Molecule Details

N#Cc1cccc(C2CN(C(=O)CCl)Cc3ccccc32)c1
Assayed
View on Fragalysis x10678
Molecular Properties
SMILES:
N#Cc1cccc(C2CN(C(=O)CCl)Cc3ccccc32)c1
MW: 310.784
Fraction sp3: 0.22
HBA: 2
HBD: 0
Rotatable Bonds: 2
TPSA: 44.1
cLogP: 3.27118
Covalent Warhead: ✔️
Covalent Fragment:
Activity Data
IC50 (µM) - Fluorescence: 1.17209011887828
IC50 (µM) - RapidFire: 1.44102015403721
Trypsin IC50 (µM): 99.0
pIC50 (µM) - Fluorescence 5.93103899529156
Average Inhibition @ 20 µM - Fluorescence: 98.75318
Average Inhibition @ 50 µM - Fluorescence: 95.349185
Average Inhibition @ 50 µM - RapidFire: 97.83
Relative Solubility @ 20 µM: 1.0
Relative Solubility @ 100 µM: 0.99
Order Status
Ordered: 2020-04-17
Synthesis Location: enamine
Shipped: 2020-06-24
CC(=O)NCCc1c[nH]c2ccc(F)cc12

AAR-POS-d2a4d1df-2

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CN1CCCc2ccc(S(N)(=O)=O)cc21

AAR-POS-d2a4d1df-4

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CCNc1ccc(C#N)cn1

AAR-POS-d2a4d1df-5

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NC(=O)[C@H]1CCC[C@H]1c1ccsc1

AAR-POS-d2a4d1df-14

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Cc1cccc(C2CN(C(=O)CCl)Cc3ccccc32)c1

NIR-THE-c331be7a-6
0.706

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O=C(CCl)N1Cc2ccccc2[C@H](c2cccc(F)c2)C1

DAR-DIA-caba39e3-1
0.681

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Nc1cccc(C2CN(C(=O)CCl)Cc3ccccc32)c1

NIR-THE-c331be7a-1
0.681

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O=C(CCl)N1Cc2ccccc2C(c2ccccc2)C1

AAR-POS-0daf6b7e-14
0.652

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COc1cccc([C@@H]2CN(C(=O)CCl)Cc3ccccc32)c1

DAR-DIA-caba39e3-2
0.644

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NC(=O)Cc1ccccc1C1CN(C(=O)CCl)Cc2ccccc21

NIR-THE-c331be7a-4
0.547

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NC(=O)Cc1ccccc1C1CN(C(=O)CCl)Cc2ccccc21

MIH-UNI-e573136b-9
0.547

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O=C(CCl)N1Cc2ccccc2C(c2cccc(CNC(=O)N3CCOCC3)c2)C1

TAM-UNI-d1c3dd9f-7
0.534

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NS(=O)(=O)c1ccc2ccc(C3CN(C(=O)CCl)Cc4ccccc43)cc2c1

MIH-UNI-e573136b-12
0.518

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NS(=O)(=O)c1ccc2ccc(C3CN(C(=O)CCl)Cc4ccccc43)cc2c1

NIR-THE-c331be7a-5
0.518

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NS(=O)(=O)C1CCc2ccc(C3CN(C(=O)CCl)Cc4ccccc43)cc2C1

DAV-CRI-3fe943ba-1
0.518

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NS(=O)(=O)c1ccc2ccc(C3CN(C(=O)CCl)Cc4ccccc43)cc2c1

TAM-UNI-d1c3dd9f-3
0.518

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NS(=O)(=O)C1CCc2cc(C3CN(C(=O)CCl)Cc4ccccc43)ccc2C1

DAV-CRI-3fe943ba-2
0.512

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O=C(CCl)N1CC2C(=CC=C2C2CN(C(=O)CCl)Cc3ccccc32)C(c2ccccc2)C1

JAR-IMP-ed466bb3-2
0.506

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CS(=O)(=O)N1CCc2ccc(C3CN(C(=O)CCl)Cc4ccccc43)cc2C1

TAM-UNI-d1c3dd9f-8
0.506

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CNS(=O)(=O)c1ccc(C#N)c(C2CN(C(=O)CCl)Cc3ccccc32)c1

TAM-UNI-d1c3dd9f-10
0.494

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O=C(CCl)N1Cc2ccccc2[C@H](c2cc(F)cc3ccccc23)C1

DAR-DIA-caba39e3-7
0.476

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O=C(CCl)N1Cc2ccccc2[C@H](c2cc(Cl)cc3ccccc23)C1

DAR-DIA-caba39e3-8
0.476

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COc1cc([C@@H]2CN(C(=O)CCl)Cc3ccccc32)c2ccccc2c1

DAR-DIA-caba39e3-9
0.471

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CC(=O)NCCCc1cn(C)c2cc(C3CN(C(=O)CCl)Cc4ccccc43)ccc12

TAM-UNI-d1c3dd9f-11
0.469

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N#Cc1cnc(CNC(=O)N2CCOCC2)c([C@@H]2CN(C(=O)CCl)Cc3ccccc32)c1

DAR-DIA-caba39e3-12
0.459

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O=C(CCl)N1Cc2ccccc2C(c2nc3ccccc3s2)C1

IND-SYN-6c8299e8-3
0.459

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O=C(CCl)N1Cc2cc(O)ccc2C(c2ccccc2)C1

MIH-UNI-e573136b-10
0.456

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O=C(CN1Cc2ccccc2C(c2ccccc2)C1)N1Cc2ccccc2C(c2ccccc2)C1

JAR-IMP-ed466bb3-8
0.450

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O=C(CCl)N1Cc2ccc(CO)cc2C(c2ccccc2)C1

THO-SYG-4e0386bb-1
0.444

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COc1cc([C@@H]2CN(C(=O)CCl)Cc3ccccc32)c2[nH]ccc2c1

DAR-DIA-caba39e3-3
0.440

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O=C(CCl)N1Cc2ccccc2C(C2CCCS2)C1

MIH-UNI-e573136b-11
0.415

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CS(=O)(=O)Nc1ccc2c(c1)C(c1ccccc1)CN(C(=O)CCl)C2

MIH-UNI-e573136b-15
0.414

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COc1cc([C@@H]2CN(C(=O)CCl)Cc3ccccc32)c2ccc(S(N)(=O)=O)cc2c1

DAR-DIA-caba39e3-10
0.412

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CN(C)C(=O)C=CC(=O)N1Cc2ccccc2[C@H](c2cccc(Cl)c2)C1

RAI-NOV-a7d52b4a-3
0.404

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O=C1NCCC1=CC(=O)N1Cc2ccccc2[C@H](c2cccc(Cl)c2)C1

RAI-NOV-a7d52b4a-1
0.402

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COc1cc([C@@H]2CN(C(=O)CCl)Cc3ccccc32)c2[nH]cc(CCNC(C)=O)c2c1

DAR-DIA-caba39e3-4
0.402

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CC(C)N(C)C(=O)c1ccc2c(c1)CN(C(=O)CCl)CC2c1ccccc1

SAL-INS-1c7a5a55-1
0.400

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O=C(c1cccc2ccccc12)N1Cc2ccccc2C(c2ccccc2)C1

JAR-IMP-ed466bb3-3
0.398

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O=C(CCl)N1Cc2ccccc2C(c2cccc(NCc3cc(-c4ccccc4F)n(S(=O)(=O)c4cccnc4)c3)c2)C1

MAK-UNK-702fb7d3-13
0.395

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Cc1ccncc1N1C(=O)C(c2cccc(C#N)c2)CN1C(=O)CCl

MIC-UNK-e8a42ca9-2
0.394

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O=C(CCl)N1Cc2ccccc2[C@H](c2cc(F)cnc2CNC(=O)N2CCOCC2)C1

DAR-DIA-caba39e3-13
0.392

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COc1cc([C@@H]2CN(C(=O)CCl)Cc3ccccc32)c2ccc(CCNC(C)=O)cc2c1

DAR-DIA-caba39e3-11
0.388

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CC(=O)NCCc1c[nH]c2c([C@@H]3CN(C(=O)CCl)Cc4ccccc43)cc(Cl)cc12

DAR-DIA-caba39e3-5
0.386

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CC(=O)NCCc1c[nH]c2c([C@@H]3CN(C(=O)CCl)Cc4ccccc43)cc(F)cc12

DAR-DIA-caba39e3-6
0.386

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O=C(Nc1cc2cc(C(=O)O)cnc2[nH]1)Nc1cc(O)ccc1C1CN(C(=O)CCl)Cc2ccccc21

JAN-LUN-04aedcc0-6
0.382

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Cc1ccncc1N1C(=O)C(c2cccc(C#N)c2)CCN1C(=O)CCl

MIC-UNK-e8a42ca9-1
0.381

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O=C(CCl)N1Cc2cc3c([N+](=O)[O-])cccc3cc2C(c2ccccc2)C1

SAL-INS-1c7a5a55-5
0.380

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CN(C)C/C=C/C(=O)N1Cc2ccccc2C(c2ccccc2)C1

REN-UFA-aaaed2d6-1
0.379

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C=C(CN(C)C)C(=O)N1Cc2ccccc2C(c2ccccc2)C1

REN-UFA-aaaed2d6-3
0.376

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CC(=O)NCCc1c[nH]c2c(C3CN(C(=O)CCl)Cc4ccccc43)c(F)ccc12

NIR-THE-c331be7a-3
0.375

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C=C(CCN(C)C)C(=O)N1Cc2ccccc2C(c2ccccc2)C1

REN-UFA-aaaed2d6-2
0.368

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CNCCN(C)C(=O)C(=O)N1Cc2ccccc2C(c2ccccc2)C1

REN-UFA-aaaed2d6-5
0.367

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CN(CCC(N)=O)C(=O)C(=O)N1Cc2ccccc2C(c2ccccc2)C1

REN-UFA-aaaed2d6-6
0.367

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O=C(Nc1ccccc1O)C1CCN(C(=O)CCC(=O)N2Cc3ccccc3C(c3ccccc3)C2)CC1

JAR-IMP-ed466bb3-12
0.366

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N#Cc1cccc(CC2CCN(C(=O)CCl)CC2)c1

MAK-UNK-10dfa458-40
0.366

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CN(C(=O)c1ccc2c(c1)CN(C(=O)CCl)CC2c1ccccc1)c1c[nH]cn1

SAL-INS-1c7a5a55-2
0.364

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N#Cc1cccc(CN2CCN(C(=O)CCl)CC2)c1

MAT-POS-ee51dedd-1
0.362

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O=C1NCCC1=CC(=O)N1Cc2ccccc2[C@H](c2ccccc2)C1

RAI-NOV-a7d52b4a-2
0.360

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N#Cc1conc1C1CN(C(=O)CCl)Cc2cc(CO)ccc21

THO-SYG-4e0386bb-3
0.358

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NS(=O)(=O)c1ccc(C(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

JAR-IMP-ed466bb3-13
0.352

View
O=C(CCl)N1Cc2ccccc2C(c2ccc(NCc3cc(-c4ccccc4F)n(S(=O)(=O)c4cccnc4)c3)cc2)C1

MAK-UNK-702fb7d3-14
0.350

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N#Cc1cccc(C(c2ccccc2)N2CCN(C(=O)CCl)CC2)c1

DAR-DIA-3e9bbd81-11
0.349

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N#Cc1cccc(NC2CCN(C(=O)CCl)C2)c1

TAT-ENA-80bfd3e5-10
0.349

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N#Cc1conc1C1CN(C(=O)CCl)Cc2ccc(CO)cc21

THO-SYG-4e0386bb-2
0.347

View
N#CC(=CC(=O)N1Cc2ccccc2[C@H](c2ccccc2)C1)c1cc[nH]n1

RAI-NOV-a7d52b4a-5
0.347

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NS(=O)(=O)c1ccc2c(c1)N(CC(=O)N1Cc3ccccc3C(c3ccccc3)C1)CCC2

JAR-IMP-ed466bb3-6
0.346

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N#Cc1cccc(C23CC(c4ccccc42)N(C(=O)CCl)C3)c1

MAK-UNK-ec98eaf6-40
0.344

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N#Cc1cccc(C(CCc2ccccc2)N2CCN(C(=O)CCl)CC2)c1

PAU-WEI-b9b69149-4
0.344

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CC1CN(C(=O)N2Cc3ccccc3C(c3ccccc3)C2)CCO1

JAR-IMP-ed466bb3-7
0.341

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C=CC(=O)N1CCC(C(=O)N2Cc3ccccc3C(c3ccccc3)C2)CC1

SAD-SAT-1f400d17-9
0.341

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N#CC(=CC(=O)N1Cc2ccccc2[C@H](c2ccccc2)C1)c1cscn1

RAI-NOV-a7d52b4a-4
0.340

View
O=C(N1Cc2ccccc2[C@H](c2ccccc2)C1)[C@]1(F)CCCOC1

RAI-NOV-2f6a9876-6
0.337

View
O=C(/C=C/Cn1cncn1)N1Cc2ccccc2C(c2ccccc2)C1

REN-UFA-aaaed2d6-4
0.337

View
CC(=O)NCCc1c[nH]c2c(C3CN(C(C)=O)Cc4ccccc43)cc(C#N)cc12

JOH-MSK-2d8052dc-1
0.337

View
Cc1ccc(CCC(c2cccc(C#N)c2)N2CCN(C(=O)CCl)CC2)cc1

PAU-WEI-b9b69149-6
0.333

View
O=C(CCl)N1Cc2c(OCCN3CCOCC3)cccc2[C@H](c2cccc(Cl)c2)C1

SEA-TRI-fac72a44-1
0.330

View
O=C(C(=O)N1Cc2ccccc2C(c2ccccc2)C1)N1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1

JAR-IMP-ed466bb3-4
0.327

View
CC(C)N(C)C(=O)c1ccc2c(c1)CN(C(=O)CCl)CC2c1c[nH]cn1

SAL-INS-1c7a5a55-3
0.327

View
O=C(CCl)N1Cc2ccccc2C(c2ccccc2NCc2cc(-c3ccccc3F)n(S(=O)(=O)c3cccnc3)c2)C1

MAK-UNK-702fb7d3-12
0.325

View
CN(C(=O)c1ccc2c(c1)CN(C(=O)CCl)CC2c1c[nH]cn1)c1c[nH]cn1

SAL-INS-1c7a5a55-4
0.320

View
O=C(CCl)N1Cc2cc3c([N+](=O)[O-])cccc3cc2C(c2c[nH]cn2)C1

SAL-INS-1c7a5a55-6
0.317

View
CC(C)C[C@@H]1CN(C(=O)CCl)CCN1Cc1cccc(C#N)c1

SAD-SAT-c989feaa-2
0.316

View
N#Cc1cccc(C(c2ccccc2)N2CC3CC2CN3C(=O)CCl)c1

DAR-DIA-3e9bbd81-7
0.316

View
CN(CC(=O)N1Cc2ccccc2C(c2ccccc2)C1)Cc1cc(-c2ccccc2F)n(S(=O)(=O)c2cccnc2)c1

MAK-UNK-702fb7d3-17
0.314

View
N#Cc1cccc(CCc2ccnc(C3CCCN(C(=O)CCl)C3)c2)c1

WAR-XCH-bdd24732-19
0.310

View
N#Cc1cccc(C(CCc2ccc(C(F)(F)F)cc2)N2CCN(C(=O)CCl)CC2)c1

PAU-WEI-b9b69149-5
0.310

View
O=C(CCNCc1cc(-c2ccccc2F)n(S(=O)(=O)c2cccnc2)c1)N1Cc2ccccc2C(c2ccccc2)C1

MAK-UNK-702fb7d3-1
0.309

View
N#Cc1ccc(C(=O)N2CCN(C(=O)CCl)CC2)cc1

MAK-UNK-987948f6-3
0.308

View
N#Cc1ccc(CN2CCN(C(=O)CCl)CC2)cc1

MAK-UNK-6ca90168-14
0.308

View
O=C(O)CCCc1cncc(NC(=O)Nc2cc(O)ccc2C2CN(C(=O)CCl)Cc3ccc(O)cc32)c1

JAN-LUN-04aedcc0-7
0.307

View
N#Cc1cccc(CC2CC3CCC(C2)N3C(=O)CCl)c1

MAK-UNK-10dfa458-41
0.307

View
C=CC(=O)N1Cc2ccccc2C(c2cccc(C#N)c2)C1C(=O)Nc1cnccc1C

TRY-UNI-9f475305-12
0.306

View
O=C(CCl)N1Cc2ccccc2C(c2ccccc2)C1C#Cc1cccnc1

DAV-CRI-1c77f7a9-3
0.303

View
O=C(CCl)N1Cc2ccccc2C(c2cccc(Cl)c2)C1Cc1cccnc1

DAV-CRI-1c77f7a9-4
0.301

View
N#Cc1cccc(C(N2CCN(C(=O)CCl)CC2)n2ccc3ccccc32)c1

DAR-DIA-3e9bbd81-16
0.300

View
N#Cc1cccc(NC(=O)N(CC2CC2)c2cc(F)c(N3CCN(C(=O)CCl)CC3)c(F)c2)c1

NIM-UNI-310206f0-35
0.299

View
CC(=O)N1Cc2ccccc2C(c2cc3[nH]cc(C4CC4)c3cc2Cl)C1

DOU-UNK-b5326f8f-14
0.299

View
O=C(CCl)N1Cc2cc(NCc3cc(-c4ccccc4F)n(S(=O)(=O)c4cccnc4)c3)ccc2C(c2ccccc2)C1

MAK-UNK-702fb7d3-9
0.298

View
O=C(CCl)N1Cc2ccccc2C(c2ccccc2)C1Cc1cccnc1

DAV-CRI-1c77f7a9-1
0.296

View
N#Cc1cccc(C(CCc2ccccc2)N2CC3CC2CN3C(=O)CCl)c1

MAK-UNK-ec98eaf6-51
0.294

View
N#Cc1cc(CN2CCN(C(=O)CCl)CC2)c2ccccc2c1

DAR-DIA-fb20be43-6
0.293

View
N#Cc1cccc(N2CCN(C(=O)CCl)C(c3cccnc3)C2=O)c1

MIC-UNK-df342a3f-1
0.293

View
CN1CCCc2ccc(S(=O)(=O)C(=O)N3Cc4ccccc4C(c4ccccc4)C3)cc21

JAR-IMP-ed466bb3-1
0.292

View
O=C(Nc1cc2cc(C(=O)O)cnc2[nH]1)Nc1cc(O)ccc1C1CN(C(=O)CCl)Cc2ccc(O)cc21

JAN-LUN-04aedcc0-5
0.291

View
O=C(CCl)N1Cc2ccccc2C(c2ccccc2)C1

0.689

View
N#Cc1cccc(OCC(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.655

View
N#Cc1cccc(C(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.647

View
N#Cc1cccc(S(=O)(=O)NCC(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.632

View
N#Cc1cccc(NC(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.611

View
N#Cc1cccc(C2(C(=O)N3Cc4ccccc4C(c4ccccc4)C3)CC2)c1

0.607

View
N#Cc1ccc(CC(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.604

View
N#Cc1ccc(OCC(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.600

View
N#Cc1cccc(CNC(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.596

View
N#Cc1ccc(OCC(=O)N2Cc3ccccc3C(c3ccccc3)C2)c(Cl)c1

0.593

View
N#Cc1cccc(NC(=O)C(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.589

View
N#Cc1ccc(CCC(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.582

View
N#CCC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.580

View
N#Cc1ccc(S(=O)(=O)NCC(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.579

View
N#Cc1cccc(C(=O)NNC(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.579

View
N#Cc1cccc(CNC(=O)C(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.576

View
N#Cc1ccc(SCC(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.571

View
N#Cc1ccc(NCC(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.571

View
N#CCCCC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.566

View
N#Cc1ccc(C(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.558

View
COc1cc(C#N)ccc1OCC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.557

View
N#Cc1cccc(CCNC(=O)C(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.557

View
N#CCCCCC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.556

View
N#Cc1ccc(CSCC(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.552

View
N#Cc1ccc(CS(=O)(=O)CC(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.552

View
N#Cc1ccc(C(=O)NCC(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.552

View
N#Cc1cnn(CC(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.552

View
CC1CN(C(=O)CCl)Cc2ccccc21

0.551

View
CC(NC(=O)N1Cc2ccccc2C(c2ccccc2)C1)c1cccc(C#N)c1

0.550

View
CC(Oc1cccc(C#N)c1)C(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.550

View
N#CCCCCCC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.545

View
N#Cc1c[nH]c(C(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.545

View
CC1CN(C(=O)COc2cccc(C#N)c2)Cc2ccccc21

0.542

View
N#Cc1cccc(-n2ccc(C(=O)N3Cc4ccccc4C(c4ccccc4)C3)n2)c1

0.541

View
CC1CN(C(=O)CNS(=O)(=O)c2cccc(C#N)c2)Cc2ccccc21

0.541

View
N#Cc1csc(C(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.536

View
CC(NC(=O)C(=O)N1Cc2ccccc2C(c2ccccc2)C1)c1cccc(C#N)c1

0.532

View
O=C(CC1CC1(Cl)Cl)N1Cc2ccccc2C(c2ccccc2)C1

0.528

View
N#CCSCC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.527

View
CC(C)(C#N)CC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.527

View
CC1CN(C(=O)c2cccc(C#N)c2)Cc2ccccc21

0.527

View
N#CC1(CC(=O)N2Cc3ccccc3C(c3ccccc3)C2)CC1

0.527

View
N#Cc1ccccc1OCC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.526

View
N#Cc1cc(O)cc(C(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.526

View
N#Cc1ncn(CC(=O)N2Cc3ccccc3C(c3ccccc3)C2)n1

0.525

View
CC1CN(C(=O)[C@@H]2C[C@H]2c2cccc(C#N)c2)Cc2ccccc21

0.525

View
N#Cc1cccc(CNC(=O)CN2Cc3ccccc3C(c3ccccc3)C2)c1

0.525

View
N#Cc1cccc(C(=O)NNC(=O)CN2Cc3ccccc3C(c3ccccc3)C2)c1

0.525

View
COc1cc(C#N)ccc1OCCCC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.523

View
CCC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.520

View
NCC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.520

View
N#CCc1ccccc1CC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.518

View
N#Cc1cccc(S(=O)(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.518

View
N#Cc1ccc(NC(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.518

View
N#Cc1cc(C(=O)N2Cc3ccccc3C(c3ccccc3)C2)c[nH]1

0.518

View
N#Cc1ccc(CNC(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.517

View
N#Cc1ccc(NC(=O)C(=O)N2Cc3ccccc3C(c3ccccc3)C2)c(F)c1

0.517

View
N#Cc1cccc(NC(=O)CCN2Cc3ccccc3C(c3ccccc3)C2)c1

0.516

View
N#Cc1ccc(F)c(CNC(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.516

View
CC(NS(=O)(=O)c1cccc(C#N)c1)C(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.516

View
O=C(COc1ccccc1)N1Cc2ccccc2C(c2ccccc2)C1

0.509

View
O=C(CN1CCCC1)N1Cc2ccccc2C(c2ccccc2)C1

0.509

View
N#Cc1cccc([C@@H]2C[C@H]2C(=O)N2Cc3ccccc3C2)c1

0.509

View
N#Cc1ccc(C(=O)N2Cc3ccccc3C(c3ccccc3)C2)[nH]1

0.509

View
N#Cc1ccc(C(=O)N2Cc3ccccc3C(c3ccccc3)C2)nc1

0.509

View
CC1CN(C(=O)Nc2cccc(C#N)c2)Cc2ccccc21

0.509

View
N#Cc1ccc(NC(=O)C(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.509

View
N#Cc1cccc(C(=O)N2Cc3ccccc3C(C(=O)O)C2)c1

0.509

View
N#Cc1ccc(CC(C#N)C(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.508

View
CC1CN(C(=O)C2(c3cccc(C#N)c3)CC2)Cc2ccccc21

0.508

View
N#Cc1cccc(CS(=O)(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.508

View
Cc1ccc(C#N)cc1NC(=O)C(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.508

View
N#Cc1cccc([C@@H]2C[C@H]2C(=O)N2Cc3ccccc3C(C(=O)O)C2)c1

0.508

View
COC(=O)C1CN(C(=O)COc2cccc(C#N)c2)Cc2ccccc21

0.508

View
CCCC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.500

View
O=C(Cc1cccc(F)c1)N1Cc2ccccc2C(c2ccccc2)C1

0.500

View
C#CCCC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.500

View
N#CC1(C(=O)N2Cc3ccccc3C(c3ccccc3)C2)CC1

0.500

View
O=C(CC1CC1)N1Cc2ccccc2C(c2ccccc2)C1

0.500

View
N#CCc1cccc(C(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.500

View
N#CCOc1ccc(CC(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.500

View
N#Cc1ccc(C2CC2C(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.500

View
Cc1cc(C#N)cnc1C(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.500

View
N#Cc1ccc(C=CC(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.500

View
CC1CN(C(=O)COc2ccc(C#N)cc2)Cc2ccccc21

0.500

View
CC1CN(C(=O)CCCCOc2cccc(C#N)c2)Cc2ccccc21

0.500

View
O=C(CCO)N1Cc2ccccc2C(c2ccccc2)C1

0.500

View
N#Cc1ccc(C(=O)NNC(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.500

View
CC(C#N)C(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.500

View
O=C(CCC(F)F)N1Cc2ccccc2C(c2ccccc2)C1

0.500

View
COc1cccc(OC)c1CC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.500

View
N#CCOc1cccc(CC(=O)N2Cc3ccccc3C(c3ccccc3)C2)c1

0.500

View
NCCC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.500

View
O=C(CNC1CC1)N1Cc2ccccc2C(c2ccccc2)C1

0.500

View
CC(C)(C)CCC(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.500

View
N#Cc1cccc(OC2CCN(C(=O)CCl)CC2)c1

0.500

View
COC(=O)C1CN(C(=O)CCl)Cc2ccccc21

0.500

View
N#Cc1ccc(CNC(=O)C(=O)N2Cc3ccccc3C(c3ccccc3)C2)cc1

0.500

View
CCOc1ccc(C#N)cc1NC(=O)C(=O)N1Cc2ccccc2C(c2ccccc2)C1

0.492

View
CC1CN(C(=O)COc2ccc(C#N)cc2Cl)Cc2ccccc21

0.492

View

C(N1CC2=CC(C)=CC=C2CC1)(=O)C(C1=CC=CC=C1)C1=CC=CC=C1

0.766

View
C(N1CCC2=C(C=CC=C2)C1)(C(C1=CC=CC=C1)C1=CC=CC=C1)=O

0.757

View
C(N1CCC2=C(C=CC=C2)C1)(=O)C(C1=CC=C(C)C=C1)C1=CC=CC=C1

0.750

View
C(N1CC2=C(C=CC=C2)C(C)(C)C1)(=O)CC1C=CC=C(C)C=1

0.746

View
C(N1CC2=C(C=CC=C2)C(C)(C)C1)(=O)C(C1=CC=CC=C1)C1=CC=CC=C1

0.738

View


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