Molecule Details

Cc1ccncc1NC(=O)CC1CC2(CC2)C1
3-aminopyridine-like Enamine Assayed
Molecular Properties
SMILES:
Cc1ccncc1NC(=O)CC1CC2(CC2)C1
MW: 230.14
Fraction sp3: 0.57
HBA: 2
HBD: 1
Rotatable Bonds: 3
TPSA: 41.99
cLogP: 2.91
Covalent Warhead:
Covalent Fragment:
Source
Enamine REAL: Z3471768079
Enamine Extended REAL: s_22____3391102____15352730
Activity Data
Average Inhibition @ 20 µM - Fluorescence: -10.3198815
Average Inhibition @ 50 µM - Fluorescence: 14.486355
Average Inhibition @ 50 µM - RapidFire: 2.50792320615296
Relative Solubility @ 20 µM: 1.0
Relative Solubility @ 100 µM: 1.0
Order Status
Ordered: 2020-05-17
Synthesis Location: enamine
Shipped: 2020-06-30
CS(=O)(=O)NCCc1ccccc1

AAR-POS-d2a4d1df-1

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Cc1ccncc1NC(=O)CC1CCCCC1

TRY-UNI-714a760b-10
0.617

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Cc1ccncc1NC(=O)CC1CC2CC2C1

MAT-POS-590ac91e-23
0.617

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Cc1ccncc1NC(=O)CC1CCCCC1

ALE-HEI-f28a35b5-6
0.617

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Cc1ccncc1NC(=O)CC1CCCCC1

EDG-MED-0da5ad92-4
0.617

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Cc1ccncc1NC(=O)CC1CCCNC1

EDG-MED-0da5ad92-9
0.569

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Cc1ccncc1NC(=O)CCl

MAK-UNK-6ca90168-26
0.536

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Cc1ccncc1NC(=O)CC1(CO)CC1

MAT-POS-590ac91e-6
0.532

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COC1(CC(=O)Nc2cnccc2C)CC1

MAT-POS-590ac91e-9
0.524

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Cc1ccncc1NC(=O)CC1(C#N)CCC1

MAT-POS-590ac91e-15
0.523

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Cc1ccncc1NC(=O)CC12CCCC1C2

MAT-POS-590ac91e-25
0.515

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Cc1ccncc1NC(=O)CC#N

ASH-SAT-43770c7d-9
0.508

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Cc1ccncc1NC(=O)CCCBr

ALE-HEI-f28a35b5-12
0.508

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Cc1ccncc1NC(=O)CCOC1CC1

MAT-POS-590ac91e-10
0.508

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Cc1ccncc1NC(=O)CC(O)C1CC1

MAT-POS-590ac91e-7
0.500

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Cc1ccncc1NC(=O)C1CCC2(CC2)C1

MAT-POS-590ac91e-21
0.500

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Cc1nnc(CC(=O)Nc2cnccc2C)s1

ALE-HEI-f28a35b5-3
0.492

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Cc1ccncc1NC(=O)Cc1ccccc1

TRY-UNI-714a760b-5
0.492

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Cc1ccc(CC(=O)Nc2cnccc2C)cc1

JAN-GHE-83b26c96-11
0.492

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C=CC(=O)Nc1cnccc1C

MAK-UNK-6ca90168-27
0.491

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Cc1ccncc1NC(=O)CC(C)C(C)C

MAT-POS-590ac91e-11
0.484

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CC(=O)Nc1cnccc1C

MAK-UNK-6435e6c2-8
0.481

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CC(=O)Nc1cnccc1C

AAR-POS-d2a4d1df-3
0.481

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Cc1ccncc1NC(=O)Cc1nc2cccc(C)c2o1

GAB-REV-70cc3ca5-23
0.473

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Cc1ccncc1NC(=O)Cc1ccsc1

MIH-UNI-6b9ca91a-1
0.470

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Cc1ccncc1NC(=O)CN1CCN(C)CC1

BEN-DND-93268d01-9
0.470

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Cc1ccncc1NC(=O)C1CCC12CCC2

MAT-POS-590ac91e-22
0.470

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Cc1ccncc1NC(=O)CN1CCCCC1

BEN-DND-93268d01-11
0.470

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Cc1ccncc1NC(=O)Cc1cccc(C2(C)CC2)c1

DAR-DIA-0cde14eb-1
0.466

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Cc1ccncc1NC(=O)Cc1cnn(C2(I)CC2)c1

DAR-DIA-0cde14eb-64
0.466

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Cc1ccncc1NC(=O)Cc1cnn(C2(C)CC2)c1

DAR-DIA-0cde14eb-61
0.466

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Cc1cc(CC(=O)Nc2cnccc2C)[nH]n1

EDJ-MED-c9f55a56-1
0.463

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Cc1ccncc1NC(=O)CN1CCOCC1

BEN-DND-93268d01-10
0.463

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Cc1ccncc1NC(=O)C[C@@H]1CC[C@H](C(N)=O)[C@@H]1c1ccsc1

PET-SGC-a3e47117-1
0.462

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Cc1ccncc1NC(=O)CCCCC(=N)N

PET-SGC-6e7c5dc0-1
0.462

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Cc1ccncc1NC(=O)Cc1cccc(C2(F)CC2)c1

DAR-DIA-0cde14eb-2
0.459

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Cc1ccncc1NC(=O)Cc1cnn(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-62
0.459

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Cc1ccncc1NC(=O)Cc1cnn(C2(F)CC2)c1

DAR-DIA-0cde14eb-63
0.459

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Cc1ccncc1NC(=O)Cc1cncc(Cl)c1

TRY-UNI-2eddb1ff-2
0.456

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Cc1ccncc1NC(=O)Cc1ccccc1N

ANN-UNI-98d2bf15-1
0.456

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Cc1ccncc1NC(=O)CCc1ccn[nH]1

MAT-POS-590ac91e-17
0.456

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CC(=O)N1CCN(CC(=O)Nc2cnccc2C)CC1

BEN-DND-93268d01-8
0.456

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Cc1ccncc1NC(=O)Cc1cncc(Cl)c1

EDG-MED-0da5ad92-8
0.456

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Cc1ccncc1NC(=O)C(C)CC1CC1

MAT-POS-590ac91e-5
0.455

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Cc1ccncc1NC(=O)Cc1cccc(C2(I)CC2)c1

DAR-DIA-0cde14eb-4
0.453

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Cc1ccncc1NC(=O)Cc1cccc(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-3
0.453

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Cc1ccncc1NC(=O)CCc1ccccc1F

BEN-DND-93268d01-7
0.451

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COc1cccc(CC(=O)Nc2cnccc2C)c1

EDJ-MED-e58735b6-1
0.451

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Cc1ccncc1NC(=O)Cc1cccc(I)c1

JAN-GHE-83b26c96-13
0.449

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Cc1ccncc1NC(=O)Cc1cccc(Cl)c1

TRY-UNI-714a760b-6
0.449

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Cc1ccncc1NC(=O)Cc1cccc(O)c1

ALP-POS-95b75b4d-2
0.449

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Cc1ccncc1NC(=O)Cc1ccc(S(N)(=O)=O)cc1

GAB-REV-70cc3ca5-20
0.449

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Cc1ccncc1NC(=O)CCc1ccc(F)cc1

BEN-DND-93268d01-5
0.449

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Cc1ccncc1NC(=O)Cc1cccc(CO)c1

EDJ-MED-e58735b6-2
0.449

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(NC23CC(C2)C3)c1

MAT-POS-e501d84c-1
0.449

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CC(=O)Nc1ccc(NCC(=O)Nc2cnccc2C)cc1

GAB-REV-70cc3ca5-21
0.448

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Cc1ccncc1NC(=O)Cc1cccc(C2CC2)c1

ALP-POS-95b75b4d-4
0.446

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Cc1ccncc1NC(=O)Cc1cccc(C(F)(F)F)c1

ALP-POS-95b75b4d-3
0.444

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Cc1ccncc1NC(=O)Cc1cccc(C(F)(F)F)c1

JAN-GHE-83b26c96-14
0.444

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Cc1ccncc1NC(=O)Cc1cccc(C(F)(F)F)c1

DAR-DIA-0cde14eb-76
0.444

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Cc1ccncc1NC(=O)Cc1cccc(Br)c1

JAN-GHE-83b26c96-12
0.443

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Cc1ccncc1NC(=O)Cc1cccc(F)c1

ALP-POS-95b75b4d-1
0.443

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Cc1ccncc1NC(=O)CCc1ccccn1

BEN-DND-93268d01-4
0.443

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Cc1ccncc1NC(=O)CCSCCS(C)(=O)=O

MAK-UNK-372b0df5-3
0.443

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Cc1ccncc1NC(=O)Cc1cnn(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-74
0.442

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Cc1ccncc1NC(=O)C12CC(CO1)C2

MAT-POS-590ac91e-4
0.441

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Cc1ccncc1NC(=O)[C@H]1C[C@](O)(C#N)C1

MAT-POS-590ac91e-26
0.441

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Cc1ccncc1NC(=O)CCCCC(N)N

ALE-HEI-f28a35b5-10
0.441

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Cc1ccncc1NC(=O)C12CCC(CO1)C2

MAT-POS-590ac91e-29
0.437

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Cc1ccncc1NC(=O)CNC(=O)Cc1cccnc1

GAB-REV-70cc3ca5-13
0.437

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Cc1ccncc1NC(=O)Cc1cccc(C2(C#N)CC2)c1

DAR-DIA-0cde14eb-14
0.436

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Cc1ccncc1NC(=O)[C@@]12COC[C@@H]1C2

MAT-POS-590ac91e-3
0.435

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(NC2CCC(F)(F)C2O)c1

MAT-POS-044491d2-2
0.434

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Cc1ccncc1NC(=O)[C@@H]1C[C@H]1CF

ERI-UCB-5b47150d-6
0.433

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Cc1ccncc1NC(=O)Cc1cccc([S+](C)[O-])c1

DAR-DIA-0cde14eb-78
0.432

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CNC(=O)COC1(CC(=O)Nc2cnccc2C)CCN(C)CC1

SIM-DEM-2d7ee9fd-1
0.430

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Cc1ccncc1NC(=O)Cc1nc2ncccc2o1

GAB-REV-70cc3ca5-11
0.429

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Cc1ccncc1NC(=O)Cc1cc(Cl)cc(CNS(C)(=O)=O)c1

RAL-THA-6b94ceba-12
0.429

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Cc1ccncc1NC(=O)CNC1(c2ccccc2)CCCCC1

WAR-XCH-e55cba98-11
0.429

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(-c2ccc(C3CC3(F)F)cc2)c1

MAT-POS-f42f3716-1
0.429

View
Cc1ccncc1NC(=O)CC(C)(C)c1ccccc1

BEN-DND-93268d01-13
0.429

View
Cc1ccncc1NC(=O)Cc1cccc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-7
0.425

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Cc1ccncc1NC(=O)Cc1cccc(OC2CC(=O)N2)c1

BRU-LEF-c49414a7-1
0.425

View
Cc1ccncc1NC(=O)Cc1cncc(C#N)c1

TRY-UNI-2eddb1ff-1
0.425

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Cc1ccncc1NC(=O)Cc1cccc(C(N)=O)c1

ANN-UNI-98d2bf15-2
0.425

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Cc1ccncc1NC(=O)CCc1cccc(Cl)c1

ALP-POS-f13221e1-4
0.425

View
Cc1ccncc1NC(=O)C(C#N)CC1CC1

MAT-POS-590ac91e-14
0.423

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CC(C(=O)Nc1cnccc1C)=C1CC1

ERI-UCB-5b47150d-4
0.422

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Cc1ccncc1NC(=O)Cc1ccccc1Cc1ccccn1

THO-SYG-cc9e9a11-1
0.421

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Cc1ccncc1NC(=O)Cc1ccc2[nH]ncc2c1

VLA-UCB-00f2c2b3-2
0.421

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CNC(=O)c1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-7
0.421

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Cc1ccncc1NC(=O)Cc1nc2ccccc2[nH]1

GAB-REV-70cc3ca5-9
0.421

View
Cc1ccncc1NC(=O)Cc1cccc(C#N)c1

TRY-UNI-714a760b-20
0.419

View
Cc1ccncc1NC(=O)CCc1cccc(F)c1

BEN-DND-93268d01-6
0.419

View
Cc1ccncc1NC(=O)C1CC(C2CC2)C1

MAT-POS-590ac91e-18
0.418

View
Cc1ccncc1NC(=O)[C@@H]1[C@H]2CCCC[C@H]21

MAT-POS-590ac91e-19
0.418

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C2COC2)c1

WIL-MOD-03b86a88-2
0.418

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(-c2ncc[nH]2)c1

RAL-THA-6b94ceba-9
0.418

View
Cc1ccncc1NC(=O)CCSCC(NC=O)S(C)(=O)=O

MAK-UNK-372b0df5-2
0.416

View
Cc1ccncc1NC(=O)Cc1ccccc1-c1ccccn1

THO-SYG-cc9e9a11-2
0.416

View
Cc1ccncc1NC(=O)Cc1ccc2[nH]ccc2c1

VLA-UCB-00f2c2b3-1
0.416

View
Cc1ccncc1NC(=O)CC1CC(F)(F)C1

0.773

View
Cc1ccncc1NC(=O)CC1CC1

0.738

View
Cc1ccncc1NC(=O)CC1CC(=O)C1

0.727

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Cc1ccncc1NC(=O)CC1CCC(C)(C)CC1

0.717

View
Cc1ccncc1NC(=O)CC1CC(=O)NC(=O)C1

0.711

View
Cc1ccncc1NC(=O)CC1CCC(F)(F)C1

0.708

View
Cc1ccncc1NC(=O)C[C@@H]1CC2(CC2)CN1

0.708

View
Cc1ccncc1NC(=O)CC1CCCC1

0.705

View
Cc1ccncc1NC(=O)CC1CCC1

0.705

View
Cc1ccncc1NC(=O)CC1CCC(F)(F)CC1

0.702

View
Cc1ccncc1NC(=O)CC1CCCCC1

0.689

View
Cc1ccncc1NC(=O)CC1CCCCCC1

0.689

View
Cc1ccncc1NC(=O)CC1CCOC(C)(C)C1

0.680

View
Cc1ccncc1NC(=O)CC1CCC(C)CC1

0.674

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Cc1ccncc1NC(=O)CC1CC1(Cl)Cl

0.674

View
Cc1ccncc1NC(=O)CC1CS(=O)(=O)C1

0.674

View
Cc1ccncc1NC(=O)CC1CCNCC1

0.674

View
Cc1ccncc1NC(=O)CC1CCC2(CC1)OCCO2

0.673

View
Cc1ccncc1NC(=O)CC1CC(C)CC(C)(C)C1

0.660

View
Cc1ccncc1NC(=O)CC1CCOCC1

0.660

View
Cc1ccncc1NC(=O)CC1CCSCC1

0.660

View
Cc1ccncc1NC(=O)C[C@H]1CC[C@@H](N)CC1

0.660

View
Cc1ccncc1NC(=O)C[C@@H]1CCNC1

0.660

View
Cc1ccncc1NC(=O)C[C@H]1CCNC1

0.660

View
CCOC1CC(CC(=O)Nc2cnccc2C)C1

0.653

View
Cc1ccncc1NC(=O)CC1CC=CCC1

0.646

View
Cc1ccncc1NC(=O)CC1CCC(C)C1

0.646

View
Cc1ccncc1NC(=O)CC1CCS(=O)(=O)CC1

0.646

View
Cc1ccncc1NC(=O)CC1CC(c2ccccc2)C1

0.646

View
Cc1ccncc1NC(=O)CC1CC2CCC(C1)N2

0.646

View
Cc1ccncc1NC(=O)CC1(C)CC1

0.644

View
Cc1ccncc1NC(=O)NC1CC2(CC2)C1

0.638

View
Cc1ccncc1NC(=O)CC1CCOC1

0.633

View
Cc1ccncc1NC(=O)C[C@H]1CCOC1

0.633

View
Cc1ccncc1NC(=O)CC1CCC(C(C)(C)C)CC1

0.633

View
COC1CCC(CC(=O)Nc2cnccc2C)CC1

0.633

View
Cc1ccncc1NC(=O)CC1CCC(C(=O)O)CC1

0.633

View
Cc1ccncc1NC(=O)CC1CCCNC1

0.633

View
Cc1ccncc1NC(=O)C[C@H]1CCCNC1

0.633

View
Cc1ccncc1NC(=O)C[C@@H]1CCCNC1

0.633

View
Cc1ccncc1NC(=O)CC1(CC(=O)Nc2cnccc2C)CCCC1

0.630

View
Cc1ccncc1NC(=O)CC1CC1C

0.630

View
CCOC(=O)C1CCC(CC(=O)Nc2cnccc2C)CC1

0.627

View
Cc1ccncc1NC(=O)CC1(C(F)(F)F)CC1

0.625

View
Cc1cnccc1NC(=O)CC1CC(F)(F)C1

0.625

View
Cc1ccncc1NC(=O)C(=O)NC1CC2(CC2)C1

0.625

View
Cc1ccncc1NC(=O)CC1CCS(=O)(=O)C1

0.620

View
Cc1ccncc1NC(=O)CC1CCCC(C)C1

0.620

View
Cc1ccncc1NC(=O)CC1CCC(c2ccccc2)CC1

0.620

View
Cc1ccncc1NC(=O)CC1COC(=O)C1

0.620

View
Cc1ccncc1NC(=O)CC1CCC(=O)NC1

0.620

View
Cc1ccncc1NC(=O)CC1(CC(=O)Nc2cnccc2C)CCCCC1

0.617

View
Cc1ccncc1NC(=O)CC1CC(=O)N1

0.617

View
Cc1ccncc1NC(=O)CC1(C)CCCC1

0.617

View
Cc1ccncc1NC(=O)CC1OCCO1

0.617

View
Cc1ccncc1NC(=O)CC1CCCOC1

0.608

View
Cc1ccncc1NC(=O)CC1CCCCC1(C)C

0.608

View
Cc1ccncc1NC(=O)CC1CCN(S(C)(=O)=O)CC1

0.608

View
Cc1ccncc1NC(=O)CC1OCCC1(C)C

0.608

View
Cc1ccncc1NC(=O)C[C@@H]1CC2(CC2)CN1C(=O)OC(C)(C)C

0.607

View
Cc1ccncc1NC(=O)CC12CC3CC(CC(C3)C1)C2

0.604

View
Cc1ccncc1NC(=O)C1CC2(CCC2)C1

0.604

View
Cc1ccncc1NC(=O)CC1(O)CCCC1

0.604

View
Cc1ccncc1NC(=O)CC1(C)CCCCC1

0.604

View
Cc1ccncc1NC(=O)CC1(O)CCC1

0.604

View
Cc1ccncc1NC(=O)CC1(N)CCC1

0.604

View
Cc1ccncc1NC(=O)CC1(CN)CC1

0.604

View
Cc1ccncc1NC(=O)CNC(=O)CC1CCCC1

0.600

View
Cc1ccncc1NC(=O)CC1CCc2ccccc2C1

0.596

View
Cc1ccncc1NC(=O)CC1CCCNC(=O)C1

0.596

View
CCON1CCC(CC(=O)Nc2cnccc2C)CC1

0.596

View
Cc1ccncc1NC(=O)CCC1CC1

0.596

View
Cc1ccncc1NC(=O)CCC1(CCC(=O)Nc2cnccc2C)CC1

0.596

View
Cc1ccncc1NC(=O)COCC1CC1

0.592

View
Cc1ccncc1NC(=O)CC1(O)CCCCC1

0.592

View
Cc1ccncc1NC(=O)CC1OCCCO1

0.592

View
Cc1ccncc1NC(=O)C1CC2(CCCCC2)C1

0.592

View
COC1(CC(=O)Nc2cnccc2C)CCC1

0.592

View
Cc1ccncc1NC(=O)CC1(C#N)CC1

0.592

View
Cc1ccncc1NC(=O)NNC(=O)CC1CC1

0.592

View
Cc1ccncc1NC(=O)NCC1CC(C)(C)C1

0.592

View
Cc1ccncc1NC(=O)CC1(CC(=O)O)CC1

0.592

View
Cc1ccncc1NC(=O)CNC(=O)CC1CCCCC1

0.588

View
Cc1ccncc1NC(=O)CC1CCCC(=O)N1

0.588

View
CC(=O)[C@@H]1C[C@H](CC(=O)Nc2cnccc2C)C1(C)C

0.588

View
Cc1ccncc1NC(=O)CC1C=CS(=O)(=O)C1

0.588

View
Cc1ccncc1NC(=O)C1CCC2(CC1)CC(N)C2

0.588

View
Cc1cnccc1NC(=O)CC1CC1

0.587

View
Cc1ccncc1NC(=O)CC1CN(C(=O)OC(C)(C)C)C1

0.585

View
Cc1ccncc1NC(=O)CC1CCN(CC(F)F)CC1

0.585

View
COC1CCCC(CC(=O)Nc2cnccc2C)C1

0.585

View
Cc1ccncc1NC(=O)CC1CCN(CC(F)(F)F)CC1

0.585

View
Cc1ccncc1NC(=O)CCC1(C)CC1

0.583

View
Cc1ccncc1NC(=O)C1CCC2(CC1)CC2

0.583

View
Cc1cnccc1NC(=O)CC1CC(=O)C1

0.583

View
Cc1ccncc1NC(=O)NCC1CC=CC1

0.583

View
Cc1ccncc1NC(=O)CN

0.581

View
Cc1ccncc1NC(=O)CCl

0.581

View
Cc1ccncc1NC(=O)CC1C=CCC1

0.580

View
Cc1ccncc1NC(=O)CC1CCCC1C

0.580

View
Cc1ncccc1NC(=O)CC1CCCCC1

0.197

View
O=C(Nc1cccnc1)C1CC12CCCCC2

0.196

View
CC1(C)C[C@@H]1C(=O)Nc1cnccc1CO

0.190

View
CCC(C)C(C)C(=O)Nc1cnccc1CO

0.188

View
O=C(CC1CC2CCC1C2)Nc1cccnc1

0.184

View
O=C(CC1CCCCC1)Nc1cccnc1

0.168

View
O=C(CC1CCCC1)Nc1cccnc1

0.168

View
O=C(CC12CC3CC(CC(C3)C1)C2)Nc1cccnc1

0.165

View
O=C(CC1CC1)Nc1cnccc1CO

0.151

View
CC(=O)CCCC(=O)Nc1cnccc1C

0.141

View
Cc1ccncc1N(C)C(=O)CC1(C)CC1

0.130

View
Cc1ccncc1NC(=O)CCC1CCCC1

0.104

View
C(NC1=C(C)C=CN=C1)(=O)CC1CCC(C)CC1

0.886

View
C(NC1=C(C)C=CN=C1)(=O)CCC1CC(C)C1

0.874

View
C(NC1=C(C)C=CN=C1)(=O)CC1CCCCC1

0.870

View
C(NC1=C(C)C=CN=C1)(=O)CC12CC3CC(CC(C3)C1)C2

0.866

View
C(NC1=C(C)C=CN=C1)(=O)C1CC2(CC2)C1

0.865

View


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