CO[C@H](C)C(=O)Nc1cnccc1C
CO[C@@H](C)C(=O)Nc1cnccc1C
Cc1ccncc1NC(=O)[C@@]12COC[C@@H]1C2
Cc1ccncc1NC(=O)C12CC(CO1)C2
Cc1ccncc1NC(=O)C(C)CC1CC1
Cc1ccncc1NC(=O)CC1(CO)CC1
Cc1ccncc1NC(=O)CC(O)C1CC1
CCO[C@@H]1C[C@H]1C(=O)Nc1cnccc1C
COC1(CC(=O)Nc2cnccc2C)CC1
Cc1ccncc1NC(=O)CCOC1CC1
Cc1ccncc1NC(=O)CC(C)C(C)C
Cc1ccncc1NC(=O)[C@@H]1CNC(=O)O1
CC(=O)N[C@@H](C)C(=O)Nc1cnccc1C
Cc1ccncc1NC(=O)C(C#N)CC1CC1
Cc1ccncc1NC(=O)CC1(C#N)CCC1
Cc1ccncc1NC(=O)[C@H](C)OC(F)F
Cc1ccncc1NC(=O)CCc1ccn[nH]1
Cc1ccncc1NC(=O)C1CC(C2CC2)C1
Cc1ccncc1NC(=O)[C@@H]1[C@H]2CCCC[C@H]21
Cc1ccnc(C)c1NC(=O)C1CC2CC2C1
Cc1ccncc1NC(=O)C1CCC2(CC2)C1
Cc1ccncc1NC(=O)C1CCC12CCC2
Cc1ccncc1NC(=O)CC1CC2CC2C1
Cc1ccncc1NC(=O)CC1CC2(CC2)C1
Cc1ccncc1NC(=O)CC12CCCC1C2
Cc1ccncc1NC(=O)[C@H]1C[C@](O)(C#N)C1
Cc1ccncc1NC(=O)C1(C#N)CCOC1
Cc1ccncc1NC(=O)C1C2CCOCC21
Cc1ccncc1NC(=O)C12CCC(CO1)C2
O=C(NCC1COc2ccccc2O1)c1cc(=O)[nH]c2ccc(F)cc12
O=C(NCC1COc2ccccc2O1)c1cc(=O)[nH]c2cc(F)ccc12
COc1ccccc1OCCNC(=O)c1cc(=O)[nH]c2cc(F)ccc12
CN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2ccc(F)cc12
CN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2cc(F)ccc12
COc1cccc2c1OCC(NC(=O)c1cc(=O)[nH]c3ccc(F)cc13)C2
COc1cccc2c1OCC(NC(=O)c1cc(=O)[nH]c3cc(F)ccc13)C2
COc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2cc(F)ccc12
COc1ccccc1OC(C)CNC(=O)c1cc(=O)[nH]c2cc(F)ccc12
COc1ccccc1OC(C)CNC(=O)c1cc(=O)[nH]c2ccc(F)cc12
COc1ccccc1OCC(C)NC(=O)c1cc(=O)[nH]c2cc(F)ccc12
COc1ccccc1OCC(C)NC(=O)c1cc(=O)[nH]c2ccc(F)cc12
COc1ccccc1OCCNC(=O)c1cc(=O)[nH]c2ccc(Cl)cc12
COc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2ccc(Cl)cc12
COc1ccccc1OC1CCCN(C(=O)c2c(C)c(=O)[nH]c3ccccc23)C1
CCOc1ccccc1OC1CCN(C(=O)c2c(C)c(=O)[nH]c3ccccc23)C1
CC1(C)Cc2cccc(OCCNC(=O)c3cc(=O)[nH]c4cc(F)ccc34)c2O1
CC1(C)Cc2cccc(OCCNC(=O)c3cc(=O)[nH]c4ccc(F)cc34)c2O1
CCOc1ccccc1OC1CCN(C(=O)c2cc(=O)[nH]c3ccc(F)cc23)C1
CCOc1ccccc1OC1CCN(C(=O)c2cc(=O)[nH]c3cc(F)ccc23)C1
CCCN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2cc(F)ccc12
CCN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2ccc(Cl)cc12
CCN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2ccc([N+](=O)[O-])cc12
CC1(C)Cc2cccc(OCCNC(=O)c3cc(=O)[nH]c4ccc(Cl)cc34)c2O1
COc1ccccc1OC1CCCN(C(=O)c2cc(=O)[nH]c3ccc(Cl)cc23)C1
CCCN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2ccc(Cl)cc12
O=C(c1cc(=O)[nH]c2ccc(F)cc12)N1CCN(S(=O)(=O)c2ccccc2)CC1
O=C(c1cc(=O)[nH]c2cc(F)ccc12)N1CCN(S(=O)(=O)c2ccccc2)CC1
O=C(c1cc(=O)[nH]c2ccc(Cl)cc12)N1CCN(S(=O)(=O)c2ccccc2)CC1
N#Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4ccc(F)cc34)CC2)cc1
N#Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4cc(F)ccc34)CC2)cc1
N#Cc1ccccc1S(=O)(=O)N1CCN(C(=O)c2cc(=O)[nH]c3cc(F)ccc23)CC1
N#Cc1ccccc1S(=O)(=O)N1CCN(C(=O)c2cc(=O)[nH]c3ccc(F)cc23)CC1
Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4cc(F)ccc34)CC2)c(C)c1
Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4ccc(F)cc34)CC2)c(C)c1
COc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4cc(F)ccc34)CC2)cc1
Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3cc(=O)[nH]c4ccc(Cl)cc34)CC2)cc1
O=C(c1cc(=O)[nH]c2ccc(F)cc12)N1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1
O=C(c1cc(=O)[nH]c2ccc(F)cc12)N1CCN(S(=O)(=O)c2ccccc2Cl)CC1
O=C(c1cc(=O)[nH]c2ccc(F)cc12)N1CCN(S(=O)(=O)c2cccc(Cl)c2)CC1
O=C(c1cc(=O)[nH]c2ccc(Cl)cc12)N1CCN(S(=O)(=O)c2ccccc2F)CC1
Enamine REAL analogs of IC50 amino-pyridine hits as well as the MAT-POS-916a2c5a-2 and MAT-POS-916a2c5a-3 Submission is on behalf of Matt and Bruce Lefker who did the by-eye picking of Matt's high throughput search.
no fragments used.