Molecule Details

COc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2ccccc12
quinolones Enamine Assayed
View on Fragalysis x10419
Molecular Properties
SMILES:
COc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2ccccc12
MW: 352.14
Fraction sp3: 0.2
HBA: 4
HBD: 1
Rotatable Bonds: 6
TPSA: 71.63
cLogP: 2.69
Covalent Warhead:
Covalent Fragment:
Source
Enamine Extended REAL: s_22____1055218____59160
Activity Data
Average Inhibition @ 20 µM - Fluorescence: 12.1322165
Average Inhibition @ 50 µM - Fluorescence: 12.50561
Relative Solubility @ 20 µM: 0.99
Relative Solubility @ 100 µM: 0.98
Order Status
Ordered: 2020-05-17
Synthesis Location: enamine
Shipped: 2020-06-10
CS(=O)(=O)NCCc1ccccc1

AAR-POS-d2a4d1df-1

View

COc1ccc(Cl)cc1OCCN(C)C(=O)c1cc(=O)[nH]c2ccccc12

BEN-DND-b89db3f2-5
0.734

View
COc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2cc(F)ccc12

MAT-POS-590ac91e-37
0.696

View
COc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2ccc(Cl)cc12

MAT-POS-590ac91e-43
0.688

View
COc1ccccc1OCCN(C(=O)c1cc(=O)[nH]c2ccccc12)c1cccc(Cl)c1

ALP-POS-fc6c627f-3
0.625

View
COc1ccccc1OCCNC(=O)c1cc(=O)[nH]c2ccccc12

MAT-POS-916a2c5a-2
0.605

View
COc1ccccc1OCC(CC(C)C)NC(=O)c1cc(=O)[nH]c2ccccc12

DAR-DIA-8e329c92-6
0.506

View
COc1ccccc1OCC(NC(=O)c1cc(=O)[nH]c2ccccc12)C1CC1

DAR-DIA-8e329c92-4
0.500

View
COc1ccccc1OCC(NC(=O)c1cc(=O)[nH]c2ccccc12)N1CCC1

DAR-DIA-8e329c92-5
0.495

View
COc1ccccc1OCCC(=O)Nc1cc(=O)[nH]c2ccccc12

MAR-UCB-f313ec4d-1
0.494

View
COc1ccccc1OCC(NC(=O)c1cc(=O)[nH]c2ccccc12)N1CCCCC1

DAR-DIA-8e329c92-7
0.474

View
COc1ccccc1O[C@H]1CC[C@@H]1NC(=O)c1cc(=O)[nH]c2ccccc12

MAT-UCB-70f7c0f7-4
0.467

View
COc1ccc(Cl)cc1OCCNC(=O)c1cc(=O)[nH]c2ccccc12

ALP-POS-05819dc4-1
0.447

View
COc1ccccc1OC1CN(C(=O)c2cc(=O)[nH]c3ccccc23)C1

ERI-UCB-a0b0dbcb-9
0.444

View
COc1ccccc1NCCNC(=O)c1cc(=O)[nH]c2ccccc12

MAR-UCB-f313ec4d-4
0.440

View
COc1ccccc1OCC(CN1CCOCC1)NC(=O)c1cc(=O)[nH]c2ccccc12

DAR-DIA-8e329c92-8
0.437

View
COc1ccccc1OCCNC(=O)c1cc(=O)[nH]c2ccc(Cl)cc12

MAT-POS-590ac91e-42
0.436

View
COc1c(Cl)cccc1OCCNC(=O)c1cc(=O)[nH]c2ccccc12

ALP-POS-3fc1724e-1
0.432

View
COc1ccccc1O[C@H]1CCCC[C@H]1NC(=O)c1cc(=O)[nH]c2ccccc12

ADA-UCB-b1b30a00-2
0.427

View
COc1ccccc1O[C@H]1CCC[C@@H]1NC(=O)c1cc(=O)[nH]c2ccccc12

MAT-UCB-70f7c0f7-3
0.427

View
COc1ccccc1OCCNC(=O)c1cc(=O)[nH]c2cc(F)ccc12

MAT-POS-590ac91e-32
0.426

View
COc1ccccc1OCCNC(=O)c1cc(=O)[nH]c2cccc(OC)c12

EDJ-MED-6af13d92-3
0.424

View
COc1ccccc1OC1CCN(C(=O)c2cc(=O)[nH]c3ccccc23)C1

ERI-UCB-a0b0dbcb-6
0.417

View
COc1ccccc1N1CCN(C(=O)c2cc(=O)[nH]c3ccccc23)CC1

BEN-DND-7e92b6ca-13
0.413

View
O=C(COc1cccc(Cl)c1)N(C(=O)c1cc(=O)[nH]c2ccccc12)C1CC1

JAN-GHE-82a280f8-3
0.412

View
COc1ccccc1OCCNC(=O)c1cc(=O)[nH]c2cccc(C)c12

EDJ-MED-6af13d92-1
0.411

View
COc1ccccc1OCCNC(=O)c1cc(=O)[nH]c2cccc(F)c12

EDJ-MED-6af13d92-2
0.411

View
O=C(NCCOc1ccccc1)c1cc(=O)[nH]c2ccccc12

BEN-DND-7e92b6ca-5
0.398

View
CN(CCNC(=O)c1cc(=O)[nH]c2ccccc12)c1ccccc1

BEN-DND-7e92b6ca-3
0.396

View
COc1ccccc1NC1CN(C(=O)c2cc(=O)[nH]c3ccccc23)C1

ERI-UCB-a0b0dbcb-8
0.392

View
COc1ccccc1OCCNC(=O)c1c(C#N)c(=O)[nH]c2ccccc12

ERI-UCB-ce40166b-25
0.392

View
COc1cccc(CCN(C(=O)c2cc(=O)[nH]c3ccccc23)c2cccc(Cl)c2)c1

ALP-POS-ddb41b15-4
0.390

View
COc1cccc(NCNC(=O)c2cc(=O)[nH]c3ccccc23)c1

DAR-DIA-8e329c92-10
0.389

View
COc1ccccc1OCC(C)NC(=O)c1cc(=O)[nH]c2ccc(F)cc12

MAT-POS-590ac91e-41
0.388

View
COc1ccccc1NC1CCN(C(=O)c2cc(=O)[nH]c3ccccc23)C1

ERI-UCB-a0b0dbcb-5
0.386

View
O=C(NCCOc1cccc2c1CCCC2)c1cc(=O)[nH]c2ccccc12

MAT-UCB-70f7c0f7-1
0.382

View
COc1ccccc1OCC(C)NC(=O)c1cc(=O)[nH]c2cc(F)ccc12

MAT-POS-590ac91e-40
0.374

View
COc1ccccc1OC[C@H](C(=O)Nc1cc(=O)[nH]c2ccccc12)c1cccc(Cl)c1

ADA-UCB-6c2cb422-8
0.371

View
O=C(CCc1cccc(Cl)c1)N(C(=O)c1cc(=O)[nH]c2ccccc12)C1CC1

JAN-GHE-82a280f8-2
0.370

View
CN(C)c1cncc(CN(C(=O)c2cc(=O)[nH]c3ccccc23)c2cccc(Cl)c2)c1

ALP-POS-ddb41b15-3
0.362

View
COc1cccc(CN2CCN(C(=O)c3cc(=O)[nH]c4ccccc34)CC2)c1

ERI-UCB-a0b0dbcb-11
0.356

View
O=C(NCCNc1ccccc1)c1cc(=O)[nH]c2ccccc12

BEN-DND-7e92b6ca-4
0.356

View
COc1ccc(N2CCN(C(=O)c3cc(=O)[nH]c4ccccc34)CC2)cc1

BEN-DND-7e92b6ca-11
0.354

View
COc1ccc(N2CCN(C(=O)c3cc(=O)[nH]c4ccccc34)CC2)cc1

KRI-MAR-d2e3ef86-13
0.354

View
O=C(NCCOc1cccc(Oc2cccc(=O)[nH]2)c1)c1cc(=O)[nH]c2ccccc12

ERI-UCB-ce40166b-15
0.352

View
COc1ccccc1OCCNC(=O)c1cc[nH]c(=O)c1

BEN-DND-7e92b6ca-1
0.352

View
O=C(NCCOc1cccc2c1OCCC2)c1cc(=O)[nH]c2ccccc12

MAT-UCB-70f7c0f7-2
0.352

View
O=C1CCC(Oc2cccc(OCCNC(=O)c3cc(=O)[nH]c4ccccc34)c2)N1

ERI-UCB-ce40166b-14
0.349

View
COc1ccccc1OCCNC(=O)c1cc(O)cc2ccccc12

DAR-DIA-8e329c92-3
0.347

View
COc1ccccc1OCCNC(=O)c1cncc2ccccc12

MAR-UCB-f313ec4d-2
0.347

View
COc1cccc(N2CCN(C(=O)c3cc(=O)[nH]c4ccccc34)CC2)c1

MAR-UCB-f313ec4d-5
0.347

View
COc1cccc(N2CCN(C(=O)c3cc(=O)[nH]c4ccccc34)CC2)c1

BEN-DND-7e92b6ca-12
0.347

View
COc1cccc(N2CC3(CN(C(=O)c4cc(=O)[nH]c5ccccc45)C3)C2)c1

ERI-UCB-a0b0dbcb-1
0.347

View
COc1cc(Cl)cc(CN2CCN(C(=O)c3cc(=O)[nH]c4ccccc34)CC2)c1F

ALP-POS-3fc1724e-4
0.346

View
COc1ccccc1OCCNC(=O)c1cc(N)cc2ccccc12

DAR-DIA-8e329c92-2
0.344

View
Cn1c(=O)n(CCNC(=O)c2cc(=O)[nH]c3ccccc23)c2ccccc21

ADA-UCB-b1b30a00-1
0.343

View
CN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2cc(F)ccc12

MAT-POS-590ac91e-34
0.340

View
O=C1CC(Oc2cccc(OCCNC(=O)c3cc(=O)[nH]c4ccccc34)c2)N1

ERI-UCB-ce40166b-13
0.340

View
O=C1C(=O)N(C(=O)c2cc(=O)[nH]c3ccccc23)c2ccccc21

DAR-DIA-53551c05-22
0.337

View
O=C(NCCOc1cccc(Oc2cccnc2)c1)c1cc(=O)[nH]c2ccccc12

ERI-UCB-ce40166b-16
0.336

View
Cc1ccncc1NC(=O)N(C(=O)c1cc(=O)[nH]c2ccccc12)c1cc(Cl)cc(N(C)C)c1

ALP-POS-ddb41b15-10
0.336

View
O=C(c1ccccc1)N1CCN(C(=O)c2cc(=O)[nH]c3ccccc23)CC1

BEN-DND-7e92b6ca-6
0.333

View
O=C(NCCc1cccc2ccccc12)c1cc(=O)[nH]c2ccccc12

DAR-DIA-8e329c92-9
0.333

View
COc1ccccc1OC(C)CNC(=O)c1cc(=O)[nH]c2ccc(F)cc12

MAT-POS-590ac91e-39
0.333

View
CN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2ccc(F)cc12

MAT-POS-590ac91e-33
0.330

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(c2ccc(F)cc2)CC1

BEN-DND-7e92b6ca-14
0.330

View
Cc1ccncc1NC(=O)N(C(=O)c1cc(=O)[nH]c2ccccc12)c1cccc(Cl)c1

ALP-POS-ddb41b15-2
0.327

View
O=C1CN(c2cccc(Cl)c2)CCN1C(=O)c1cc(=O)[nH]c2ccccc12

JAN-GHE-82a280f8-1
0.327

View
COc1ccccc1OCCNC(=O)c1cc(N)nc2ccccc12

DAR-DIA-8e329c92-1
0.327

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(Cc2ccccc2)CC1

BEN-DND-7e92b6ca-10
0.326

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(Cc2ccccc2)CC1

KRI-MAR-d2e3ef86-5
0.326

View
COc1ccccc1OCCC(=O)Nc1cncc2ccccc12

MAR-UCB-f313ec4d-3
0.326

View
O=C1CCC(Oc2cc(Cl)cc(OCCNC(=O)c3cc(=O)[nH]c4ccccc34)c2)N1

ERI-UCB-ce40166b-18
0.324

View
COc1ccc(Cl)cc1CC(=O)Nc1cc(=O)[nH]c2ccccc12

MAT-POS-3b92565d-4
0.323

View
CN1CCN(c2ccc(NC(=O)c3cc(=O)[nH]c4ccccc34)cc2)CC1

KRI-MAR-d2e3ef86-15
0.323

View
COc1ccc(Cl)cc1CC(=O)Nc1cc(=O)[nH]c2ccccc12

MAT-POS-e1b5ac6b-2
0.323

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(c2ccccc2)CC1

MAT-POS-916a2c5a-4
0.323

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(c2ccccc2)CC1

EDJ-MED-78f964c8-1
0.323

View
O=C1CC(Oc2cc(Cl)cc(OCCNC(=O)c3cc(=O)[nH]c4ccccc34)c2)N1

ALP-POS-3fc1724e-2
0.321

View
O=C1CC(Oc2cc(Cl)cc(OCCNC(=O)c3cc(=O)[nH]c4ccccc34)c2)N1

ERI-UCB-ce40166b-17
0.321

View
COc1ccccc1OC(C)CNC(=O)c1cc(=O)[nH]c2cc(F)ccc12

MAT-POS-590ac91e-38
0.320

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(Cc2cccc(Cl)c2)CC1

ERI-UCB-a0b0dbcb-12
0.317

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(c2cccc(Cl)c2)CC1

ERI-UCB-a0b0dbcb-2
0.316

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CC2CC1CN2c1ccccc1

MAK-UNK-df1a028e-3
0.316

View
O=C1C(=O)N(C(=O)c2cc(=O)[nH]c3ccccc23)c2cc(Br)ccc21

DAR-DIA-53551c05-20
0.316

View
COc1ccccc1CO[C@H](C(=O)Nc1cc(=O)[nH]c2ccccc12)c1cccc(Cl)c1

ADA-UCB-6c2cb422-11
0.315

View
O=C(NCCOc1cc(Cl)cc(Oc2cccc(=O)[nH]2)c1)c1cc(=O)[nH]c2ccccc12

ERI-UCB-ce40166b-19
0.315

View
N#Cc1cccc(CN2CCN(C(=O)c3cc(=O)[nH]c4ccccc34)CC2)c1

ERI-UCB-a0b0dbcb-14
0.314

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(c2cccc(F)c2)CC1

BEN-DND-7e92b6ca-15
0.313

View
O=C(Nc1ccccc1N1CCCCC1)c1cc(=O)[nH]c2ccccc12

KRI-MAR-d2e3ef86-12
0.313

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(c2ccccc2F)CC1

BEN-DND-7e92b6ca-16
0.312

View
O=C(NCCOc1cc(Cl)cc(Oc2cccnc2)c1)c1cc(=O)[nH]c2ccccc12

ERI-UCB-ce40166b-20
0.312

View
NS(=O)(=O)c1ccc(CCNC(=O)c2cc(=O)[nH]c3ccccc23)c2ccccc12

DAR-DIA-8e329c92-11
0.311

View
Cc1cccc(N2CCN(C(=O)c3cc(=O)[nH]c4ccccc34)CC2)c1C

KRI-MAR-d2e3ef86-7
0.310

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CCn2ccnc2C1

BEN-DND-7e92b6ca-9
0.310

View
COc1cc(Cl)cc(CC(=O)Nc2cc(=O)[nH]c3ccccc23)c1

MAT-POS-3b92565d-5
0.310

View
N#Cc1cccc(N2CCN(C(=O)c3cc(=O)[nH]c4ccccc34)CC2)c1

ERI-UCB-a0b0dbcb-3
0.307

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(Cc2ccccc2F)CC1

ALP-POS-3fc1724e-3
0.307

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(S(=O)(=O)c2ccccc2)CC1

BEN-DND-7e92b6ca-7
0.306

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(Cc2cccc(C(F)(F)F)c2)CC1

ERI-UCB-a0b0dbcb-13
0.305

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(c2cccc(C(F)(F)F)c2)CC1

ERI-UCB-a0b0dbcb-4
0.304

View
COc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2ccc(F)cc12

0.808

View
COc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2cc(F)ccc12

0.808

View
COc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2ccc([N+](=O)[O-])cc12

0.750

View
COc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2c(Br)cccc12

0.727

View
COc1ccccc1OCCN(C)C(=O)c1c[nH]c2ccccc2c1=O

0.712

View
COc1ccccc1OCCN(C)C(=O)c1cccc2c(=O)c3ccccc3[nH]c12

0.704

View
COc1ccccc1OCCN(C)C(=O)c1cc(=O)n(C)c2ccccc12

0.698

View
COc1ccccc1OCCN(C)C(=O)c1cccc2[nH]ccc12

0.679

View
CN(CCOc1ccccc1Cl)C(=O)c1cc(=O)[nH]c2cc(F)ccc12

0.667

View
CN(CCOc1ccccc1Cl)C(=O)c1cc(=O)[nH]c2ccc(F)cc12

0.667

View
COc1ccccc1OCCN(C)C(=O)c1cccc2ccccc12

0.667

View
COc1ccccc1OCCN(C)C(=O)c1cc(Br)cc2ccccc12

0.667

View
COc1ccccc1OCCN(C)C(=O)c1cc2ccccc2[nH]c1=O

0.667

View
CN(CCOc1ccccc1F)C(=O)c1cc(=O)[nH]c2cc(F)ccc12

0.661

View
COc1ccccc1OCCN(C)C(=O)c1ccc2[nH]c3ccccc3c(=O)c2c1

0.661

View
CN(CCOc1ccccc1F)C(=O)c1cc(=O)[nH]c2ccc(F)cc12

0.661

View
COc1ccccc1OCCN(C)C(=O)c1c(C)[nH]c2ccccc12

0.660

View
COc1ccccc1OCCN(C)C(=O)c1ccccc1OC

0.660

View
COc1ccccc1OCCN(C)C(=O)c1cc(Cl)nc2ccccc12

0.655

View
COc1ccccc1OCCN(C)C(=O)c1ccc(F)c2ccccc12

0.654

View
Cc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2ccc(F)cc12

0.649

View
COc1ccccc1OCCN(C)C(=O)c1ccc2c(C)cc(=O)[nH]c2c1

0.649

View
Cc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2cc(F)ccc12

0.649

View
COc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2c1CCCC2

0.649

View
COc1ccccc1OCCN(C)C(=O)c1[nH]c2ccccc2c1Cl

0.648

View
COc1ccccc1OCCN(C)C(=O)c1[nH]c2ccccc2c1Br

0.648

View
COc1ccccc1OCCN(C)C(=O)c1ccc(OC)c2ccccc12

0.647

View
COc1ccccc1OCCN(C)C(=O)c1cc(Cl)c(Cl)cc1OC

0.647

View
COc1ccccc1OCCN(C)C(=O)c1cc2c(F)cccc2[nH]1

0.643

View
COc1ccccc1OCCN(C)C(=O)c1n[nH]c2ccccc12

0.642

View
COc1cc(OC)c(C(=O)N(C)CCOc2ccccc2OC)cc1OC

0.640

View
COc1ccccc1OCCN(C)C(=O)c1cccc2[nH]c(=O)oc12

0.636

View
COc1ccccc1OCCN(C)C(=O)c1cc(C)nc2ccccc12

0.636

View
COc1ccccc1OCCN(C)C(=O)c1n[nH]c2ccccc2c1=O

0.636

View
COc1ccccc1OCCN(C)C(=O)c1cc(F)c(F)cc1F

0.635

View
COc1ccccc1OCCN(C)C(=O)c1ccccc1C(C)=O

0.633

View
COc1ccccc1OCCN(C)C(=O)c1cc(Cl)[nH]c(=O)c1

0.630

View
CCc1cc(C(=O)N(C)CCOc2ccccc2OC)cc(=O)[nH]1

0.630

View
COc1ccccc1OCCN(C)C(=O)c1c[nH]c(=O)c2ccccc12

0.630

View
COc1ccccc1OCCN(C)C(=O)c1cc(Cl)c(F)cc1Cl

0.630

View
COc1ccccc1OCCN(C)Cc1cc(=O)[nH]c2ccccc12

0.630

View
COc1ccccc1OCCN(C)C(=O)c1ccccc1F

0.627

View
COc1ccccc1OCCN(C)C(=O)c1cc(O)nc2ccccc12

0.625

View
COc1ccccc1OCCN(C)C(=O)c1cc(N(C)C)nc2ccccc12

0.625

View
COc1ccccc1OCCN(C)C(=O)c1cc(F)cc2c(=O)c3cc(F)ccc3[nH]c12

0.623

View
CN(CCOc1ccccc1Cl)C(=O)c1cc(=O)[nH]c2ccc([N+](=O)[O-])cc12

0.623

View
COc1ccccc1OCCN(C)C(=O)c1cc(F)ccc1F

0.623

View
COc1ccccc1OCCN(C)C(=O)c1cccc(F)c1F

0.623

View
COc1ccccc1OCCN(C)C(=O)c1ccc(C)cc1C

0.623

View
COc1ccccc1OCCN(C)C(=O)c1cc(F)ccc1OC

0.623

View
CCOc1ccccc1C(=O)N(C)CCOc1ccccc1OC

0.620

View
COc1ccccc1OCCN(C)C(=O)c1cncc2ccccc12

0.618

View
COc1ccccc1OCCN(C)C(=O)c1c[nH]c(=O)cc1C

0.618

View
COc1ccccc1OCCN(C)C(=O)c1cc(Cl)c2ccccc2c1O

0.618

View
COc1ccccc1OCCN(C)C(=O)c1cc(C)c(C)[nH]c1=O

0.618

View
COc1ccccc1OCCN(C)C(=O)c1cn(C)c(=O)c2ccccc12

0.618

View
CN(CCOc1ccccc1C(C)(C)C)C(=O)c1cc(=O)[nH]c2ccc(F)cc12

0.617

View
CN(CCOc1ccccc1C(C)(C)C)C(=O)c1cc(=O)[nH]c2cc(F)ccc12

0.617

View
COc1ccc(C(=O)N(C)CCOc2ccccc2OC)c(OC)c1

0.615

View
COc1ccccc1OCCN(C)C(=O)c1ccc(Cl)cc1OC

0.615

View
COc1ccccc1OCCN(C)C(=O)c1ccc(C)cc1OC

0.615

View
COc1ccccc1OCCN(C)C(=O)c1ccccc1OC(C)C

0.615

View
COc1ccccc1OCCN(C)C(=O)c1cccc(OC)c1F

0.615

View
COc1ccccc1OCCN(C)C(=O)c1cc2ccccc2cc1OC

0.615

View
COc1ccccc1OCCN(C)C(=O)c1cc(C2CC2)[nH]c(=O)c1

0.614

View
COC(=O)Cc1c(C(=O)N(C)CCOc2ccccc2OC)[nH]c2ccccc12

0.614

View
COc1ccccc1OCCN(C)C(=O)c1cc2c(ccc3ccccc32)[nH]1

0.614

View
COc1ccccc1OCCN(C)C(=O)c1ccc(F)cc1F

0.611

View
COc1ccccc1OCCN(C)C(=O)c1cc(F)c(F)cc1Cl

0.611

View
COc1ccccc1OCCN(C)C(=O)c1cc(F)c(C)cc1F

0.611

View
COc1ccccc1OCCN(C)C(=O)c1cc(F)c(F)c(F)c1F

0.611

View
COc1ccccc1OCCN(C)C(=O)c1cc2ccccc2[nH]1

0.611

View
COc1ccccc1OCCN(C)C(=O)c1cc(C)n(C)c1C

0.611

View
COc1ccccc1OCCN(C)C(=O)c1cn(C)c2ccccc12

0.611

View
COc1ccccc1OCCN(C)C(=O)c1cc(C)ccc1F

0.611

View
COc1ccccc1OCCN(C)C(=O)c1ccc(C(F)(F)F)cc1OC

0.611

View
COc1ccccc1OCCN(C)C(=O)c1cc(C)sc1C

0.611

View
COc1ccccc1OCCN(C)C(=O)c1csc2ccccc12

0.611

View
COc1ccccc1OCCN(C)C(=O)c1ccc(C)[nH]c1=O

0.611

View
COc1cc(C)c(C(=O)N(C)CCOc2ccccc2OC)cc1Cl

0.611

View
COc1ccccc1OCCN(C)C(=O)c1cc(CN)ccc1OC

0.611

View
COc1ccccc1OCCN(C)C(=O)c1cc2c(OC(F)F)cccc2[nH]1

0.610

View
COc1ccccc1OCCN(C)C(=O)c1cc2c(OC(F)(F)F)cccc2[nH]1

0.610

View
COc1ccccc1OCCN(C)C(=O)c1ccccc1Cl

0.608

View
COC(=O)c1ccccc1C(=O)N(C)CCOc1ccccc1OC

0.608

View
COCCOc1ccccc1C(=O)N(C)CCOc1ccccc1OC

0.608

View
COc1ccccc1OCCN(C)C(=O)c1ccccc1I

0.608

View
COc1ccccc1OCCN(C)C(=O)c1ccccc1C

0.608

View
COc1ccccc1OCCN(C)C(=O)c1cc2ccccc2c(=O)[nH]1

0.607

View
COc1ccccc1OCCN(C)C(=O)c1ccc(C(F)(F)F)[nH]c1=O

0.607

View
COc1ccccc1OCCN(C)C(=O)c1cccc2[nH]ncc12

0.607

View
COc1ccccc1OCCN(C)C(=O)c1cc2ccccc2c(=O)o1

0.607

View
COc1ccccc1OCCN(C)C(=O)c1cc2nn[nH]c2cc1OC

0.607

View
CCCc1cc(C(=O)N(C)CCOc2ccccc2OC)cc(=O)[nH]1

0.607

View
CN(CCOc1ccccc1F)C(=O)c1cc(=O)[nH]c2ccc([N+](=O)[O-])cc12

0.607

View
Cc1ccccc1OCCN(C)C(=O)c1cc(=O)[nH]c2ccc([N+](=O)[O-])cc12

0.607

View
COc1ccc(OC)c(C(=O)N(C)CCOc2ccccc2OC)c1

0.604

View
COc1ccccc1OCCN(C)C(=O)c1cc(C)ccc1OC

0.604

View
COc1ccccc1OCCN(C)C(=O)c1ccccc1OC(F)(F)F

0.604

View
COc1ccccc1OCCN(C)C(=O)c1ccc(Br)cc1OC

0.604

View
COC(CNC(=O)c1cc(=O)[nH]c2ccccc12)OC

0.191

View
O=C(Nc1ccc(OCCN2CCCC2)cc1)c1cc(=O)[nH]c2ccccc12

0.189

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CCOCC1

0.185

View
Cc1cccc(C)c1OC1CN(C(=O)c2cc(=O)n(C)c3ccccc23)C1

0.182

View
COCCNC(=O)c1cc(=O)[nH]c2ccccc12

0.176

View
O=C(c1cc(=O)[nH]c2ccccc12)N1CCN(CCOc2ccc(Cl)cc2)CC1

0.170

View
Cc1ccc2[nH]c(=O)cc(C(=O)N3CC(Oc4ccccc4C)C3)c2c1

0.160

View
Cc1ccc(C)c(OCCN(C)C(=O)c2cc(=O)[nH]c3ccc(F)cc23)c1

0.157

View
O=C(NCC1COc2ccccc2O1)c1cc(=O)[nH]c2ccccc12

0.156

View
CN(CCOc1ccc(OCc2ccccc2)cc1)C(=O)c1cc(=O)[nH]c2ccc(F)cc12

0.154

View
CCc1cccc(OC2CN(C(=O)c3cc(=O)[nH]c4ccccc34)C2)c1

0.150

View
CN(CC1COc2ccccc2O1)C(=O)c1cc(=O)[nH]c2ccccc12

0.143

View
COc1ccccc1OC1CN(C(=O)c2cc(=O)n(C)c3ccccc23)C1

0.128

View
CCN(CCOc1cccc(OC)c1)C(=O)c1cc(=O)[nH]c2ccc(C)cc12

0.116

View
Cc1ccc(OCCNC(=O)c2cc(=O)[nH]c3ccccc23)cc1

0.072

View
COc1ccccc1OCCNC(=O)c1cc(=O)[nH]c2ccccc12

0.025

View
C(N(CCOC1=C(OC)C=CC=C1)C)(=O)C1C2C(=CC=CC=2)N=CC=1

0.927

View
C(N(CCOC1=C(OC)C=CC=C1)C)(=O)C1C2C(=NC=CC=2)C=CC=1

0.904

View
C(N(CCOC1=C(OC)C=CC=C1)C)(=O)C1=C2C(NC=C2)=CC=C1

0.879

View
C(N(CCOC1=C(OC)C=CC=C1)C)(=O)C1C2=C(C=CC=C2)N=C(OC)C=1

0.868

View
C(N(CCCOC1=C(OC)C=CC=C1)C)(=O)C1C2C(=CC=CC=2)N=CC=1

0.862

View


Discussion: