Molecule Details

Cc1ccncc1NC(=O)C(C)Cc1ccccc1
Enamine Mcule Assayed
Molecular Properties
SMILES:
Cc1ccncc1NC(=O)C(C)Cc1ccccc1
MW: 254.14
Fraction sp3: 0.25
HBA: 2
HBD: 1
Rotatable Bonds: 4
TPSA: 41.99
cLogP: 3.21
Covalent Warhead:
Covalent Fragment:
Source
Enamine REAL: Z1182403201
Enamine Extended REAL: s_22____3391102____4781200
Mcule: MCULE-1024223009
Activity Data
Average Inhibition @ 20 µM - Fluorescence: -54.8602145
Average Inhibition @ 50 µM - Fluorescence: -127.91988
Relative Solubility @ 20 µM: 1.0
Relative Solubility @ 100 µM: 1.0
Order Status
Ordered: 2020-05-17
Synthesis Location: enamine
Shipped: 2020-06-24
CS(=O)(=O)NCCc1ccccc1

AAR-POS-d2a4d1df-1

View

Cc1ccncc1NC(=O)C(C)c1ccccc1

AHN-SAT-202241f6-1
0.581

View
Cc1ccncc1NC(=O)C(C)c1ccccc1

TRY-UNI-714a760b-17
0.581

View
Cc1ccncc1NC(=O)C(CO)c1ccccc1

BEN-DND-93268d01-3
0.562

View
Cc1ccncc1NC(=O)C(C)CC1CC1

MAT-POS-590ac91e-5
0.556

View
COCC(C(=O)Nc1cnccc1C)c1ccccc1

BEN-DND-93268d01-2
0.552

View
Cc1ccncc1NC(=O)Cc1ccccc1

TRY-UNI-714a760b-5
0.548

View
Cc1ccncc1NC(=O)C(F)c1ccccc1

ABI-SAT-4d06482b-1
0.547

View
CO[C@H](C)C(=O)Nc1cnccc1C

ERI-UCB-5b47150d-1
0.542

View
CO[C@H](C)C(=O)Nc1cnccc1C

MAT-POS-590ac91e-1
0.542

View
CO[C@@H](C)C(=O)Nc1cnccc1C

MAT-POS-590ac91e-2
0.542

View
Cc1ccncc1NC(=O)C(CNS(C)(=O)=O)c1ccccc1

DRE-WAB-eb790b7a-1
0.493

View
Cc1ccncc1NC(=O)[C@@H](CNS(C)(=O)=O)c1ccccc1

PED-UNI-5b7f1100-1
0.493

View
Cc1ccncc1NC(=O)[C@@H](CNS(C)(=O)=O)c1ccccc1

PED-UNI-8d53fd73-1
0.493

View
Cc1ccncc1NC(=O)[C@H](CNS(C)(=O)=O)c1ccccc1

DAN-RED-da448e80-1
0.493

View
CC(=O)N[C@@H](C)C(=O)Nc1cnccc1C

MAT-POS-590ac91e-13
0.492

View
Cc1ccncc1NC(=O)Nc1ccccc1

TRY-UNI-714a760b-4
0.484

View
Cc1ccncc1NC(=O)[C@@H](C)OC(F)F

MAT-POS-5d20d11c-1
0.484

View
Cc1ccncc1NC(=O)[C@H](C)OC(F)F

MAT-POS-590ac91e-16
0.484

View
Cc1ccncc1NC(=O)Nc1ccccc1

ALE-HEI-f28a35b5-1
0.484

View
Cc1ccncc1NC(=O)C(c1ccccc1)c1cccc(Cl)c1

SAM-UNK-2684b532-1
0.480

View
Cc1ccncc1NC(=O)[C@H](C)c1cccc(Cl)c1

TRY-UNI-2eddb1ff-5
0.479

View
Cc1ccncc1NC(=O)[C@@H](C)c1cccc(Cl)c1

TRY-UNI-2eddb1ff-4
0.479

View
Cc1ccncc1NC(=O)[C@H](C)c1cccc(Cl)c1

JAN-GHE-83b26c96-4
0.479

View
Cc1ccncc1NC(=O)[C@@H](C)c1cccc(Cl)c1

JAN-GHE-83b26c96-5
0.479

View
Cc1ccncc1NC(=O)C(C)c1cccc(Cl)c1

TRY-UNI-714a760b-18
0.479

View
Cc1ccncc1NC(=O)C(c1cccc(Cl)c1)C(C)C

JAN-GHE-83b26c96-9
0.472

View
Cc1ccncc1NC(=O)C(CO)c1cccc(Cl)c1

EDG-MED-0da5ad92-5
0.472

View
CC(=O)Nc1cnccc1C

MAK-UNK-6435e6c2-8
0.464

View
CC(=O)Nc1cnccc1C

AAR-POS-d2a4d1df-3
0.464

View
Cc1ccncc1NC(=O)C(C)c1cccc(C#N)c1

TRY-UNI-714a760b-22
0.453

View
COC(=O)C(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

MAT-POS-1e5f28a7-1
0.453

View
Cc1ccncc1NC(=O)C(C)c1cncc(Cl)c1

TRY-UNI-2eddb1ff-3
0.451

View
Cc1ccncc1NC(=O)C(CN1CCC(O)CC1)c1ccccc1

SAM-UNK-2684b532-10
0.450

View
Cc1ccncc1NC(=O)CC(C)C(C)C

MAT-POS-590ac91e-11
0.446

View
Cc1ccncc1NC(=O)CC#N

ASH-SAT-43770c7d-9
0.444

View
Cc1ccncc1NC(=O)C(C)C1CCCCC1

TRY-UNI-714a760b-16
0.443

View
CC(=O)N1CCN(C(C)C(=O)Nc2cnccc2C)CC1

BEN-DND-6de5dfa0-10
0.443

View
Cc1ccncc1NC(=O)CCl

MAK-UNK-6ca90168-26
0.443

View
CCCC(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

JAN-GHE-83b26c96-8
0.442

View
Cc1ccncc1NC(=O)C(c1cccc(Cl)c1)N(C)C

JAN-GHE-83b26c96-10
0.440

View
Cc1ccncc1NC(=O)Cc1cccc(CO)c1

EDJ-MED-e58735b6-2
0.437

View
Cc1ccncc1NC(=O)CC(C)(C)c1ccccc1

BEN-DND-93268d01-13
0.437

View
Cc1ccncc1NC(=O)Cc1cccc(F)c1

ALP-POS-95b75b4d-1
0.431

View
Cc1ccncc1NC(=O)C(C#N)CC1CC1

MAT-POS-590ac91e-14
0.431

View
Cc1ccncc1NC(=O)C(C)c1cccc(C2(F)CC2)c1

DAR-DIA-0cde14eb-12
0.430

View
CC(=O)N1CCN(C(C(=O)Nc2cnccc2C)c2cccc(Cl)c2)CC1

VLA-UCB-05e51b3f-2
0.427

View
COc1cccc(C(O)C(=O)Nc2cnccc2C)c1

BAR-COM-0f94fc3d-19
0.427

View
Cc1ccncc1NC(=O)CC1(CO)CC1

MAT-POS-590ac91e-6
0.426

View
C=CC(=O)Nc1cnccc1C

MAK-UNK-6ca90168-27
0.426

View
Cc1ccncc1NC(=O)CC(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

MAK-UNK-f203cb68-3
0.425

View
Cc1ccncc1NC(=O)NCCBr

ALE-HEI-f28a35b5-13
0.424

View
Cc1ccncc1NC(=O)Cc1ccccc1N

ANN-UNI-98d2bf15-1
0.423

View
Cc1ccncc1NC(=O)NC1(Oc2ccccc2)CCC1

CHR-SOS-1f323c23-7
0.421

View
Cc1ccncc1NC(=O)CC(CNS(C)(=O)=O)c1ccccc1

PET-SGC-d5b502b1-1
0.418

View
Cc1ccncc1NC(=O)C(C)c1cccc(C2(C)CC2)c1

DAR-DIA-0cde14eb-10
0.418

View
Cc1ccncc1NC(=O)c1c(Cl)cccc1C(C)C(=O)Nc1cnccc1C

MAK-UNK-f203cb68-14
0.418

View
Cc1ccncc1NC(=O)CN1CCN(C(=O)c2ccccc2)CC1

BEN-DND-6de5dfa0-2
0.418

View
Cc1ccncc1NC(=O)CC(CNS(C)(=O)=O)c1ccccc1

WIL-WAB-6ef46ddb-1
0.418

View
Cc1ccncc1NC(=O)Cc1cccc(O)c1

ALP-POS-95b75b4d-2
0.417

View
Cc1ccncc1NC(=O)Cc1cccc(I)c1

JAN-GHE-83b26c96-13
0.417

View
Cc1ccncc1NC(=O)Cc1cccc(Cl)c1

TRY-UNI-714a760b-6
0.417

View
Cc1ccncc1NC(=O)C(CCc1ccccc1)c1cc(Cl)cc(OC2CC(=O)N2)c1

ALP-POS-3fc1724e-6
0.417

View
Cc1ccncc1NC(=O)NC1(Oc2ccccc2)CCCC1

CHR-SOS-1f323c23-4
0.416

View
Cc1ccncc1NC(=O)C(C(=O)C(C)c1cccc(Cl)c1)c1cnccc1C

MAK-UNK-f203cb68-19
0.415

View
Cc1ccncc1NC(=O)Cc1ccsc1

MIH-UNI-6b9ca91a-1
0.414

View
Cc1ccncc1NC(=O)NC1(Oc2ccccc2)CC1

CHR-SOS-1f323c23-10
0.413

View
CC(=O)N1CCN(C(C(=O)Nc2cnccc2C)c2ccsc2)CC1

MAK-UNK-902cc841-17
0.412

View
Cc1ccncc1NC(=O)C(C)c1cccc(C2(I)CC2)c1

DAR-DIA-0cde14eb-13
0.412

View
Cc1ccncc1NC(=O)C(C)c1cccc(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-11
0.412

View
Cc1ccc(CC(=O)Nc2cnccc2C)cc1

JAN-GHE-83b26c96-11
0.412

View
CC(=O)Nc1cnccc1CC(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

MAK-UNK-f203cb68-1
0.412

View
Cc1ccncc1NC(=O)Cc1cccc(Br)c1

JAN-GHE-83b26c96-12
0.411

View
Cc1ccncc1NC(=O)[C@H](CNS(C)(=O)=O)c1cccs1

DAN-RED-da448e80-17
0.410

View
Cc1ccncc1NC(=O)C(C)c1cnn(C2(C)CC2)c1

DAR-DIA-0cde14eb-70
0.410

View
Cc1ccncc1NC(=O)N(Cc1ccccc1)c1cccc(Cl)c1

EDG-MED-0da5ad92-20
0.410

View
Cc1ccncc1NC(=O)CN1CCOCC1

BEN-DND-93268d01-10
0.408

View
Cc1ccncc1NC(=O)Cc1cccc(C#N)c1

TRY-UNI-714a760b-20
0.408

View
Cc1ccncc1NC(=O)CNC(=O)Cc1cccnc1

GAB-REV-70cc3ca5-13
0.405

View
Cc1ccncc1NC(=O)c1cc(Cl)cc(C(C)C(=O)Nc2cnccc2C)c1

MAK-UNK-f203cb68-16
0.405

View
Cc1ccncc1NC(=O)[C@H](CNS(C)(=O)=O)c1ccc(F)cc1

DAN-RED-da448e80-5
0.405

View
Cc1ccncc1NC(=O)[C@H](CNS(C)(=O)=O)c1ccc(Cl)cc1

DAN-RED-da448e80-9
0.405

View
Cc1ccncc1NC(=O)c1ccc(C(C)C(=O)Nc2cnccc2C)cc1Cl

MAK-UNK-f203cb68-17
0.405

View
Cc1ccncc1NC(=O)C(C)c1cnn(C2(I)CC2)c1

DAR-DIA-0cde14eb-73
0.405

View
Cc1ccncc1NC(=O)C(C)c1cnn(C2(F)CC2)c1

DAR-DIA-0cde14eb-72
0.405

View
Cc1ccncc1NC(=O)NC1(Oc2ccccc2)CCCCC1

CHR-SOS-1f323c23-1
0.405

View
COc1ccccc1OC[C@H](C(=O)Nc1cnccc1C)c1cccc(Cl)c1

ADA-UCB-6c2cb422-9
0.404

View
Cc1ccncc1NC(=O)CCCBr

ALE-HEI-f28a35b5-12
0.403

View
Cc1ccncc1NC(=O)NCCCC(N)N

ALE-HEI-f28a35b5-11
0.403

View
CC(=O)N1CCN(CC(=O)Nc2cnccc2C)CC1

BEN-DND-93268d01-8
0.403

View
Cc1ccncc1NC(=O)Cc1cccc([S+](C)[O-])c1

DAR-DIA-0cde14eb-78
0.403

View
COc1cccc(CC(=O)Nc2cnccc2C)c1

EDJ-MED-e58735b6-1
0.400

View
Cc1ccncc1NC(=O)CCc1ccccc1F

BEN-DND-93268d01-7
0.400

View
Cc1ccncc1NC(=O)NC1CCCCC1

TRY-UNI-714a760b-11
0.400

View
Cc1ccncc1NC(=O)C(C)c1cnn(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-71
0.400

View
Cc1ccncc1NC(=O)CNC1(c2ccccc2)CCCCC1

WAR-XCH-e55cba98-11
0.400

View
Cc1ccncc1NC(=O)CC(O)C1CC1

MAT-POS-590ac91e-7
0.400

View
CC(=O)N1CCN(C(C(=O)Nc2cnccc2C)c2cccs2)CC1

MAK-UNK-902cc841-15
0.400

View
Cc1ccncc1NC(=O)NC1CCCCC1

ALE-HEI-f28a35b5-7
0.400

View
Cc1nnc(NC(=O)Nc2cnccc2C)s1

ALE-HEI-f28a35b5-2
0.400

View
Cc1ccncc1NC(=O)C(C)c1cccc(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-15
0.398

View
Cc1ccncc1NC(=O)C(C)Cc1ccccc1

1.000

View
Cc1ccncc1NC(=O)[C@H](C)Cc1ccccc1

1.000

View
Cc1ccncc1NC(=O)C(C)Cc1ccncc1

0.850

View
Cc1ccc(CC(C)C(=O)Nc2cnccc2C)cc1

0.810

View
Cc1cnccc1NC(=O)[C@H](C)Cc1ccccc1

0.810

View
Cc1cnccc1NC(=O)C(C)Cc1ccccc1

0.810

View
Cc1ccncc1NC(=O)C(C)CCCc1ccccc1

0.778

View
Cc1ccncc1NC(=O)C(C)Cc1ccc(F)cc1

0.773

View
Cc1ccncc1NC(=O)C(Cc1ccccc1)C(C)C

0.773

View
Cc1ccncc1NC(=O)C(C)Cc1ccc(Br)cc1

0.773

View
Cc1ccncc1NC(=O)C(F)Cc1ccccc1

0.767

View
Cc1ccncc1NC(=O)C(C)Cc1cccc(Cl)c1

0.761

View
Cc1ccncc1NC(=O)[C@@H](O)Cc1ccccc1

0.750

View
Cc1ccccc1CC(C)C(=O)Nc1cnccc1C

0.750

View
CC(Cc1ccccc1)C(=O)Nc1cnccc1O

0.750

View
C[C@H](Cc1ccccc1)C(=O)Nc1cnccc1O

0.750

View
Cc1ccncc1NC(=O)C(C)Cc1cccc(F)c1

0.745

View
COc1ccc(CC(C)C(=O)Nc2cnccc2C)cc1

0.739

View
CC(=O)Nc1ccncc1NC(=O)C(C)Cc1ccccc1

0.733

View
CC(=O)Nc1ccncc1NC(=O)[C@H](C)Cc1ccccc1

0.733

View
C[C@H](Cc1ccccc1)C(=O)Nc1cnccc1-c1ccccc1

0.733

View
CCC(Cc1ccccc1)C(=O)Nc1cnccc1C

0.733

View
CC(Cc1ccccc1)C(=O)Nc1cnccc1-c1ccccc1

0.733

View
CNC(Cc1ccccc1)C(=O)Nc1cnccc1C

0.733

View
CC(Cc1ccccc1)C(=O)Nc1ccncc1Br

0.727

View
C[C@H](Cc1ccccc1)C(=O)Nc1ccncc1Br

0.727

View
Cc1ccncc1NC(=O)C(C)Cc1ccc(C(F)(F)F)cc1

0.723

View
Cc1ccncc1NC(=O)C(C)CSCc1ccccc1

0.723

View
Cc1cnncc1NC(=O)C(C)Cc1ccccc1

0.721

View
Cc1cnncc1NC(=O)[C@H](C)Cc1ccccc1

0.721

View
Cc1ccccc1NC(=O)C(C)Cc1ccncc1

0.721

View
COC(Cc1ccccc1)C(=O)Nc1cnccc1C

0.717

View
COc1ccncc1NC(=O)C(C)Cc1ccccc1

0.717

View
COc1ccncc1NC(=O)[C@H](C)Cc1ccccc1

0.717

View
CSc1ccncc1NC(=O)C(C)Cc1ccccc1

0.717

View
CSc1ccncc1NC(=O)[C@H](C)Cc1ccccc1

0.717

View
Cc1ccncc1NC(=O)C(CN)Cc1ccccc1

0.717

View
CC(Cc1ccccc1)C(=O)Nc1ccncc1F

0.711

View
C[C@H](Cc1ccccc1)C(=O)Nc1ccncc1F

0.711

View
CC(Cc1ccccc1)C(=O)Nc1ccncc1I

0.711

View
C[C@H](Cc1ccccc1)C(=O)Nc1ccncc1I

0.711

View
CC(Cc1ccccc1)C(=O)Nc1ccncc1O

0.711

View
C[C@H](Cc1ccccc1)C(=O)Nc1ccncc1O

0.711

View
CCOc1ccc(CC(C)C(=O)Nc2cnccc2C)cc1

0.708

View
Cc1ccccc1NC(=O)C(C)Cc1ccccc1

0.707

View
Cc1ccncc1NC(=O)C(C)CC(C)C(=O)Nc1cnccc1C

0.707

View
Cc1ccccc1NC(=O)[C@H](C)Cc1ccccc1

0.707

View
CC(Cc1ccccc1)C(=O)Nc1cnccc1C(F)(F)F

0.702

View
C[C@H](Cc1ccccc1)C(=O)Nc1cnccc1C(F)(F)F

0.702

View
Cc1ccncc1NC(=O)C(Cc1ccccc1)NC(N)=O

0.702

View
Cc1ccncc1NC(=O)C(C)Cc1ccccc1F

0.702

View
Cc1ccncc1NC(=O)C(C)Cc1ccccc1Cl

0.702

View
Cc1ccncc1NC(=O)C(C)Cc1cnn(C)c1

0.702

View
CC(Cc1ccccc1)C(=O)Nc1cnccc1OC(C)(C)C

0.702

View
C[C@H](Cc1ccccc1)C(=O)Nc1cnccc1OC(C)(C)C

0.702

View
CCNC(Cc1ccccc1)C(=O)Nc1cnccc1C

0.702

View
Cc1ccncc1NC(=O)C(C)Cc1cccc(C(F)(F)F)c1

0.700

View
CCCC(C)C(=O)Nc1cnccc1C

0.698

View
CC(=O)c1cnccc1NC(=O)[C@H](C)Cc1ccccc1

0.696

View
CCc1cnccc1NC(=O)C(C)Cc1ccccc1

0.696

View
CCc1cnccc1NC(=O)[C@H](C)Cc1ccccc1

0.696

View
Cc1ccncc1NC(=O)C(C)CSc1ccccc1

0.696

View
Cc1ccncc1NC(=O)C(=O)NC(Cc1ccccc1)Cc1ccccc1

0.696

View
Cc1ccncc1NC(=O)C(C)Cc1ccc(OC(F)(F)F)cc1

0.694

View
CCC(C)C(=O)Nc1cnccc1C

0.690

View
Cc1ccc(-c2ccncc2)cc1NC(=O)C(C)Cc1ccccc1

0.688

View
Cc1ccc(-c2ccncc2)cc1NC(=O)[C@H](C)Cc1ccccc1

0.688

View
CC(Cc1ccccc1)C(=O)Nc1cnccc1Oc1ccccc1

0.688

View
C[C@H](Cc1ccccc1)C(=O)Nc1cnccc1Oc1ccccc1

0.688

View
Cc1ccncc1NC(=O)C(Cc1ccccc1)NC(=O)c1ccccc1

0.688

View
Cc1ccncc1NC(=O)C(C)CCOc1ccccc1

0.688

View
Cc1ccncc1NC(=O)C(C)Cc1ccc(F)c(F)c1

0.688

View
Cc1ccncc1NC(=O)C(=O)NC(Cc1ccccc1)C(C)C

0.688

View
Cc1cnccc1NC(=O)C(C)Cc1ccncc1

0.682

View
CC(Cc1ccccc1)C(=O)Nc1ccncc1C#N

0.681

View
C[C@H](Cc1ccccc1)C(=O)Nc1ccncc1C#N

0.681

View
CC(C)C(=O)c1cnccc1NC(=O)[C@H](C)Cc1ccccc1

0.681

View
Cc1ccncc1NC(=O)C(C)OCc1ccccc1

0.681

View
Cc1ccncc1NC(=O)C(C)SCc1ccccc1

0.681

View
Cc1ccncc1NC(=O)[C@H](C)OCc1ccccc1

0.681

View
Cc1ccncc1NC(=O)C(C)Cc1ccco1

0.681

View
Cc1nccn1-c1ccncc1NC(=O)[C@H](C)Cc1ccccc1

0.680

View
Cc1nccn1-c1ccncc1NC(=O)C(C)Cc1ccccc1

0.680

View
Cc1ccc(-c2cccnc2)cc1NC(=O)C(C)Cc1ccccc1

0.680

View
Cc1ccc(-c2cccnc2)cc1NC(=O)[C@H](C)Cc1ccccc1

0.680

View
Cc1cncc(C)c1NC(=O)C(C)Cc1ccccc1

0.674

View
Cc1cncc(C)c1NC(=O)[C@H](C)Cc1ccccc1

0.674

View
Cc1ccncc1NC(=O)C(C)CN

0.674

View
Cc1ncncc1NC(=O)C(C)Cc1ccccc1

0.674

View
Cc1ncncc1NC(=O)[C@H](C)Cc1ccccc1

0.674

View
Cc1ccncc1NC(=O)C(C)Cc1cnc[nH]1

0.674

View
Cc1ccncc1NC(=O)NC(Cc1ccccc1)Cc1ccccc1

0.674

View
Cc1ccc(CC(C)C(=O)Nc2cnccc2-c2ccccc2)cc1

0.673

View
Cc1ccncc1NC(=O)C(C)Cc1cnc2ccccc2n1

0.673

View
CNC(=O)C(Cc1ccccc1)NC(=O)C(=O)Nc1cnccc1C

0.673

View
Cc1ccncc1NC(=O)C(=O)NCC(Cc1ccccc1)C(C)C

0.673

View
CC(Cc1ccccc1)C(=O)Nc1cccc2ccncc12

0.667

View
CC(Cc1ccccc1)C(=O)Nc1ccnc2ccncc12

0.667

View
C[C@H](Cc1ccccc1)C(=O)Nc1ccnc2ccncc12

0.667

View
C[C@H](Cc1ccccc1)C(=O)Nc1cccc2ccncc12

0.667

View

C(NC1=C(C)C=CN=C1)(=O)CCC1=CC=CC=C1

0.874

View
C(NC1=C(C)C=CN=C1)(=O)C1C(C2=CC=CC=C2)C1

0.859

View
C(NC1=C(C)C=CN=C1)(=O)C(CSC(C)=O)CC1=CC=CC=C1

0.821

View
C(NC1=C(C)C=CN=C1)(=O)CC(C)C1=CC=CC=C1

0.818

View
C(NC1=C(C)C=CN=C1)(=O)CCC1=CC=C(F)C=C1

0.818

View


Discussion: