Molecule Details

Cc1ccncc1NC(=O)C(C)c1cccc(Cl)c1
3-aminopyridine-like Enamine MolPort Assayed
View on Fragalysis x2649
Molecular Properties
SMILES:
Cc1ccncc1NC(=O)C(C)c1cccc(Cl)c1
MW: 274.751
Fraction sp3: 0.2
HBA: 2
HBD: 1
Rotatable Bonds: 3
TPSA: 41.99
cLogP: 3.78562
Covalent Warhead:
Covalent Fragment: ✔️
Source
Enamine SCR: Z1264525706
Enamine REAL: Z1264525706
Enamine Extended REAL: s_22____3391102____5826328
MolPort: MolPort-047-316-321
Activity Data
IC50 (µM) - Fluorescence: 26.1796376915625
IC50 (µM) - RapidFire: 12.9676931084341
Trypsin IC50 (µM): 99.0
pIC50 (µM) - Fluorescence 4.58203636808488
Average Inhibition @ 20 µM - Fluorescence: 58.02024
Average Inhibition @ 50 µM - Fluorescence: 78.712695
Average Inhibition @ 20 µM - RapidFire: 20.37830295
Relative Solubility @ 20 µM: 1.0
Relative Solubility @ 100 µM: 1.0
Order Status
Ordered: 2020-03-31
Synthesis Location: enamine
Shipped: 2020-04-09
Cc1ccncc1NC(=O)[C@@H](C)c1cccc(Cl)c1

JAN-GHE-83b26c96-5
1.000

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Cc1ccncc1NC(=O)[C@H](C)c1cccc(Cl)c1

TRY-UNI-2eddb1ff-5
1.000

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Cc1ccncc1NC(=O)[C@@H](C)c1cccc(Cl)c1

TRY-UNI-2eddb1ff-4
1.000

View
Cc1ccncc1NC(=O)C(C)c1cccc(Cl)c1

TRY-UNI-714a760b-18
1.000

View
Cc1ccncc1NC(=O)c1cc(C)c(NC(=O)C(C)c2cccc(Cl)c2)cn1

MAK-UNK-f203cb68-21
0.746

View
Cc1ccncc1NC(=O)Cc1ccncc1NC(=O)C(C)c1cccc(Cl)c1

MAK-UNK-f203cb68-4
0.722

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Cc1ccncc1NC(=O)c1cncc(NC(=O)C(C)c2cccc(Cl)c2)c1C

MAK-UNK-f203cb68-22
0.712

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CC(C(=O)Nc1cnccc1Cl)c1cccc(Cl)c1

SAM-UNK-2684b532-7
0.698

View
Cc1ccncc1NC(=O)C(c1cccc(Cl)c1)C(C)C

JAN-GHE-83b26c96-9
0.677

View
Cc1ccncc1NC(=O)C(C(=O)C(C)c1cccc(Cl)c1)c1cnccc1C

MAK-UNK-f203cb68-19
0.676

View
Cc1ccncc1NC(=O)C(c1cccc(Cl)c1)N(C)C

JAN-GHE-83b26c96-10
0.657

View
CC(=O)Nc1ccncc1NC(=O)C(C)c1cccc(Cl)c1

JAN-GHE-83b26c96-2
0.657

View
Cc1ccncc1NC(=O)C(C)c1cncc(Cl)c1

TRY-UNI-2eddb1ff-3
0.656

View
Cc1ccncc1NC(=O)C(CO)c1cccc(Cl)c1

EDG-MED-0da5ad92-5
0.652

View
Cc1ccncc1NC(=O)c1nccc(C)c1NC(=O)C(C)c1cccc(Cl)c1

MAK-UNK-f203cb68-20
0.649

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CC(C(=O)Nc1cnccc1C(F)(F)F)c1cccc(Cl)c1

SAM-UNK-2684b532-6
0.647

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Cc1ccncc1NC(=O)C(C)c1cccc(C#N)c1

TRY-UNI-714a760b-22
0.647

View
CC(C(=O)Nc1cnccc1C(F)F)c1cccc(Cl)c1

SAM-UNK-2684b532-5
0.647

View
Cc1ccncc1NC(=O)C(C)c1cccc(C2(F)CC2)c1

DAR-DIA-0cde14eb-12
0.634

View
Cc1ccncc1NC(=O)C(C)c1cccc(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-11
0.634

View
Cc1ccncc1NC(=O)C(C)c1ccccc1

TRY-UNI-714a760b-17
0.629

View
Cc1ccncc1NC(=O)C(C)c1ccccc1

AHN-SAT-202241f6-1
0.629

View
Cc1ccncc1NC(=O)C(C)c1cccc(C2(C)CC2)c1

DAR-DIA-0cde14eb-10
0.620

View
CC(=O)Nc1cnccc1-c1cc(C)c(NC(=O)C(C)c2cccc(Cl)c2)cn1

MAK-UNK-f203cb68-12
0.615

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Cc1ccncc1NC(=O)C(C)c1cccc(C2(I)CC2)c1

DAR-DIA-0cde14eb-13
0.611

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CCCC(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

JAN-GHE-83b26c96-8
0.606

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Cc1ccncc1NC(=O)C(c1ccccc1)c1cccc(Cl)c1

SAM-UNK-2684b532-1
0.606

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CC(=O)Nc1cnccc1Cc1ccncc1NC(=O)C(C)c1cccc(Cl)c1

MAK-UNK-f203cb68-2
0.603

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CC(C(=O)Nc1cnccc1-n1cccn1)c1cccc(Cl)c1

JAN-GHE-83b26c96-3
0.595

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Cc1c(N)cncc1NC(=O)C(C)c1cccc(Cl)c1

TRY-UNI-714a760b-15
0.594

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CC(=O)Nc1cnccc1-c1cncc(NC(=O)C(C)c2cccc(Cl)c2)c1C

MAK-UNK-f203cb68-13
0.590

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Cc1ccncc1NC(=O)C(C)c1cccc(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-15
0.587

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Cc1ccncc1NC(=O)c1ccc(C(C)C(=O)Nc2cnccc2C)cc1Cl

MAK-UNK-f203cb68-17
0.583

View
Cc1ccncc1NC(=O)c1cc(Cl)cc(C(C)C(=O)Nc2cnccc2C)c1

MAK-UNK-f203cb68-16
0.583

View
Cc1ccncc1NC(=O)CC(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

MAK-UNK-f203cb68-3
0.581

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CC(C)c1ncncc1NC(=O)C(C)c1cccc(Cl)c1

JAN-GHE-83b26c96-6
0.571

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Cc1nnc(C(C(=O)Nc2cnccc2C)c2cccc(Cl)c2)s1

SAM-UNK-2684b532-3
0.558

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Cc1nnc(C(C(=O)Nc2cnccc2C)c2cccc(Cl)c2)s1

TRY-UNI-9f475305-3
0.558

View
CC(=O)Nc1cnccc1-c1nccc(C)c1NC(=O)C(C)c1cccc(Cl)c1

MAK-UNK-f203cb68-11
0.554

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COc1ccccc1OC[C@H](C(=O)Nc1cnccc1C)c1cccc(Cl)c1

ADA-UCB-6c2cb422-9
0.542

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CC(=O)Nc1cnccc1-c1ccc(C(C)C(=O)Nc2cnccc2C)cc1Cl

MAK-UNK-f203cb68-8
0.538

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Cc1ccncc1NC(=O)C(C)c1cc(Cl)cc(OC2CC(=O)N2)c1

TRY-UNI-2eddb1ff-8
0.537

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CC(=O)Nc1cnccc1CC(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

MAK-UNK-f203cb68-1
0.537

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Cc1ccncc1NC(=O)Nc1cccc(Cl)c1

TRY-UNI-714a760b-12
0.529

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Cc1ccncc1NC(=O)Nc1cccc(Cl)c1

JAG-UCB-cedd89ab-8
0.529

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CC(=O)Nc1cnccc1-c1cc(Cl)cc(C(C)C(=O)Nc2cnccc2C)c1

MAK-UNK-f203cb68-7
0.525

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Cc1ccncc1NC(=O)Cc1cccc(Cl)c1

TRY-UNI-714a760b-6
0.522

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Cc1ccncc1NC(=O)C(=O)c1cccc(Cl)c1

MAK-UNK-6ca90168-24
0.522

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CO[C@@H](C)C(=O)Nc1cnccc1C

MAT-POS-590ac91e-2
0.516

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CO[C@H](C)C(=O)Nc1cnccc1C

MAT-POS-590ac91e-1
0.516

View
CO[C@H](C)C(=O)Nc1cnccc1C

ERI-UCB-5b47150d-1
0.516

View
Cc1ccncc1NC(=O)c1ccc(Cl)cc1C(C)C(=O)Nc1cnccc1C

MAK-UNK-f203cb68-15
0.513

View
Cc1ccncc1NC(=O)C(C)(C)c1cccc(Cl)c1

EDG-MED-0da5ad92-10
0.507

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Cc1ccncc1NC(=O)C(C)(C)c1cccc(Cl)c1

JAN-GHE-83b26c96-22
0.507

View
Cc1ccncc1NC(=O)C(C)c1cnn(C2(C)CC2)c1

DAR-DIA-0cde14eb-70
0.507

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CC(=O)Nc1cnccc1C(C(=O)C(C)c1cccc(Cl)c1)c1cnccc1C

MAK-UNK-f203cb68-10
0.500

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C(C)C(N)=O)c1

WIL-MOD-03b86a88-3
0.494

View
Cc1ccncc1NC(=O)C(C)c1cnn(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-71
0.494

View
Cc1ccncc1NC(=O)c1c(Cl)cccc1C(C)C(=O)Nc1cnccc1C

MAK-UNK-f203cb68-14
0.494

View
Cc1ccncc1NC(=O)N(C)c1cccc(Cl)c1

EDG-MED-0da5ad92-3
0.493

View
Cc1ccncc1NC(=O)N(c1cccc(Cl)c1)c1cccc(Cl)c1

EDG-MED-0da5ad92-19
0.493

View
Cc1ccncc1NC(=O)C(CO)c1ccccc1

BEN-DND-93268d01-3
0.493

View
COc1cccc(C(O)C(=O)Nc2cnccc2C)c1

BAR-COM-0f94fc3d-19
0.486

View
Cc1ccncc1NC(=O)C(C)(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

MAK-UNK-f203cb68-18
0.486

View
Cc1ccncc1NC(=O)[C@H](C)OC(F)F

MAT-POS-590ac91e-16
0.485

View
CC(=O)Nc1cnccc1-c1ccc(Cl)cc1C(C)C(=O)Nc1cnccc1C

MAK-UNK-f203cb68-6
0.481

View
Cc1ccncc1NC(=O)C(C)c1cnn(C2(F)CC2)c1

DAR-DIA-0cde14eb-72
0.481

View
Cc1ccncc1NC(=O)C(C)c1cnn(C2(I)CC2)c1

DAR-DIA-0cde14eb-73
0.481

View
Cc1ccncc1NC(=O)C(C)Cc1ccccc1

BEN-DND-93268d01-14
0.479

View
Cc1ccncc1NC(=N)Cc1cccc(Cl)c1

EDG-MED-0da5ad92-6
0.479

View
Cc1ccncc1NC(=O)C(F)c1ccccc1

ABI-SAT-4d06482b-1
0.478

View
Cc1ccncc1NC(=O)C(F)(F)c1cccc(Cl)c1

JAN-GHE-83b26c96-23
0.473

View
CC(=O)N[C@@H](C)C(=O)Nc1cnccc1C

MAT-POS-590ac91e-13
0.470

View
Cc1ccncc1NC(=O)C(C(=O)c1cc(=O)[nH]c2ccccc12)c1cccc(Cl)c1

ALP-POS-ddb41b15-1
0.467

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Cc1ccncc1NC(=O)C1(c2cccc(Cl)c2)CC1

JAN-GHE-83b26c96-20
0.467

View
Cc1ccncc1NC(=O)C1(c2cccc(Cl)c2)CC1

EDG-MED-0da5ad92-11
0.467

View
COCC(C(=O)Nc1cnccc1C)c1ccccc1

BEN-DND-93268d01-2
0.466

View
Cc1ccncc1NC(=O)C(C)c1cc(N2CCCCC2)cc(C2(F)CC2)c1

DAR-DIA-0cde14eb-27
0.465

View
Cc1ccncc1NC(=O)C(C)c1cc(N2CCCCC2)cc(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-26
0.460

View
CC(=O)Nc1cnccc1-c1c(Cl)cccc1C(C)C(=O)Nc1cnccc1C

MAK-UNK-f203cb68-5
0.458

View
Cc1ccncc1NC(=O)C(C)c1cnn(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-75
0.457

View
CCC(O)(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

BAR-COM-0f94fc3d-38
0.455

View
Cc1ccncc1NC(=O)C(C)c1cc(N2CCCCC2)cc(C2(C)CC2)c1

DAR-DIA-0cde14eb-25
0.453

View
Cc1ccncc1NC(=O)C1(c2cccc(Cl)c2)CC(=O)C1

BAR-COM-0f94fc3d-25
0.449

View
Cc1ccncc1NC(=O)N(c1ccccc1)c1cccc(Cl)c1

SAM-UNK-2684b532-2
0.449

View
Cc1ccncc1NC(=O)C(C)c1cc(N2CCCCC2)cc(C2(I)CC2)c1

DAR-DIA-0cde14eb-28
0.448

View
Cc1ccncc1NC(=O)[C@@H]1CC(=O)N(C)[C@@H]1c1cccc(Cl)c1

MAR-TRE-4b834d9a-26
0.447

View
Cc1ccncc1NC(=O)N(Cc1ccccc1)c1cccc(Cl)c1

EDG-MED-0da5ad92-20
0.446

View
Cc1ccncc1NC(=O)C(C)CC1CC1

MAT-POS-590ac91e-5
0.443

View
CC(=O)Nc1cnccc1C

AAR-POS-d2a4d1df-3
0.441

View
CC(=O)Nc1cnccc1C

MAK-UNK-6435e6c2-8
0.441

View
Cc1ccncc1NC(=O)C1CCN(Cc2cccc(Cl)c2)CC1

SAD-SAT-7d5528d9-7
0.440

View
Cc1ccncc1NC(=O)Cc1cccc(CO)c1

EDJ-MED-e58735b6-2
0.438

View
CC(C(=O)Nc1nncn1C1CC1)c1cccc(Cl)c1

BRU-CON-67e07230-1
0.436

View
Cc1ccncc1NS(=O)(=O)c1cccc(Cl)c1

JAN-GHE-83b26c96-21
0.431

View
Cc1ccncc1NC(=O)C(C)c1cc(N2CCCCC2)cc(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-30
0.429

View
Cc1ncncc1NC(=O)C(c1cccc(Cl)c1)C(C)C

JAN-GHE-83b26c96-7
0.429

View
CC(=O)Nc1cnccc1C(C)(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

MAK-UNK-f203cb68-9
0.429

View
Cc1ccncc1NS(=O)(=O)Cc1cccc(Cl)c1

JAN-GHE-83b26c96-17
0.427

View
Cc1ccncc1NC(=O)[C@H](CNS(C)(=O)=O)c1ccc(Cl)cc1

DAN-RED-da448e80-9
0.425

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

1.000

View
CC1=CC(C(C)C(=O)NC2=CN=CC=C2C)=CC=C1

0.710

View
COC1=CC=CC(C(C)C(=O)NC2=CN=CC=C2C)=C1

0.692

View
CC1=CN=CC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.688

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=CC(Br)=C1

0.688

View
CC(C(=O)NC1=CN=CC=C1O)C1=CC=CC(Cl)=C1

0.688

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=CC(F)=C1

0.688

View
CC1=CN=NC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.683

View
CC1=CC=NC=C1NC(=O)C(C1=CC=CC(Cl)=C1)C(C)C

0.677

View
CC(=O)NC1=CC=NC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.657

View
CC1=CC=NC=C1NC(=O)C(C1=CC=CC(Cl)=C1)N(C)C

0.657

View
COC1=CC=NC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.657

View
CSC1=CC=NC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.657

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=C(Cl)C(Cl)=C1

0.656

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=CC(C(F)(F)F)=C1

0.647

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=C(F)C(F)=C1

0.646

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=CC([N+](=O)[O-])=C1

0.638

View
CC(C(=O)NC1=CC=NC=C1Br)C1=CC=CC(Cl)=C1

0.636

View
CC1=CC(Cl)=NC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.636

View
CC(C(=O)NC1=CC=NC=C1I)C1=CC=CC(Cl)=C1

0.636

View
CC(C(=O)NC1=CC=NC=C1O)C1=CC=CC(Cl)=C1

0.636

View
CC1=CC(Br)=NC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.636

View
CCC(C(=O)NC1=CN=CC=C1C)C1=CC=CC(Cl)=C1

0.632

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=CC=C1

0.629

View
CC1=CC=NC=C1NC(=O)[C@@H](C)C1=CC=CC=C1

0.629

View
CC1=CC=NC=C1NC(=O)[C@H](C)C1=CC=CC=C1

0.629

View
CC(C(=O)NC1=CN=CC=C1OC(C)(C)C)C1=CC=CC(Cl)=C1

0.629

View
CC(C(=O)NC1=CC=NC=C1F)C1=CC=CC(Cl)=C1

0.627

View
CCC1=CN=CC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.618

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=CC(C(=O)C2=CC=CC=C2)=C1

0.611

View
CC1=CC=CC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.609

View
CC1=CC=NC=C1NC(=O)NC(C)C1=CC=CC(Cl)=C1

0.609

View
CC1=CC=NC=C1NC(=O)C(C)CC1=CC=CC(Cl)=C1

0.609

View
CCCC(C(=O)NC1=CN=CC=C1C)C1=CC=CC(Cl)=C1

0.606

View
CC(C(=O)NC1=CC=NC=C1C#N)C1=CC=CC(Cl)=C1

0.600

View
CC1=NC=CN1C1=CC=NC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.600

View
CC1=CSC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.600

View
CC(C(=O)NC1=CN=CC(Cl)=C1Cl)C1=CC=CC(Cl)=C1

0.597

View
CC(C(=O)NC1=CN=CC=C1N1C=CC=N1)C1=CC=CC(Cl)=C1

0.595

View
CC1=CC=NC=C1NC(=O)C(C)OC1=CC=CC(Cl)=C1

0.594

View
CC(=O)NC1=CC=C(C)C(NC(=O)C(C)C2=CC=CC(Cl)=C2)=C1

0.594

View
COC1=CC=C(C(C)C(=O)NC2=CN=CC=C2C)C=C1OC

0.594

View
CC(C(=O)NC1=CN=CC=C1N1CCN(C)CC1)C1=CC=CC(Cl)=C1

0.592

View
CC1=CC(C(F)(F)F)=NC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.592

View
CC(C(=O)NC1=CC=CC2=CC=NC=C12)C1=CC=CC(Cl)=C1

0.589

View
CC(C(=O)NC1=CC=CC2=CN=CC=C12)C1=CC=CC(Cl)=C1

0.589

View
CC1=NC=C(C)C(NC(=O)C(C)C2=CC=CC(Cl)=C2)=C1

0.588

View
CC1=CC=NC=C1C(C)NC(=O)C(C)C1=CC=CC(Cl)=C1

0.588

View
CC1=NN=CC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.588

View
CC1=CC=C(C(=O)O)C=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.588

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=C2C=CC=CC2=C1

0.586

View
CC1=CC=NC=C1NC(=O)C(OC1=CC=CC(Cl)=C1)C(C)C

0.586

View
CC1=CC=C(NC(=O)C(C)C)C=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.586

View
CC1=CN(C2=CC=NC=C2NC(=O)C(C)C2=CC=CC(Cl)=C2)N=C1

0.584

View
CC1=CC=C(C)C(NC(=O)C(C)C2=CC=CC(Cl)=C2)=C1

0.582

View
CC(C(=O)NC1=CC=CN=C1Cl)C1=CC=CC(Cl)=C1

0.582

View
CC1=CN=C(Cl)C(NC(=O)C(C)C2=CC=CC(Cl)=C2)=C1

0.580

View
CC(C(=O)NC1=CN=CC(Cl)=C1Br)C1=CC=CC(Cl)=C1

0.580

View
CC1=CC=C(C(C)C(=O)NC2=CN=CC=C2C)C=C1

0.578

View
CC1=CC=NC=C1NC(=O)N(C)C(C)C1=CC=CC(Cl)=C1

0.577

View
CC1=CC=NC=C1NC(=O)C(C)C1=C(Cl)C=CC=C1Cl

0.576

View
CC1=C(NC(=O)C(C)C2=CC=CC(Cl)=C2)C(C)=CN=C1

0.576

View
CC1=NC=CC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.574

View
CC1=C(NC(=O)C(C)C2=CC=CC(Cl)=C2)C=NN1C

0.574

View
CC1=CC=C(NC(=O)C(C)C2=CC=CC(Cl)=C2)C(Cl)=N1

0.574

View
CC(C)C1=NC=NC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.571

View
CC1=CC=NC=C1NC(=O)C(=O)NC(C)C1=CC=CC(Cl)=C1

0.569

View
CC(C(=O)NC1=CC=NC=C1)C1=CC=CC(Cl)=C1

0.569

View
CC1=CC=C(NC(=O)C(C)C2=CC=CC(Cl)=C2)C(C)=C1

0.567

View
CC1=C(C)C(NC(=O)C(C)C2=CC=CC(Cl)=C2)=CC=C1

0.567

View
CC(C(=O)NC1=CC=CN=C1)C1=CC=CC(Cl)=C1

0.567

View
CC1=C(NC(=O)C(C)C2=CC=CC(Cl)=C2)C(C)=NC=C1

0.567

View
CC1=CC=C(F)C=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.565

View
CC1=NC=C(NC(=O)C(C)C2=CC=CC(Cl)=C2)C(C)=N1

0.565

View
CC(C(=O)NC1=CC=NC2=CC=NC=C12)C1=CC=CC(Cl)=C1

0.560

View
CC1=CC(O)=CC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.559

View
CC(C(=O)NC1=CN=CC=N1)C1=CC=CC(Cl)=C1

0.559

View
CC1=C(F)C(NC(=O)C(C)C2=CC=CC(Cl)=C2)=CC=C1

0.559

View
CC1=NC(Cl)=CC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.559

View
CC1=C(O)C(NC(=O)C(C)C2=CC=CC(Cl)=C2)=CC=C1

0.559

View
CC1=C(Cl)C(NC(=O)C(C)C2=CC=CC(Cl)=C2)=CC=N1

0.557

View
CC1=CC=C(C(N)=O)C=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.557

View
CC1=CC=NC=C1CNC(=O)C(C)C1=CC=CC(Cl)=C1

0.556

View
CC1=CC=NC=C1NC(=O)C(=O)N(C)C(C)C1=CC=CC(Cl)=C1

0.554

View
CC1=CC(I)=CC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.551

View
CC1=CC=C(NC(=O)C(C)C2=CC=CC(Cl)=C2)C(C)=N1

0.551

View
CC1=CC(F)=CC=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.551

View
CC(C(=O)NC1=CN=CC2=CC=CC=C12)C1=CC=CC(Cl)=C1

0.548

View
CC1=CC=NC=C1NC(=O)NC(C1=CC=CC=C1)C1=CC=CC(Cl)=C1

0.547

View
CC1=CC=C(C#N)C=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.542

View
CC1=C(NC(=O)C(C)C2=CC=CC(Cl)=C2)C(C)=CC=C1

0.538

View
CC(C(=O)NC1=C(Cl)SC=C1)C1=CC=CC(Cl)=C1

0.537

View
CC1=CC=C(C(=O)N(C)C)C=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.534

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=C2OCCOC2=C1

0.533

View
CC1=CC=NC=C1NC(=O)C(C)C1=CC=C2OCOC2=C1

0.533

View
CC1=CC=NC=C1NC(=O)C(C)C(C)C(=O)NC1=CN=CC=C1C

0.517

View
CC1=CN=CC=C1CNC(=O)C(C)C1=CC=CC(Cl)=C1

0.514

View
CC1=CC=C(C2=CC=NN2C)C=C1NC(=O)C(C)C1=CC=CC(Cl)=C1

0.512

View
CC1=CC(C(C)C(=O)NC2=CC=NC=C2C)=CC=C1

0.479

View
CC1=CN=CC=C1NC(=O)C(C1=CC=CC(Cl)=C1)C(C)C

0.473

View
CC(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

1.000

View
CC(C(=O)Nc1cnccc1C)c1ccccc1

0.629

View
Cc1ccncc1NC(=O)Cc1cccc(Cl)c1

0.522

View
Cc1ccncc1NC(=O)Cc1ccc(Cl)cc1

0.423

View
Cc1ccncc1NC(=O)Cc1ccccc1

0.394

View
CC(C(=O)Nc1cccnc1)c1ccc(Cl)cc1

0.333

View
Clc1ccc(CC(=O)Nc2cccnc2)cc1Cl

0.217

View
C(NC1=C(C)C=CN=C1)(=O)C(C)C1=CC=C(Cl)C=C1

0.635

View
C(NC1=C(C)C=CN=C1)(=O)C(C)C1=CC=CC=C1

0.629

View
C(NC1=C(C)C=CN=C1)(=O)C(C1=CC=C(C)C=C1)C

0.578

View
C(NC1=C(C)C=CN=C1)(=O)C(C)C1=CC=C(F)C=C1

0.561

View
C(NC1=C(C)C=CN=C1)(=O)C(C)C1=CC=C(Br)C=C1

0.561

View
C(NC1=C(C)C=CN=C1)(=O)C(C1=CC=C(CC(C)C)C=C1)C

0.551

View
C(NC1=C(C)C=CN=C1)(=O)CC1=CC=CC(Cl)=C1

0.522

View
C(NC1=C(C)C=CN=C1)(=O)C(CC)C1=CC=CC=C1

0.465

View
C(NC1=C(C)C=CN=C1)(=O)CC1=CC=C(C(C)C)C=C1

0.431

View
C(NC1=C(C)C=CN=C1)(=O)CC1=C(Cl)C=CC=C1

0.425

View
C(NC1=C(C)C=CN=C1)(=O)CC1=CC=C(Cl)C=C1

0.423

View
C(NC1=CN=CC(Cl)=C1C)(=O)C(C)C1=CC=CC=C1

0.368

View
C(NC1=C(C)C(OC)=CN=C1)(=O)C(C)C1=CC=C(Cl)C=C1

0.354

View
C(NC1=CN=CC(Cl)=C1C)(=O)C(C)C1=CC=C(Cl)C=C1

0.351

View
C(NC1=CN=CC(C#N)=C1C)(=O)C(C)C1=CC=C(Cl)C=C1

0.350

View
C(NC1=CC=CN=C1)(=O)C(C)C1=CC=C(Cl)C=C1

0.333

View
C(NC1=CN=CC(Cl)=C1C)(=O)C(C1=CC=C(C)C=C1)C

0.333

View
C(NC1=CN=CC(Cl)=C1C)(=O)C(C)C1=CC=C(Br)C=C1

0.329

View
C(NC1=CN=CC(Cl)=C1C)(=O)C(C)C1=CC=C(F)C=C1

0.325

View
C(NC1=CN=C(Cl)C=C1)(=O)C(C)C1=CC=C(Cl)C=C1

0.282

View

Discussion: