Submission Details

Molecule(s):
CO[C@H](C)C(=O)Nc1cnccc1C

MAT-POS-590ac91e-1

CO[C@H](C)C(=O)Nc1cnccc1C

CO[C@@H](C)C(=O)Nc1cnccc1C

MAT-POS-590ac91e-2

CO[C@@H](C)C(=O)Nc1cnccc1C

Cc1ccncc1NC(=O)[C@@]12COC[C@@H]1C2

MAT-POS-590ac91e-3

Cc1ccncc1NC(=O)[C@@]12COC[C@@H]1C2

Cc1ccncc1NC(=O)C12CC(CO1)C2

MAT-POS-590ac91e-4

Cc1ccncc1NC(=O)C12CC(CO1)C2

Cc1ccncc1NC(=O)C(C)CC1CC1

MAT-POS-590ac91e-5

Cc1ccncc1NC(=O)C(C)CC1CC1

Cc1ccncc1NC(=O)CC1(CO)CC1

MAT-POS-590ac91e-6

Cc1ccncc1NC(=O)CC1(CO)CC1

3-aminopyridine-like Ordered Check Availability on Manifold View
Cc1ccncc1NC(=O)CC(O)C1CC1

MAT-POS-590ac91e-7

Cc1ccncc1NC(=O)CC(O)C1CC1

CCO[C@@H]1C[C@H]1C(=O)Nc1cnccc1C

MAT-POS-590ac91e-8

CCO[C@@H]1C[C@H]1C(=O)Nc1cnccc1C

COC1(CC(=O)Nc2cnccc2C)CC1

MAT-POS-590ac91e-9

COC1(CC(=O)Nc2cnccc2C)CC1

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1ccncc1NC(=O)CCOC1CC1

MAT-POS-590ac91e-10

Cc1ccncc1NC(=O)CCOC1CC1

Cc1ccncc1NC(=O)CC(C)C(C)C

MAT-POS-590ac91e-11

Cc1ccncc1NC(=O)CC(C)C(C)C

Cc1ccncc1NC(=O)[C@@H]1CNC(=O)O1

MAT-POS-590ac91e-12

Cc1ccncc1NC(=O)[C@@H]1CNC(=O)O1

CC(=O)N[C@@H](C)C(=O)Nc1cnccc1C

MAT-POS-590ac91e-13

CC(=O)N[C@@H](C)C(=O)Nc1cnccc1C

Cc1ccncc1NC(=O)CC1(C#N)CCC1

MAT-POS-590ac91e-15

Cc1ccncc1NC(=O)CC1(C#N)CCC1

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1NC(=O)[C@H](C)OC(F)F

MAT-POS-590ac91e-16

Cc1ccncc1NC(=O)[C@H](C)OC(F)F

Cc1ccncc1NC(=O)CCc1ccn[nH]1

MAT-POS-590ac91e-17

Cc1ccncc1NC(=O)CCc1ccn[nH]1

Cc1ccncc1NC(=O)C1CC(C2CC2)C1

MAT-POS-590ac91e-18

Cc1ccncc1NC(=O)C1CC(C2CC2)C1

Cc1ccncc1NC(=O)[C@@H]1[C@H]2CCCC[C@H]21

MAT-POS-590ac91e-19

Cc1ccncc1NC(=O)[C@@H]1[C@H]2CCCC[C@H]21

Cc1ccnc(C)c1NC(=O)C1CC2CC2C1

MAT-POS-590ac91e-20

Cc1ccnc(C)c1NC(=O)C1CC2CC2C1

Cc1ccncc1NC(=O)C1CCC2(CC2)C1

MAT-POS-590ac91e-21

Cc1ccncc1NC(=O)C1CCC2(CC2)C1

Cc1ccncc1NC(=O)C1CCC12CCC2

MAT-POS-590ac91e-22

Cc1ccncc1NC(=O)C1CCC12CCC2

Cc1ccncc1NC(=O)CC1CC2CC2C1

MAT-POS-590ac91e-23

Cc1ccncc1NC(=O)CC1CC2CC2C1

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1ccncc1NC(=O)CC1CC2(CC2)C1

MAT-POS-590ac91e-24

Cc1ccncc1NC(=O)CC1CC2(CC2)C1

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1ccncc1NC(=O)CC12CCCC1C2

MAT-POS-590ac91e-25

Cc1ccncc1NC(=O)CC12CCCC1C2

Cc1ccncc1NC(=O)[C@H]1C[C@](O)(C#N)C1

MAT-POS-590ac91e-26

Cc1ccncc1NC(=O)[C@H]1C[C@](O)(C#N)C1

Cc1ccncc1NC(=O)C1(C#N)CCOC1

MAT-POS-590ac91e-27

Cc1ccncc1NC(=O)C1(C#N)CCOC1

Cc1ccncc1NC(=O)C1C2CCOCC21

MAT-POS-590ac91e-28

Cc1ccncc1NC(=O)C1C2CCOCC21

Cc1ccncc1NC(=O)C12CCC(CO1)C2

MAT-POS-590ac91e-29

Cc1ccncc1NC(=O)C12CCC(CO1)C2

O=C(NCC1COc2ccccc2O1)c1cc(=O)[nH]c2ccc(F)cc12

MAT-POS-590ac91e-30

O=C(NCC1COc2ccccc2O1)c1cc(=O)[nH]c2ccc(F)cc12

O=C(NCC1COc2ccccc2O1)c1cc(=O)[nH]c2cc(F)ccc12

MAT-POS-590ac91e-31

O=C(NCC1COc2ccccc2O1)c1cc(=O)[nH]c2cc(F)ccc12

COc1ccccc1OCCNC(=O)c1cc(=O)[nH]c2cc(F)ccc12

MAT-POS-590ac91e-32

COc1ccccc1OCCNC(=O)c1cc(=O)[nH]c2cc(F)ccc12

CN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2ccc(F)cc12

MAT-POS-590ac91e-33

CN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2ccc(F)cc12

CN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2cc(F)ccc12

MAT-POS-590ac91e-34

CN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2cc(F)ccc12

COc1cccc2c1OCC(NC(=O)c1cc(=O)[nH]c3ccc(F)cc13)C2

MAT-POS-590ac91e-35

COc1cccc2c1OCC(NC(=O)c1cc(=O)[nH]c3ccc(F)cc13)C2

COc1cccc2c1OCC(NC(=O)c1cc(=O)[nH]c3cc(F)ccc13)C2

MAT-POS-590ac91e-36

COc1cccc2c1OCC(NC(=O)c1cc(=O)[nH]c3cc(F)ccc13)C2

COc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2cc(F)ccc12

MAT-POS-590ac91e-37

COc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2cc(F)ccc12

COc1ccccc1OC(C)CNC(=O)c1cc(=O)[nH]c2cc(F)ccc12

MAT-POS-590ac91e-38

COc1ccccc1OC(C)CNC(=O)c1cc(=O)[nH]c2cc(F)ccc12

COc1ccccc1OC(C)CNC(=O)c1cc(=O)[nH]c2ccc(F)cc12

MAT-POS-590ac91e-39

COc1ccccc1OC(C)CNC(=O)c1cc(=O)[nH]c2ccc(F)cc12

COc1ccccc1OCC(C)NC(=O)c1cc(=O)[nH]c2cc(F)ccc12

MAT-POS-590ac91e-40

COc1ccccc1OCC(C)NC(=O)c1cc(=O)[nH]c2cc(F)ccc12

COc1ccccc1OCC(C)NC(=O)c1cc(=O)[nH]c2ccc(F)cc12

MAT-POS-590ac91e-41

COc1ccccc1OCC(C)NC(=O)c1cc(=O)[nH]c2ccc(F)cc12

COc1ccccc1OCCNC(=O)c1cc(=O)[nH]c2ccc(Cl)cc12

MAT-POS-590ac91e-42

COc1ccccc1OCCNC(=O)c1cc(=O)[nH]c2ccc(Cl)cc12

COc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2ccc(Cl)cc12

MAT-POS-590ac91e-43

COc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2ccc(Cl)cc12

COc1ccccc1OC1CCCN(C(=O)c2c(C)c(=O)[nH]c3ccccc23)C1

MAT-POS-590ac91e-44

COc1ccccc1OC1CCCN(C(=O)c2c(C)c(=O)[nH]c3ccccc23)C1

CCOc1ccccc1OC1CCN(C(=O)c2c(C)c(=O)[nH]c3ccccc23)C1

MAT-POS-590ac91e-45

CCOc1ccccc1OC1CCN(C(=O)c2c(C)c(=O)[nH]c3ccccc23)C1

CC1(C)Cc2cccc(OCCNC(=O)c3cc(=O)[nH]c4cc(F)ccc34)c2O1

MAT-POS-590ac91e-46

CC1(C)Cc2cccc(OCCNC(=O)c3cc(=O)[nH]c4cc(F)ccc34)c2O1

CC1(C)Cc2cccc(OCCNC(=O)c3cc(=O)[nH]c4ccc(F)cc34)c2O1

MAT-POS-590ac91e-47

CC1(C)Cc2cccc(OCCNC(=O)c3cc(=O)[nH]c4ccc(F)cc34)c2O1

CCOc1ccccc1OC1CCN(C(=O)c2cc(=O)[nH]c3ccc(F)cc23)C1

MAT-POS-590ac91e-48

CCOc1ccccc1OC1CCN(C(=O)c2cc(=O)[nH]c3ccc(F)cc23)C1

CCOc1ccccc1OC1CCN(C(=O)c2cc(=O)[nH]c3cc(F)ccc23)C1

MAT-POS-590ac91e-49

CCOc1ccccc1OC1CCN(C(=O)c2cc(=O)[nH]c3cc(F)ccc23)C1

CCCN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2cc(F)ccc12

MAT-POS-590ac91e-50

CCCN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2cc(F)ccc12

CCN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2ccc(Cl)cc12

MAT-POS-590ac91e-51

CCN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2ccc(Cl)cc12

CCN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2ccc([N+](=O)[O-])cc12

MAT-POS-590ac91e-52

CCN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2ccc([N+](=O)[O-])cc12

CC1(C)Cc2cccc(OCCNC(=O)c3cc(=O)[nH]c4ccc(Cl)cc34)c2O1

MAT-POS-590ac91e-53

CC1(C)Cc2cccc(OCCNC(=O)c3cc(=O)[nH]c4ccc(Cl)cc34)c2O1

COc1ccccc1OC1CCCN(C(=O)c2cc(=O)[nH]c3ccc(Cl)cc23)C1

MAT-POS-590ac91e-54

COc1ccccc1OC1CCCN(C(=O)c2cc(=O)[nH]c3ccc(Cl)cc23)C1

CCCN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2ccc(Cl)cc12

MAT-POS-590ac91e-55

CCCN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2ccc(Cl)cc12

O=C(c1cc(=O)[nH]c2ccc(F)cc12)N1CCN(S(=O)(=O)c2ccccc2)CC1

MAT-POS-590ac91e-56

O=C(c1cc(=O)[nH]c2ccc(F)cc12)N1CCN(S(=O)(=O)c2ccccc2)CC1

O=C(c1cc(=O)[nH]c2cc(F)ccc12)N1CCN(S(=O)(=O)c2ccccc2)CC1

MAT-POS-590ac91e-57

O=C(c1cc(=O)[nH]c2cc(F)ccc12)N1CCN(S(=O)(=O)c2ccccc2)CC1

O=C(c1cc(=O)[nH]c2ccc(Cl)cc12)N1CCN(S(=O)(=O)c2ccccc2)CC1

MAT-POS-590ac91e-58

O=C(c1cc(=O)[nH]c2ccc(Cl)cc12)N1CCN(S(=O)(=O)c2ccccc2)CC1

N#Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4ccc(F)cc34)CC2)cc1

MAT-POS-590ac91e-59

N#Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4ccc(F)cc34)CC2)cc1

N#Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4cc(F)ccc34)CC2)cc1

MAT-POS-590ac91e-60

N#Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4cc(F)ccc34)CC2)cc1

N#Cc1ccccc1S(=O)(=O)N1CCN(C(=O)c2cc(=O)[nH]c3cc(F)ccc23)CC1

MAT-POS-590ac91e-61

N#Cc1ccccc1S(=O)(=O)N1CCN(C(=O)c2cc(=O)[nH]c3cc(F)ccc23)CC1

N#Cc1ccccc1S(=O)(=O)N1CCN(C(=O)c2cc(=O)[nH]c3ccc(F)cc23)CC1

MAT-POS-590ac91e-62

N#Cc1ccccc1S(=O)(=O)N1CCN(C(=O)c2cc(=O)[nH]c3ccc(F)cc23)CC1

Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4cc(F)ccc34)CC2)c(C)c1

MAT-POS-590ac91e-63

Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4cc(F)ccc34)CC2)c(C)c1

Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4ccc(F)cc34)CC2)c(C)c1

MAT-POS-590ac91e-64

Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4ccc(F)cc34)CC2)c(C)c1

COc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4cc(F)ccc34)CC2)cc1

MAT-POS-590ac91e-65

COc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4cc(F)ccc34)CC2)cc1

Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4ccc(Cl)cc34)CC2)cc1

MAT-POS-590ac91e-66

Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4ccc(Cl)cc34)CC2)cc1

O=C(c1cc(=O)[nH]c2ccc(F)cc12)N1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1

MAT-POS-590ac91e-67

O=C(c1cc(=O)[nH]c2ccc(F)cc12)N1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1

O=C(c1cc(=O)[nH]c2ccc(F)cc12)N1CCN(S(=O)(=O)c2ccccc2Cl)CC1

MAT-POS-590ac91e-68

O=C(c1cc(=O)[nH]c2ccc(F)cc12)N1CCN(S(=O)(=O)c2ccccc2Cl)CC1

O=C(c1cc(=O)[nH]c2ccc(F)cc12)N1CCN(S(=O)(=O)c2cccc(Cl)c2)CC1

MAT-POS-590ac91e-69

O=C(c1cc(=O)[nH]c2ccc(F)cc12)N1CCN(S(=O)(=O)c2cccc(Cl)c2)CC1

O=C(c1cc(=O)[nH]c2ccc(Cl)cc12)N1CCN(S(=O)(=O)c2ccccc2F)CC1

MAT-POS-590ac91e-70

O=C(c1cc(=O)[nH]c2ccc(Cl)cc12)N1CCN(S(=O)(=O)c2ccccc2F)CC1


Design Rationale:

Enamine REAL analogs of IC50 amino-pyridine hits as well as the MAT-POS-916a2c5a-2 and MAT-POS-916a2c5a-3 Submission is on behalf of Matt and Bruce Lefker who did the by-eye picking of Matt's high throughput search.

Other Notes:

no fragments used.

Inspired By:
Discussion: