119234238456
Trypsin IC50 (µM): 99.0
pIC50 (µM) - Fluorescence 4.26009471572667
Average Inhibition @ 20 µM - Fluorescence: 35.40893
Average Inhibition @ 50 µM - Fluorescence: 61.411195
Average Inhibition @ 20 µM - RapidFire: 21.0225
Average Inhibition @ 50 µM - RapidFire: 58.415
Relative Solubility @ 20 µM: 1.0
Relative Solubility @ 100 µM: 1.0
Order Status
Ordered: 2020-03-31
Synthesis Location: enamine
Shipped: 2020-04-17
Cc1ccncc1NC(=O)[C@H](C)c1cccc(Cl)c1

JAN-GHE-83b26c96-4
0.647

View
Cc1ccncc1NC(=O)[C@@H](C)c1cccc(Cl)c1

TRY-UNI-2eddb1ff-4
0.647

View
Cc1ccncc1NC(=O)C(C)c1cccc(Cl)c1

TRY-UNI-714a760b-18
0.647

View
Cc1ccncc1NC(=O)[C@@H](C)c1cccc(Cl)c1

JAN-GHE-83b26c96-5
0.647

View
Cc1ccncc1NC(=O)[C@H](C)c1cccc(Cl)c1

TRY-UNI-2eddb1ff-5
0.647

View
Cc1ccncc1NC(=O)C(C)c1cccc(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-15
0.640

View
Cc1c(N)cncc1NC(=O)C(C)c1cccc(C#N)c1

TRY-UNI-714a760b-21
0.616

View
Cc1ccncc1NC(=O)C(C)c1cccc(C2(F)CC2)c1

DAR-DIA-0cde14eb-12
0.600

View
Cc1ccncc1NC(=O)C(C)c1cccc(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-11
0.600

View
Cc1ccncc1NC(=O)C(C)c1ccccc1

AHN-SAT-202241f6-1
0.591

View
Cc1ccncc1NC(=O)C(C)c1ccccc1

TRY-UNI-714a760b-17
0.591

View
Cc1ccncc1NC(=O)C(C)c1cccc(C2(C)CC2)c1

DAR-DIA-0cde14eb-10
0.587

View
Cc1ccncc1NC(=O)C(C)c1cccc(C2(I)CC2)c1

DAR-DIA-0cde14eb-13
0.579

View
Cc1ccncc1NC(=O)Nc1cccc(C#N)c1

TRY-UNI-714a760b-24
0.534

View
Cc1ccncc1NC(=O)C(C)c1cncc(Cl)c1

TRY-UNI-2eddb1ff-3
0.528

View
Cc1ccncc1NC(=O)c1ccc(C(C)C(=O)Nc2cnccc2C)cc1Cl

MAK-UNK-f203cb68-17
0.513

View
Cc1ccncc1NC(=O)c1cc(C)c(NC(=O)C(C)c2cccc(Cl)c2)cn1

MAK-UNK-f203cb68-21
0.506

View
Cc1ccncc1NC(=O)Cc1cccc(C#N)c1

TRY-UNI-714a760b-20
0.500

View
Cc1ccncc1NC(=O)c1cc(Cl)cc(C(C)C(=O)Nc2cnccc2C)c1

MAK-UNK-f203cb68-16
0.494

View
Cc1ccncc1NC(=O)Cc1ccncc1NC(=O)C(C)c1cccc(Cl)c1

MAK-UNK-f203cb68-4
0.488

View
Cc1ccncc1NC(=O)C(C)c1cnn(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-75
0.488

View
Cc1ccncc1NC(=O)c1cncc(NC(=O)C(C)c2cccc(Cl)c2)c1C

MAK-UNK-f203cb68-22
0.483

View
Cc1ccncc1NC(=O)C(C)c1cnn(C2(C)CC2)c1

DAR-DIA-0cde14eb-70
0.481

View
CC(=O)Nc1cnccc1-c1ccc(C(C)C(=O)Nc2cnccc2C)cc1Cl

MAK-UNK-f203cb68-8
0.476

View
Cc1ccncc1NC(=O)C(C)c1cnn(C2(I)CC2)c1

DAR-DIA-0cde14eb-73
0.475

View
Cc1ccncc1NC(=O)CN(C)c1cccc(C#N)c1

GAB-REV-70cc3ca5-19
0.469

View
Cc1ccncc1NC(=O)C(C)c1cnn(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-71
0.469

View
Cc1ccncc1NC(=O)C(CO)c1cccc(Cl)c1

EDG-MED-0da5ad92-5
0.468

View
Cc1ccncc1NC(=O)C(c1cccc(Cl)c1)C(C)C

JAN-GHE-83b26c96-9
0.468

View
Cc1ccncc1NC(=O)C(CO)c1ccccc1

BEN-DND-93268d01-3
0.466

View
Cc1ccncc1NC(=O)C(C(=O)C(C)c1cccc(Cl)c1)c1cnccc1C

MAK-UNK-f203cb68-19
0.464

View
CO[C@H](C)C(=O)Nc1cnccc1C

MAT-POS-590ac91e-1
0.463

View
CO[C@@H](C)C(=O)Nc1cnccc1C

MAT-POS-590ac91e-2
0.463

View
CO[C@H](C)C(=O)Nc1cnccc1C

ERI-UCB-5b47150d-1
0.463

View
COc1cccc(C(O)C(=O)Nc2cnccc2C)c1

BAR-COM-0f94fc3d-19
0.462

View
Cc1ccncc1NC(=O)C(C)c1cnn(C2(F)CC2)c1

DAR-DIA-0cde14eb-72
0.457

View
Cc1ccncc1NC(=O)C(C)c1cc(N2CCCCC2)cc(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-30
0.457

View
Cc1ccncc1NC(=O)C(c1cccc(Cl)c1)N(C)C

JAN-GHE-83b26c96-10
0.456

View
Cc1ccncc1NC(=O)C(C)Cc1ccccc1

BEN-DND-93268d01-14
0.453

View
Cc1ccncc1NC(=O)C(F)c1ccccc1

ABI-SAT-4d06482b-1
0.452

View
CC(=O)N[C@@H](C)C(=O)Nc1cnccc1C

MAT-POS-590ac91e-13
0.443

View
Cc1ccncc1NC(=O)Nc1cncc(C#N)c1

CHR-SOS-363cfb78-2
0.442

View
CC(C(=O)Nc1cnccc1Cl)c1cccc(Cl)c1

SAM-UNK-2684b532-7
0.442

View
Cc1ccncc1NC(=O)CC#N

ASH-SAT-43770c7d-9
0.441

View
Cc1ccncc1NC(=O)c1nccc(C)c1NC(=O)C(C)c1cccc(Cl)c1

MAK-UNK-f203cb68-20
0.440

View
Cc1ccncc1NC(=O)[C@H](C)OC(F)F

MAT-POS-590ac91e-16
0.437

View
Cc1ccncc1NC(=O)c1c(Cl)cccc1C(C)C(=O)Nc1cnccc1C

MAK-UNK-f203cb68-14
0.434

View
CC(=O)Nc1cnccc1-c1cc(Cl)cc(C(C)C(=O)Nc2cnccc2C)c1

MAK-UNK-f203cb68-7
0.432

View
Cc1ccncc1NC(=O)C(C)c1cc(N2CCCCC2)cc(C2(F)CC2)c1

DAR-DIA-0cde14eb-27
0.429

View
Cc1ccncc1NC(=O)C(C#N)CC1CC1

MAT-POS-590ac91e-14
0.429

View
Cc1ccncc1NC(=O)C(C)c1cc(Cl)cc(OC2CC(=O)N2)c1

TRY-UNI-2eddb1ff-8
0.427

View
CCNc1ncc(C#N)cc1NC(=O)Nc1cnccc1C

TRY-UNI-1fd04853-2
0.427

View
Cc1ccncc1NC(=O)C(C)c1cc(N2CCCCC2)cc(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-26
0.424

View
COCC(C(=O)Nc1cnccc1C)c1ccccc1

BEN-DND-93268d01-2
0.423

View
Cc1ccncc1NC(=O)C(c1ccccc1)c1cccc(Cl)c1

SAM-UNK-2684b532-1
0.422

View
CCCC(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

JAN-GHE-83b26c96-8
0.422

View
CC(=O)Nc1ccncc1NC(=O)C(C)c1cccc(Cl)c1

JAN-GHE-83b26c96-2
0.420

View
Cc1ccncc1NC(=O)C(C)CC1CC1

MAT-POS-590ac91e-5
0.419

View
Cc1ccncc1NC(=O)C(C)c1cc(N2CCCCC2)cc(C2(C)CC2)c1

DAR-DIA-0cde14eb-25
0.418

View
Cc1ccncc1NC(=O)c1ccc(Cl)cc1C(C)C(=O)Nc1cnccc1C

MAK-UNK-f203cb68-15
0.417

View
Cc1ccncc1NC(=O)C(CNS(C)(=O)=O)c1ccccc1

DRE-WAB-eb790b7a-1
0.415

View
Cc1ccncc1NC(=O)[C@@H](CNS(C)(=O)=O)c1ccccc1

PED-UNI-5b7f1100-1
0.415

View
Cc1ccncc1NC(=O)[C@H](CNS(C)(=O)=O)c1ccccc1

DAN-RED-da448e80-1
0.415

View
CC(C(=O)Nc1cnccc1C(F)F)c1cccc(Cl)c1

SAM-UNK-2684b532-5
0.415

View
CC(C(=O)Nc1cnccc1C(F)(F)F)c1cccc(Cl)c1

SAM-UNK-2684b532-6
0.415

View
Cc1ccncc1NC(=O)[C@@H](CNS(C)(=O)=O)c1ccccc1

PED-UNI-8d53fd73-1
0.415

View
CC(=O)Nc1cnccc1-c1cc(C)c(NC(=O)C(C)c2cccc(Cl)c2)cn1

MAK-UNK-f203cb68-12
0.413

View
Cc1ccncc1NC(=O)C(C)c1cc(N2CCCCC2)cc(C2(I)CC2)c1

DAR-DIA-0cde14eb-28
0.413

View
CC(=O)Nc1cnccc1C

AAR-POS-d2a4d1df-3
0.413

View
CC(=O)Nc1cnccc1C

MAK-UNK-6435e6c2-8
0.413

View
Cc1ccncc1NC(=O)Cc1cncc(C#N)c1

TRY-UNI-2eddb1ff-1
0.412

View
Cc1ccncc1NC(=O)[C@H](CNS(C)(=O)=O)c1cccs1

DAN-RED-da448e80-17
0.410

View
Cc1nnc(C(C(=O)Nc2cnccc2C)c2cccc(Cl)c2)s1

TRY-UNI-9f475305-3
0.409

View
Cc1nnc(C(C(=O)Nc2cnccc2C)c2cccc(Cl)c2)s1

SAM-UNK-2684b532-3
0.409

View
Cc1ccncc1NC(=O)CC(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

MAK-UNK-f203cb68-3
0.407

View
CCNc1ncc(C#N)cc1C(=O)Nc1cnccc1C

SAD-SAT-cefd50cc-10
0.405

View
Cc1ccncc1NC(=O)Nc1cccc(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-9
0.405

View
CC(=O)Nc1cnccc1-c1c(Cl)cccc1C(C)C(=O)Nc1cnccc1C

MAK-UNK-f203cb68-5
0.404

View
Cc1ccncc1NC(=O)C(C)C1CCCCC1

TRY-UNI-714a760b-16
0.403

View
CC(C(=O)Nc1cnccc1O)c1ccccc1

BEN-DND-93268d01-15
0.400

View
CC(=O)Nc1cnccc1-c1ccc(Cl)cc1C(C)C(=O)Nc1cnccc1C

MAK-UNK-f203cb68-6
0.393

View
CC(=O)Nc1cnccc1-c1cncc(NC(=O)C(C)c2cccc(Cl)c2)c1C

MAK-UNK-f203cb68-13
0.391

View
Cc1ccncc1NC(=O)Cc1cc(C#N)ccc1Cc1ccccn1

THO-SYG-cc9e9a11-3
0.391

View
CC(=O)Nc1cnccc1Cc1ccncc1NC(=O)C(C)c1cccc(Cl)c1

MAK-UNK-f203cb68-2
0.391

View
Cc1ccncc1NC(=O)[C@H]1C[C@](O)(C#N)C1

MAT-POS-590ac91e-26
0.390

View
CC(C(=O)Nc1cnccc1C)=C1CC1

ERI-UCB-5b47150d-4
0.389

View
CC(C(=O)Nc1cnccc1-n1cccn1)c1cccc(Cl)c1

JAN-GHE-83b26c96-3
0.386

View
Cc1ccncc1NC(=O)Nc1cccc(Cl)c1

TRY-UNI-714a760b-12
0.385

View
Cc1ccncc1NC(=O)Nc1cccc(Cl)c1

JAG-UCB-cedd89ab-8
0.385

View
Cc1ccncc1NC(=O)CC1(C#N)CCC1

MAT-POS-590ac91e-15
0.385

View
Cc1ccncc1NC(=O)Nc1cc(C#N)cnc1CCNS(C)(=O)=O

TRY-UNI-1fd04853-3
0.385

View
CCNc1ncc(C#N)cc1CC(=O)Nc1cnccc1C

TRY-UNI-1fd04853-1
0.384

View
CCNc1ncc(C#N)cc1CC(=O)Nc1cnccc1C

PET-SGC-175e168c-1
0.384

View
Cc1ccncc1NC(=O)CC(C)C(C)C

MAT-POS-590ac91e-11
0.384

View
C=CC(=O)Nc1cnccc1C

MAK-UNK-6ca90168-27
0.382

View
Cc1ccncc1NC(=O)C(CN1CCC(O)CC1)c1ccccc1

SAM-UNK-2684b532-10
0.382

View
Cc1ccncc1NC(=O)Nc1cccc(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-6
0.381

View
Cc1ccncc1NC(=O)Nc1cccc(C2(F)CC2)c1

DAR-DIA-0cde14eb-7
0.381

View
CC(=O)Nc1cnccc1CC(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

MAK-UNK-f203cb68-1
0.380

View
Cc1ccncc1NC(=O)Cc1cc(C#N)ccc1-c1ccccn1

THO-SYG-cc9e9a11-4
0.380

View
CC1=CC(C(C)C(=O)NC2=CN=CC=C2C)=CC=C1

0.667

View
COC1=CC=CC(C(C)C(=O)NC2=CN=CC=C2C)=C1

0.652

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.647

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=CC(Br)=C1

0.647

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=CC(F)=C1

0.647

View
CC1=CC=NC=C1NC(=O)NC(C)C1=CC=CC(C#N)=C1

0.639

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=CC([N+](=O)[O-])=C1

0.625

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=CC(C(F)(F)F)=C1

0.611

View
CC1=CC=NC=C1NC(=O)C(=O)NC(C)C1=CC=CC(C#N)=C1

0.592

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=CC=C1

0.591

View
CC1=CC=NC=C1NC(=O)[C@@H](C)C1=CC=CC=C1

0.591

View
CC1=CC=NC=C1NC(=O)[C@H](C)C1=CC=CC=C1

0.591

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=CC(C(=O)C2=CC=CC=C2)=C1

0.579

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=C2C=CC=CC2=C1

0.575

View
CC1=CC=NC=C1NC(=O)C(C)OC1=CC=CC(C#N)=C1

0.573

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=C(Cl)C(Cl)=C1

0.571

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=C(F)C(F)=C1

0.563

View
CC1=CC=C(C(C)C(=O)NC2=CN=CC=C2C)C=C1

0.544

View
CC1=CC=NC=C1NC(=O)C(C)C1=CSC=C1

0.543

View
CC1=CC(F)=CC(C(C)C(=O)NC2=CN=CC=C2C)=C1

0.542

View
COC1=CC=C(C(C)C(=O)NC2=CN=CC=C2C)C=C1OC

0.541

View
CC1=CC=NC=C1NC(=O)C(C)NS(=O)(=O)C1=CC=CC(C#N)=C1

0.531

View
CC1=CC=NC=C1NC(=O)NC(C)C1=CC=C(C2=CC=CC(C#N)=C2)C=C1

0.530

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=C(Br)C=C1

0.529

View
CC1=CC=NC=C1NC(=O)C(C)C1=CN(C)N=C1

0.521

View
CC1=CC=NC=C1NC(=O)C1=CC=CC(C#N)=C1

0.521

View
CC1=CC=NC=C1NC(=O)C(C)C#N

0.515

View
CCC1=CC=C(C(C)C(=O)NC2=CN=CC=C2C)C=C1

0.514

View
COC1=CC=C(C(C)C(=O)NC2=CN=CC=C2C)C=C1

0.514

View
CC1=CC=NC=C1NC(=O)C(C)C1=C(F)C=CC=C1F

0.507

View
CC1=CC=NC=C1NC(=O)NNC(=O)C1=CC=CC(C#N)=C1

0.506

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=C2OCCOC2=C1

0.506

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=C2OCOC2=C1

0.506

View
CC1=CC=NC=C1NC(=O)NC1(C2=CC=CC(C#N)=C2)CC1

0.506

View
CC1=CC=NC=C1NC(=O)NNC1=CC=CC(C#N)=C1

0.500

View
COC1=CC=C2C=C([C@H](C)C(=O)NC3=CN=CC=C3C)C=CC2=C1

0.500

View
CC1=CC=NC=C1NC(=O)NCC1=CC=CC(C#N)=C1

0.500

View
CC1=CC=NC=C1NC(=O)C(C)C1=C(Cl)C=CC=C1Cl

0.500

View
CC1=CC=NC=C1NC(=O)N(C)CC1=CC=CC(C#N)=C1

0.500

View
CC1=CN=CC=C1NC(=O)NC(C)C1=CC=CC(C#N)=C1

0.494

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=CC=C1C

0.493

View
CC1=CC=NC=C1NC(=O)C(=O)NC(C)C1=CC=C(C2=CC=CC(C#N)=C2)C=C1

0.488

View
CC1=CC=NC=C1NC(=O)COC1=CC=CC(C#N)=C1

0.487

View
CC1=CC=NC=C1NC(=O)NC(C)C1=CC=C(C#N)C=C1

0.487

View
CC1=CC=NC=C1NC(=O)C(C)C(C)C(=O)NC1=CN=CC=C1C

0.484

View
CC1=CC=NC=C1NC(=O)C(C)OC1=CC=C(C#N)C=C1

0.481

View
CC1=CC=NC=C1NC(=O)C(C)SC1=CC=C(C#N)C=C1

0.481

View
CC1=CC(C(C)C(=O)NC2=CN=CC=C2O)=CC=C1

0.480

View
CC1=CC=NC=C1NC(=O)NCCC1=CC=CC(C#N)=C1

0.476

View
COC1=CC=CC(C(C)C(=O)NC2=CC(C#N)=CC=C2C)=C1

0.475

View
CC1=CC=NC=C1C(C)NC(=O)C(=O)NC(C)C1=CC=CC(C#N)=C1

0.475

View
CC1=CC=NC=C1NC(=O)C1(C2=CC=CC(C#N)=C2)CC1

0.475

View
CC1=CC(C(C)C(=O)NC2=CC=NC=C2C#N)=CC=C1

0.474

View
CC1=CC(C(C)C(=O)NC2=CC=NC=C2C)=CC=C1

0.473

View
CC1=CC=NC=C1NC(=O)C(=O)NNC1=CC=CC(C#N)=C1

0.469

View
CC1=CC=NC=C1NC(=O)C(=O)NCC1=CC=CC(C#N)=C1

0.469

View
CC1=CC=NC=C1C(=O)NC(C)C1=CC=CC(C#N)=C1

0.468

View
CC1=CC=NC=C1C(C)NC(=O)NC(C)C1=CC=CC(C#N)=C1

0.468

View
CC1=CC(C(C)C(=O)NC2=CC(C#N)=CC=C2C)=CC=C1

0.468

View
CC1=CC=NC=C1NC(=O)C(=O)NNC(=O)C1=CC=CC(C#N)=C1

0.458

View
COC1=CC=CC(C(C)C(=O)NC2=CC=NC=C2C#N)=C1

0.457

View
CC1=CC=NC=C1NC(=O)C(C)NS(=O)(=O)C1=CC=C(C#N)C=C1

0.457

View
CC1=CC=C(C#N)C=C1NC(=O)C(C)C1=CC=CC(Br)=C1

0.456

View
CC1=CC=C(C#N)C=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.456

View
CC1=CC=C(C#N)C=C1NC(=O)C(C)C1=CC=CC(F)=C1

0.456

View
CC1=CN=CC=C1C(=O)NC(C)C1=CC=CC(C#N)=C1

0.456

View
CC1=CN=CC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.455

View
CC1=CN=CC=C1NC(=O)C(C)C1=CC=CC(Br)=C1

0.455

View
CC1=CN=CC=C1NC(=O)C(C)C1=CC=CC(F)=C1

0.455

View
CC(C(=O)NC1=CC=NC=C1C#N)C1=CC=CC(Cl)=C1

0.450

View
CC(C(=O)NC1=CC=NC=C1C#N)C1=CC=CC(F)=C1

0.450

View
CC(C(=O)NC1=CC=NC=C1C#N)C1=CC=CC(Br)=C1

0.450

View
CC1=CC=NC=C1C(=O)OC(C)C1=CC=CC(C#N)=C1

0.450

View
CC(=O)NC1=CC=NC=C1NC(=O)C(C)C1=CC=CC(C)=C1

0.443

View
CC1=CC(C(C)C(=O)NC2=CC=CC(C#N)=C2)=CC=C1

0.442

View
CC1=CC=NC=C1NC(=O)C1=CC=C(C#N)C=C1

0.438

View
CC1=CC=NC=C1NC(=O)C(=O)NC(C)C1=CC=C(C#N)C=C1

0.438

View
CC1=CC(C(C)C(=O)NC2=CC=C(C#N)C=C2Cl)=CC=C1

0.436

View
CC1=CC=NC=C1NC(=O)C1=CC(C#N)=CC=C1Cl

0.436

View
CC1=CC=C(C#N)C=C1NC(=O)C(C)C1=CC=CC([N+](=O)[O-])=C1

0.434

View
CC1=CC(C(C)C(=O)NC2=CC=C(C#N)C=N2)=CC=C1

0.430

View
CC1=CC=C(C#N)C=C1NC(=O)C(C)C1=CC=CC(C(=O)C2=CC=CC=C2)=C1

0.425

View
CC(C(=O)NC1=CC=NC=C1C#N)C1=CC=CC(C(=O)C2=CC=CC=C2)=C1

0.425

View
CNC1=CC=C(C#N)C=C1NC(=O)C(C)C1=CC=CC(C)=C1

0.425

View
CC(C(=O)NC1=CC=C(C#N)C=C1Cl)C1=CC=CC(Cl)=C1

0.423

View
CC1=CN=CC=C1NC(=O)C(C)OC1=CC=CC(C#N)=C1

0.422

View
CC1=CC=C(C#N)C=C1NC(=O)C(C)C1=CC=CC=C1

0.416

View
CC1=CC=C(C#N)C=C1NC(=O)[C@H](C)C1=CC=CC=C1

0.416

View
CC1=CC=C(C#N)C=C1NC(=O)[C@@H](C)C1=CC=CC=C1

0.416

View
CC(C(=O)NC1=CC=C(C#N)C=C1Cl)C1=CC=CC(Br)=C1

0.412

View
CC1=CC=C(C#N)C=C1NC(=O)C(C1=CC=CN=C1)C(C)C

0.410

View
CC1=CC=C(C#N)C=C1NC(=O)C(C)C1=CC=C2C=CC=CC2=C1

0.405

View
CNC1=CC=C(C#N)C=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.402

View
CNC1=CC=C(C#N)C=C1NC(=O)C(C)C1=CC=CC(Br)=C1

0.402

View
CC1=CC=C(C#N)C=C1NC(=O)C(C)C1=CN(C)N=C1

0.402

View
CNC1=CC=C(C#N)C=C1NC(=O)C(C)C1=CC=CC(F)=C1

0.402

View
CC(C(=O)NC1=CC=NC=C1C#N)C1=CC=CC=C1

0.397

View
C[C@H](C(=O)NC1=CC=NC=C1C#N)C1=CC=CC=C1

0.397

View
C[C@@H](C(=O)NC1=CC=NC=C1C#N)C1=CC=CC=C1

0.397

View
CC1=CC=C(C#N)C=C1NC(=O)C(O)C1=CC=CN=C1

0.386

View
CC(C(=O)Nc1cnccc1C)c1cccc(c1)C#N

1.000

View
CC(C(=O)Nc1cnccc1C)c1ccccc1

0.591

View
Cc1ccncc1NC(=O)Cc1cccc(c1)C#N

0.500

View
Cc1ccncc1NC(=O)Cc1ccccc1

0.355

View
O=C(Cc1cccc(c1)C#N)Nc1cccnc1

0.294

View
CC(C(=O)Nc1cccnc1)c1ccccc1

0.291

View
C(NC1=C(C)C=CN=C1)(=O)C(C)C1=CC=CC=C1

0.882

View
C(NC1=C(C)C=CN=C1)(=O)C(C1=CC=C(C)C=C1)C

0.878

View
C(NC1=C(C)C=CN=C1)(=O)C(C)C1=CC=C(F)C=C1

0.832

View
C(NC1=C(C)C=CN=C1)(=O)CC1C=CC=C(C)C=1

0.832

View
C(NC1=C(C)C=CN=C1)(=O)C(C)C1=CC=C(Br)C=C1

0.828

View


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