Submission Details

Molecule(s):
CCC(C(=O)Nc1cnncc1C)c1cccc(Cl)c1

JAN-GHE-83b26c96-1

CCC(C(=O)Nc1cnncc1C)c1cccc(Cl)c1

3-aminopyridine-like Assayed View
CC(=O)Nc1ccncc1NC(=O)C(C)c1cccc(Cl)c1

JAN-GHE-83b26c96-2

CC(=O)Nc1ccncc1NC(=O)C(C)c1cccc(Cl)c1

3-aminopyridine-like Enamine Assayed View
CC(C(=O)Nc1cnccc1-n1cccn1)c1cccc(Cl)c1

JAN-GHE-83b26c96-3

CC(C(=O)Nc1cnccc1-n1cccn1)c1cccc(Cl)c1

3-aminopyridine-like Enamine Assayed View
Cc1ccncc1NC(=O)[C@H](C)c1cccc(Cl)c1

JAN-GHE-83b26c96-4

Cc1ccncc1NC(=O)[C@H](C)c1cccc(Cl)c1

3-aminopyridine-like Ordered View
Cc1ccncc1NC(=O)[C@@H](C)c1cccc(Cl)c1

JAN-GHE-83b26c96-5

Cc1ccncc1NC(=O)[C@@H](C)c1cccc(Cl)c1

3-aminopyridine-like Ordered View
CC(C)c1ncncc1NC(=O)C(C)c1cccc(Cl)c1

JAN-GHE-83b26c96-6

CC(C)c1ncncc1NC(=O)C(C)c1cccc(Cl)c1

3-aminopyridine-like Assayed View
Cc1ncncc1NC(=O)C(c1cccc(Cl)c1)C(C)C

JAN-GHE-83b26c96-7

Cc1ncncc1NC(=O)C(c1cccc(Cl)c1)C(C)C

3-aminopyridine-like Enamine Assayed View
CCCC(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

JAN-GHE-83b26c96-8

CCCC(C(=O)Nc1cnccc1C)c1cccc(Cl)c1

3-aminopyridine-like Enamine Assayed View
Cc1ccncc1NC(=O)C(c1cccc(Cl)c1)C(C)C

JAN-GHE-83b26c96-9

Cc1ccncc1NC(=O)C(c1cccc(Cl)c1)C(C)C

3-aminopyridine-like Enamine Mcule Assayed View
Cc1ccncc1NC(=O)C(c1cccc(Cl)c1)N(C)C

JAN-GHE-83b26c96-10

Cc1ccncc1NC(=O)C(c1cccc(Cl)c1)N(C)C

3-aminopyridine-like Enamine Assayed View
Cc1ccc(CC(=O)Nc2cnccc2C)cc1

JAN-GHE-83b26c96-11

Cc1ccc(CC(=O)Nc2cnccc2C)cc1

3-aminopyridine-like Enamine Mcule Assayed View
Cc1ccncc1NC(=O)Cc1cccc(Br)c1

JAN-GHE-83b26c96-12

Cc1ccncc1NC(=O)Cc1cccc(Br)c1

3-aminopyridine-like Enamine Mcule Assayed View
Cc1ccncc1NC(=O)Cc1cccc(I)c1

JAN-GHE-83b26c96-13

Cc1ccncc1NC(=O)Cc1cccc(I)c1

3-aminopyridine-like Enamine Mcule Assayed View
Cc1ccncc1NC(=O)Cc1cccc(C(F)(F)F)c1

JAN-GHE-83b26c96-14

Cc1ccncc1NC(=O)Cc1cccc(C(F)(F)F)c1

3-aminopyridine-like Enamine Mcule Assayed View
Cc1ccncc1N(C)C(=O)Cc1cccc(Cl)c1

JAN-GHE-83b26c96-15

Cc1ccncc1N(C)C(=O)Cc1cccc(Cl)c1

3-aminopyridine-like Enamine Assayed View
CCCN(C(=O)Cc1cccc(Cl)c1)c1cccnc1

JAN-GHE-83b26c96-16

CCCN(C(=O)Cc1cccc(Cl)c1)c1cccnc1

3-aminopyridine-like Enamine Assayed View
Cc1ccncc1NS(=O)(=O)Cc1cccc(Cl)c1

JAN-GHE-83b26c96-17

Cc1ccncc1NS(=O)(=O)Cc1cccc(Cl)c1

Enamine Mcule Assayed View
O=C1NC(c2cccnc2)C(=O)N1c1cccc(Cl)c1

JAN-GHE-83b26c96-18

O=C1NC(c2cccnc2)C(=O)N1c1cccc(Cl)c1

3-aminopyridine-like Enamine Assayed View
O=C(Nc1cccnc1)Nc1cccc(Cl)c1

JAN-GHE-83b26c96-19
Duplicate of:
DAR-DIA-23aa0b97-14

O=C(Nc1cccnc1)Nc1cccc(Cl)c1

Duplicate 3-aminopyridine-like Enamine Mcule MolPort Assayed View
Cc1ccncc1NC(=O)C1(c2cccc(Cl)c2)CC1

JAN-GHE-83b26c96-20

Cc1ccncc1NC(=O)C1(c2cccc(Cl)c2)CC1

3-aminopyridine-like Enamine Assayed View
Cc1ccncc1NS(=O)(=O)c1cccc(Cl)c1

JAN-GHE-83b26c96-21

Cc1ccncc1NS(=O)(=O)c1cccc(Cl)c1

Enamine Mcule Assayed View
Cc1ccncc1NC(=O)C(C)(C)c1cccc(Cl)c1

JAN-GHE-83b26c96-22

Cc1ccncc1NC(=O)C(C)(C)c1cccc(Cl)c1

3-aminopyridine-like Enamine Mcule Assayed View
Cc1ccncc1NC(=O)C(F)(F)c1cccc(Cl)c1

JAN-GHE-83b26c96-23

Cc1ccncc1NC(=O)C(F)(F)c1cccc(Cl)c1

3-aminopyridine-like Assayed View
Cc1ccncc1-c1nnc(-c2cccc(Cl)c2)o1

JAN-GHE-83b26c96-24

Cc1ccncc1-c1nnc(-c2cccc(Cl)c2)o1

Assayed View
Cc1ccncc1-c1nc(-c2cccc(Cl)c2)no1

JAN-GHE-83b26c96-25

Cc1ccncc1-c1nc(-c2cccc(Cl)c2)no1

Enamine Assayed View

Design Rationale:

Library of Enamine REAL analogues of HIT compound TRY-UNI-714a760b-6 for SAR analysis.

Other Notes:

https://drug-hunter.com/2020/02/01/topliss/ useful charts for SAR

Inspired By:
Discussion: