Molecule Details

Cc1ccncc1NC(=O)c1ccc(Cl)cc1C(C)C(=O)Nc1cnccc1C
3-aminopyridine-like
Molecular Properties
SMILES:
Cc1ccncc1NC(=O)c1ccc(Cl)cc1C(C)C(=O)Nc1cnccc1C
MW: 408.14
Fraction sp3: 0.18
HBA: 4
HBD: 2
Rotatable Bonds: 5
TPSA: 83.98
cLogP: 4.74
Covalent Warhead:
Covalent Fragment:
CC(=O)Nc1cnccc1C

MAK-UNK-6435e6c2-8

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Cc1ccncc1NC(=O)c1ccc(C(C)C(=O)Nc2cnccc2C)cc1Cl

MAK-UNK-f203cb68-17
0.571

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CC(=O)Nc1cnccc1-c1ccc(Cl)cc1C(C)C(=O)Nc1cnccc1C

MAK-UNK-f203cb68-6
0.568

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Cc1ccncc1NC(=O)c1c(Cl)cccc1C(C)C(=O)Nc1cnccc1C

MAK-UNK-f203cb68-14
0.544

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Cc1ccncc1NC(=O)[C@@H](C)c1cccc(Cl)c1

TRY-UNI-2eddb1ff-4
0.513

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Cc1ccncc1NC(=O)C(C)c1cccc(Cl)c1

TRY-UNI-714a760b-18
0.513

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Cc1ccncc1NC(=O)[C@H](C)c1cccc(Cl)c1

JAN-GHE-83b26c96-4
0.513

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Cc1ccncc1NC(=O)[C@@H](C)c1cccc(Cl)c1

JAN-GHE-83b26c96-5
0.513

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Cc1ccncc1NC(=O)[C@H](C)c1cccc(Cl)c1

TRY-UNI-2eddb1ff-5
0.513

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Cc1ccncc1NC(=O)c1cc(Cl)cc(C(C)C(=O)Nc2cnccc2C)c1

MAK-UNK-f203cb68-16
0.512

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Cc1ccncc1NC(=O)C(C)c1cncc(Cl)c1

TRY-UNI-2eddb1ff-3
0.507

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Cc1ccncc1NC(=O)c1cncc(NC(=O)C(C)c2cccc(Cl)c2)c1C

MAK-UNK-f203cb68-22
0.483

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Cc1ccncc1NC(=O)C(C)c1ccccc1

TRY-UNI-714a760b-17
0.459

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Cc1ccncc1NC(=O)C(C)c1ccccc1

AHN-SAT-202241f6-1
0.459

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Cc1ccncc1NC(=O)C(c1cccc(Cl)c1)N(C)C

JAN-GHE-83b26c96-10
0.457

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Cc1ccncc1NC(=O)c1cc(C)c(NC(=O)C(C)c2cccc(Cl)c2)cn1

MAK-UNK-f203cb68-21
0.456

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Cc1ccncc1NC(=O)C(c1cccc(Cl)c1)C(C)C

JAN-GHE-83b26c96-9
0.450

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Cc1ccncc1NC(=O)C(C(=O)C(C)c1cccc(Cl)c1)c1cnccc1C

MAK-UNK-f203cb68-19
0.448

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Cc1ccncc1NC(=O)C(C)c1cc(Cl)cc(OC2CC(=O)N2)c1

TRY-UNI-2eddb1ff-8
0.444

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CO[C@@H](C)C(=O)Nc1cnccc1C

MAT-POS-590ac91e-2
0.443

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CO[C@H](C)C(=O)Nc1cnccc1C

MAT-POS-590ac91e-1
0.443

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CO[C@H](C)C(=O)Nc1cnccc1C

ERI-UCB-5b47150d-1
0.443

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Cc1ccncc1NC(=O)Nc1cccc(Cl)c1

TRY-UNI-714a760b-12
0.442

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Cc1ccncc1NC(=O)Nc1cccc(Cl)c1

JAG-UCB-cedd89ab-8
0.442

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Cc1ccncc1NC(=O)[C@@H](C)OC(F)F

MAT-POS-5d20d11c-1
0.438

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Cc1ccncc1NC(=O)[C@H](C)OC(F)F

MAT-POS-590ac91e-16
0.438

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CC(=O)Nc1cnccc1-c1c(Cl)cccc1C(C)C(=O)Nc1cnccc1C

MAK-UNK-f203cb68-5
0.438

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COC(=O)C(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

MAT-POS-1e5f28a7-1
0.434

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Cc1ccncc1NC(=O)C(CO)c1cccc(Cl)c1

EDG-MED-0da5ad92-5
0.432

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Cc1nnc(C(C(=O)Nc2cnccc2C)c2cccc(Cl)c2)s1

SAM-UNK-2684b532-3
0.427

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Cc1nnc(C(C(=O)Nc2cnccc2C)c2cccc(Cl)c2)s1

TRY-UNI-9f475305-3
0.427

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CC(=O)N[C@@H](C)C(=O)Nc1cnccc1C

MAT-POS-590ac91e-13
0.425

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CCCC(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

JAN-GHE-83b26c96-8
0.424

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Cc1ccncc1NC(=O)C(c1ccccc1)c1cccc(Cl)c1

SAM-UNK-2684b532-1
0.424

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Cc1ccncc1NC(=O)C(C)c1cnn(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-71
0.419

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CC(=O)Nc1cnccc1-c1cc(Cl)cc(C(C)C(=O)Nc2cnccc2C)c1

MAK-UNK-f203cb68-7
0.418

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Cc1ccncc1NC(=O)C(C)c1cccc(C#N)c1

TRY-UNI-714a760b-22
0.417

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Cc1ccncc1NC(=O)C(C)c1cccc(C2(F)CC2)c1

DAR-DIA-0cde14eb-12
0.414

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Cc1ccncc1NC(=O)C(C)c1cccc(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-11
0.414

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Cc1ccncc1NC(=O)C(C)c1cnn(C2(C)CC2)c1

DAR-DIA-0cde14eb-70
0.412

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CC(=O)Nc1cnccc1-c1ccc(C(C)C(=O)Nc2cnccc2C)cc1Cl

MAK-UNK-f203cb68-8
0.411

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Cc1ccncc1NC(=O)c1nccc(C)c1NC(=O)C(C)c1cccc(Cl)c1

MAK-UNK-f203cb68-20
0.411

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Cc1ccncc1NC(=O)C(C)c1cnn(C2(F)CC2)c1

DAR-DIA-0cde14eb-72
0.407

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Cc1ccncc1NC(=O)C(C)c1cnn(C2(I)CC2)c1

DAR-DIA-0cde14eb-73
0.407

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Cc1ccncc1NC(=O)C(C)CC1CC1

MAT-POS-590ac91e-5
0.403

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Cc1ccncc1NC(=O)C(C)c1cccc(C2(C)CC2)c1

DAR-DIA-0cde14eb-10
0.402

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Cc1ccncc1NC(=O)CCl

MAK-UNK-6ca90168-26
0.400

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Cc1ccncc1NC(=O)c1ccncc1NC(=O)Nc1ccccc1

MAK-UNK-129dcd6f-15
0.400

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Cc1ccncc1NC(=O)C(=O)c1cccc(Cl)c1

MAK-UNK-6ca90168-24
0.400

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Cc1ccncc1NC(=O)C(C)c1cccc(C2(I)CC2)c1

DAR-DIA-0cde14eb-13
0.398

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Cc1ccncc1NC(=O)C(F)c1ccccc1

ABI-SAT-4d06482b-1
0.397

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CC(=O)Nc1cnccc1C

MAK-UNK-6435e6c2-8
0.394

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CC(=O)Nc1cnccc1C

AAR-POS-d2a4d1df-3
0.394

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Cc1ccncc1NC(=O)Cc1ccncc1NC(=O)C(C)c1cccc(Cl)c1

MAK-UNK-f203cb68-4
0.394

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Cc1ccncc1NC(=O)CC(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

MAK-UNK-f203cb68-3
0.393

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Cc1ccncc1NC(=O)[C@H](CNS(C)(=O)=O)c1ccc(Cl)cc1

DAN-RED-da448e80-9
0.391

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Cc1ccncc1NC(=O)C(C)c1cnn(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-75
0.389

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Cc1ccncc1NC(=O)C(C)C1CCCCC1

TRY-UNI-714a760b-16
0.388

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Cc1ccncc1NC(=O)CC(C)C(C)C

MAT-POS-590ac91e-11
0.387

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C(C)C(N)=O)c1

WIL-MOD-03b86a88-3
0.386

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Cc1ccncc1NC(=O)C(C)c1cccc(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-15
0.385

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Cc1ccncc1NC(=O)Cc1cccc(Cl)c1

TRY-UNI-714a760b-6
0.383

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Cc1ccncc1NC(=O)C(C)Cc1ccccc1

BEN-DND-93268d01-14
0.383

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Cc1ccncc1NC(=O)c1ccccc1NC(=O)Nc1cccnc1

MAK-UNK-129dcd6f-4
0.382

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CC(=O)N1CCN(C(C(=O)Nc2cnccc2C)c2cccc(Cl)c2)CC1

VLA-UCB-05e51b3f-2
0.380

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Cc1ccncc1NC(=O)C1(c2cccc(Cl)c2)CC(=O)C1

BAR-COM-0f94fc3d-25
0.379

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COc1ccc(Br)cc1C(N)C(=O)Nc1cnccc1C

BAR-COM-0f94fc3d-58
0.379

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Cc1ccncc1NC(=O)C(C(=O)c1cc(=O)[nH]c2ccccc12)c1cccc(Cl)c1

ALP-POS-ddb41b15-1
0.379

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Cc1ccncc1NC(=O)N(c1cccc(Cl)c1)c1cccc(Cl)c1

EDG-MED-0da5ad92-19
0.378

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Cc1ccncc1NC(=O)N(C)c1cccc(Cl)c1

EDG-MED-0da5ad92-3
0.378

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Cc1nnc(C(C(=O)Nc2cnccc2C)N2CCCC(F)C2)s1

TRY-UNI-9f475305-5
0.375

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Cc1nnc(C(C(=O)Nc2cnccc2C)N2CCCC(F)C2)s1

PET-SGC-01d224dd-1
0.375

View
Cc1ccncc1NC(=O)Cn1ccc2ccc(Cl)cc21

BAR-COM-0f94fc3d-41
0.375

View
Cc1ccncc1NC(=O)C(CO)c1ccccc1

BEN-DND-93268d01-3
0.375

View
CCNc1ncc(C#N)cc1C(=O)Nc1cnccc1C

SAD-SAT-cefd50cc-10
0.375

View
Cc1ccncc1NC(=O)C(C)(C)c1cccc(Cl)c1

EDG-MED-0da5ad92-10
0.373

View
Cc1ccncc1NC(=O)C(C)(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

MAK-UNK-f203cb68-18
0.373

View
Cc1ccncc1NC(=O)C(C)(C)c1cccc(Cl)c1

JAN-GHE-83b26c96-22
0.373

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Cc1ccncc1NC(=O)C(C)c1cc(N2CCCCC2)cc(C2(F)CC2)c1

DAR-DIA-0cde14eb-27
0.371

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Cc1ccncc1NC(=O)[C@@H]1CCc2ccc(Cl)cc21

ADA-UCB-6c2cb422-2
0.371

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Cc1ccncc1NC(=O)Cc1cncc(Cl)c1

TRY-UNI-2eddb1ff-2
0.370

View
Cc1ccncc1NC(=O)Cc1cncc(Cl)c1

EDG-MED-0da5ad92-8
0.370

View
CC(=O)Nc1cnccc1CC(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

MAK-UNK-f203cb68-1
0.368

View
Cc1ccncc1NC(=O)C(C)c1cc(N2CCCCC2)cc(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-26
0.367

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C=CC(=O)Nc1cnccc1C

MAK-UNK-6ca90168-27
0.366

View
Cc1ccncc1NC(=O)CC#N

ASH-SAT-43770c7d-9
0.365

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COc1cc(Cl)cc(OC(=O)Nc2cnccc2C)c1

MAT-POS-6c3d76b3-1
0.365

View
Cc1ccncc1NC(=O)c1csc(CCN)n1

MAR-TRE-67513f76-68
0.365

View
Cc1ccncc1NC(=O)C(F)(F)c1cccc(Cl)c1

JAN-GHE-83b26c96-23
0.365

View
COc1cc(Cl)cc(OC(=O)Nc2cnccc2C)c1

MAT-POS-0d6fb2dd-1
0.365

View
Cc1ccncc1NC(=O)CCc1cccc(Cl)c1

ALP-POS-f13221e1-4
0.365

View
Cc1ccncc1NC(=O)Nc1ccccc1

TRY-UNI-714a760b-4
0.364

View
COc1ccccc1OC[C@H](C(=O)Nc1cnccc1C)c1cccc(Cl)c1

ADA-UCB-6c2cb422-9
0.364

View
Cc1ccncc1NC(=O)Nc1ccccc1

ALE-HEI-f28a35b5-1
0.364

View
Cc1ccncc1NC(=O)C(C#N)CC1CC1

MAT-POS-590ac91e-14
0.361

View
Cc1ccncc1NC(=O)C(C)c1cc(N2CCCCC2)cc(C2(C)CC2)c1

DAR-DIA-0cde14eb-25
0.361

View
Cc1ccncc1NC(=O)C1(c2cccc(Cl)c2)CC1

EDG-MED-0da5ad92-11
0.360

View
Cc1ccncc1NC(=O)C1(c2cccc(Cl)c2)CC1

JAN-GHE-83b26c96-20
0.360

View
COc1cccc(C(O)C(=O)Nc2cnccc2C)c1

BAR-COM-0f94fc3d-19
0.360

View
Cc1ccncc1NC(=O)c1cccc(NC(=O)Nc2cccnc2)c1

MAK-UNK-129dcd6f-9
0.360

View
Cc1nnc(C(C(=O)Nc2cnccc2C)N2CCC=C(F)C2)s1

TRY-UNI-9f475305-4
0.358

View
Cc1ccncc1NC(=O)c1ccc(Cl)cc1Cl

0.717

View
Cc1ccncc1NC(=O)c1ccc(Cl)cc1C

0.717

View
Cc1ccncc1NC(=O)c1cc(Cl)ccc1C(C)C

0.714

View
CNc1cc(Cl)ccc1C(=O)Nc1cnccc1C

0.688

View
Cc1ccncc1NC(=O)c1cc(Cl)ccc1C

0.681

View
Cc1ccncc1NC(=O)c1ccc(Cl)cc1N

0.673

View
Cc1ccncc1NC(=O)c1ccc(Cl)cc1O

0.673

View
Cc1ccncc1NC(=O)c1ccc(Cl)cc1F

0.673

View
Cc1ccncc1NC(=O)c1cc(Cl)ccc1F

0.673

View
Cc1ccncc1NC(=O)c1ccc(Cl)cc1Br

0.673

View
Cc1ccncc1NC(=O)c1cc(Cl)ccc1Cl

0.667

View
COc1cc(Cl)ccc1C(=O)Nc1cnccc1C

0.660

View
Cc1ccncc1NC(=O)C(C)c1cccc(Cl)c1

0.660

View
Cc1ccncc1NC(=O)c1cc(Cl)ccc1OC(C)C

0.642

View
Cc1ccncc1NC(=O)c1ccc(F)cc1Cl

0.640

View
Cc1ccncc1NC(=O)c1cc(Cl)ccc1N

0.640

View
Cc1ccncc1NC(=O)c1cc(Cl)ccc1Br

0.640

View
Cc1ccncc1NC(=O)c1cc(Cl)ccc1I

0.640

View
Cc1ccncc1NC(=O)c1ccc(Cl)cc1[N+](=O)[O-]

0.635

View
Cc1ccncc1NC(=O)c1ccc(Cl)cc1C(F)(F)F

0.635

View
CCNc1ccc(Cl)cc1C(=O)Nc1cnccc1C

0.635

View
CCSc1cc(Cl)ccc1C(=O)Nc1cnccc1C

0.635

View
Cc1ccc(C(=O)Nc2cnccc2C)c(Cl)c1

0.633

View
Cc1cc(Cl)c(C(=O)Nc2cnccc2C)cc1C

0.625

View
COc1ccc(Cl)cc1C(=O)Nc1cnccc1C

0.615

View
Cc1ccc(Cl)cc1NC(=O)c1cnccc1C

0.612

View
Cc1cc(Cl)ccc1NC(=O)c1cnccc1C

0.612

View
Cc1ccncc1NC(=O)C(C)c1ccccc1C

0.612

View
Cc1ccncc1NC(=O)c1ccc(Cl)cc1NC(=O)c1ccoc1C

0.611

View
CCOc1cc(Cl)ccc1C(=O)Nc1cnccc1C

0.611

View
Cc1ccncc1NC(=O)c1ccc(Br)cc1Cl

0.608

View
Cc1ccncc1NC(=O)c1ccc(I)cc1Cl

0.608

View
COc1ccc(C(=O)Nc2cnccc2C)c(Cl)c1

0.608

View
Cc1ccncc1NC(=O)c1cc(Cl)cc(Cl)c1

0.604

View
Cc1ccncc1NC(=O)c1cc(Cl)ccc1[N+](=O)[O-]

0.604

View
Cc1ccncc1NC(=O)c1ccc(C(F)(F)F)cc1Cl

0.604

View
Cc1ccncc1C(=O)Nc1ccc(Cl)cc1Cl

0.600

View
Cc1ccncc1NC(=O)C(C)C(C)C(=O)Nc1cnccc1C

0.600

View
Cc1ccncc1NC(=O)c1cc(Cl)ccc1OC(F)F

0.600

View
Cc1ccncc1C(=O)Nc1cc(Cl)ccc1NC(C)C

0.596

View
Cc1ccncc1NC(=O)C(C)c1ccc(Cl)c(Cl)c1

0.596

View
Cc1ccncc1C(=O)Nc1cc(Cl)ccc1C(=O)NC(C)C

0.593

View
Cc1ccncc1NC(=O)C(C)Oc1ccc(Cl)cc1C

0.593

View
Cc1ccncc1NC(=O)C(C)Sc1cc(Cl)ccc1Cl

0.593

View
Cc1ccncc1NC(=O)C(C)Cc1ccc(Cl)cc1Cl

0.593

View
CCSc1ccc(Cl)cc1C(=O)Nc1cnccc1C

0.593

View
Cc1ccncc1NC(=O)N[C@H](C)c1cc(Cl)ccc1Cl

0.593

View
Cc1ccncc1NC(=O)N[C@@H](C)c1cc(Cl)ccc1Cl

0.593

View
Cc1ccncc1NC(=O)c1ccc(C)c(Cl)c1Cl

0.592

View
Cc1ccncc1NC(=O)c1cc(F)c(F)cc1Cl

0.588

View
Cc1ccncc1NC(=O)C(C)c1c(Cl)cccc1Cl

0.588

View
Cc1cc(Cl)ccc1C(=O)Nc1cnccc1O

0.588

View
Cc1ccncc1NC(=O)C(C)NC(=O)c1ccc(Cl)cc1

0.585

View
CC(=O)Nc1ccc(C(=O)Nc2cnccc2C)c(Cl)c1

0.585

View
Cc1ccncc1NC(=O)C(C)c1ccc(F)cc1F

0.585

View
Cc1cnccc1NC(=O)c1cc(Cl)ccc1C(C)C

0.585

View
Cc1ccncc1NC(=O)c1ccc(Cl)cc1

0.583

View
Cc1ccncc1NC(=O)c1ccncc1Cl

0.583

View
Cc1ccncc1NC(=O)C(C)Oc1ccc(Cl)cc1Cl

0.582

View
Cc1ccncc1NC(=O)c1cc2ccc(Cl)cc2nc1C

0.582

View
Cc1ccncc1NC(=O)c1cc(NC(=O)C(C)C)ccc1Cl

0.582

View
Cc1ccncc1NC(=O)C(O)c1ccc(Cl)cc1F

0.582

View
Cc1ccncc1NC(=O)C(=O)N[C@@H](C)c1cc(Cl)ccc1Cl

0.582

View
Cc1ccncc1NC(=O)C(=O)N[C@H](C)c1cc(Cl)ccc1Cl

0.582

View
Cc1cc(Cl)ccc1NC(=O)c1ccncc1C

0.580

View
Cc1cc(C(=O)Nc2cnccc2C)c(C)cc1Cl

0.580

View
Cc1ccncc1NC(=O)c1ccccc1C(C)C

0.580

View
Cc1ccncc1NC(=O)c1ccc(C)c(C)c1Cl

0.580

View
Cc1cnccc1NC(=O)c1ccc(Cl)cc1C

0.580

View
Cc1ccc(Cl)cc1NC(=O)c1ccncc1C

0.580

View
Cc1cnccc1NC(=O)c1ccc(Cl)cc1Cl

0.580

View
Cc1ccncc1NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1ccccc1

0.579

View
Cc1ccncc1NC(=O)c1cc(Cl)ccc1NS(=O)(=O)c1ccccc1

0.579

View
Cc1ccncc1C(=O)Nc1ccc(Cl)cc1F

0.577

View
Cc1ccncc1C(=O)Nc1ccc(Cl)cc1I

0.577

View
Cc1ccncc1C(=O)Nc1ccc(Cl)cc1Br

0.577

View
Cc1ccncc1C(=O)Nc1cc(Cl)ccc1Br

0.577

View
Cc1ccncc1C(=O)Nc1ccc(Cl)cc1O

0.577

View
Cc1ccncc1NC(=O)C(c1ccc(Cl)cc1)C(C)C

0.577

View
Cc1ccncc1NC(=O)c1cc(F)c(Cl)cc1Cl

0.577

View
Cc1ccncc1NC(=O)C(C)c1ccccc1F

0.577

View
Cc1ccncc1NC(=O)c1cc(Cl)c(F)cc1Cl

0.577

View
Cc1ccncc1NC(=O)c1cc(I)c(Cl)cc1Cl

0.577

View
Cc1ccncc1NC(=O)C(c1cccc(Cl)c1)C(C)C

0.574

View
Cc1ccncc1NC(=O)C(=O)NNC(=O)c1ccc(Cl)cc1Cl

0.574

View
Cc1ccc(C(=O)Nc2cnccc2C)c(C)c1

0.571

View
CCCOc1ccc(Cl)cc1C(=O)Nc1cnccc1C

0.571

View
Cc1ccncc1NC(=O)N[C@H](C)c1cc(Cl)ccc1F

0.571

View
Cc1ccncc1NC(=O)c1ccsc1NC(=O)c1ccc(Cl)cc1O

0.569

View
Cc1ccncc1C(=O)Nc1cc(Cl)ccc1Cl

0.569

View
Cc1cnccc1C(=O)Nc1ccc(Cl)cc1Cl

0.569

View
Cc1cc(Cl)ccc1NC(=O)c1ccncc1Cl

0.569

View
Cc1ccncc1NC(=O)c1cccc(Cl)c1

0.569

View
Cc1ccncc1NC(=O)c1ccc(Cl)nc1C

0.569

View
Cc1cc(Cl)cc(C(=O)Nc2cnccc2C)c1

0.569

View
Cc1ccc(Cl)cc1NC(=O)c1ccncc1Cl

0.569

View
CNC(=O)c1ccc(Cl)cc1NC(=O)c1cnccc1C

0.566

View
CC(=O)Nc1ccc(Cl)cc1NC(=O)c1cnccc1C

0.566

View
CC(=O)Nc1cc(Cl)ccc1NC(=O)c1cnccc1C

0.566

View
COc1cc(Cl)ccc1NC(=O)c1cnccc1C

0.566

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