Molecule Details

O=C(Cc1cncnc1)Nc1cc(F)cc(OC2CC(=O)N2)c1
3-aminopyridine-like Assayed
View on Fragalysis x10387
Molecular Properties
SMILES:
O=C(Cc1cncnc1)Nc1cc(F)cc(OC2CC(=O)N2)c1
MW: 316.1
Fraction sp3: 0.2
HBA: 5
HBD: 2
Rotatable Bonds: 5
TPSA: 93.21
cLogP: 1.02
Covalent Warhead:
Covalent Fragment: ✔️
Activity Data
IC50 (µM) - Fluorescence: 24.9466748468068
pIC50 (µM) - Fluorescence 4.60298733348432
Average Inhibition @ 20 µM - Fluorescence: 52.84184
Average Inhibition @ 50 µM - Fluorescence: 87.837815
Average Inhibition @ 50 µM - RapidFire: 45.74945463
Relative Solubility @ 20 µM: 0.99
Relative Solubility @ 100 µM: 0.99
Order Status
Ordered: 2020-05-17
Synthesis Location: enamine
Shipped: 2020-06-10

betalactam

b-lactam

Cc1cc(NC(=O)Cc2cncnc2)cc(OC2CC(=O)N2)c1

RAL-MED-2de63afb-2
0.704

View
N#Cc1cc(NC(=O)Cc2cncnc2)cc(OC2CC(=O)N2)c1

TRY-UNI-bbd40bb4-1
0.694

View
O=C(Cc1cncnc1)Nc1cccc(OC2CC(=O)N2)c1

BAR-COM-4e090d3a-39
0.630

View
O=C(Cc1cccnc1)Nc1cccc(OC2CC(=O)N2)c1

RAL-MED-2de63afb-1
0.469

View
Cc1ccncc1NC(=O)Cc1cc(F)cc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-2
0.466

View
O=C(Cc1cncnc1)Nc1cccc(CC2CC(=O)N2)c1

RAL-MED-2de63afb-7
0.444

View
Cc1ccncc1CC(=O)Nc1cc(C#N)cc(OC2CC(=O)N2)c1

TRY-UNI-bbd40bb4-2
0.444

View
O=C1CC(c2cccc(NC(=O)Cc3cncnc3)c2)CN1

RAL-MED-2de63afb-3
0.417

View
O=C(Cc1ccccc1)Nc1cccc(OC2CC(=O)N2)c1

RAL-MED-2de63afb-6
0.415

View
O=C(Cc1cncc2ccccc12)Nc1cc(Cl)cc(OC2CC(=O)N2)c1

ERI-UCB-ce40166b-5
0.412

View
O=C(Cc1cncnc1)Nc1cccc(CC2CCC(=O)N2)c1

RAL-MED-2de63afb-8
0.412

View
N#Cc1cc(NC(=O)Cc2cncc3ccccc23)cc(OC2CC(=O)N2)c1

ERI-UCB-ce40166b-9
0.408

View
O=C(Cc1cncnc1)Nc1cccc([C@H]2NCCNC2=O)c1

ADA-UCB-b1b30a00-3
0.402

View
O=C(Cc1cncnc1)Nc1cccnc1

SAD-SAT-24589cd1-4
0.397

View
O=C(Cc1cncnc1)Nc1cccc(CC2CNC(=O)N2)c1

RAL-MED-2de63afb-13
0.395

View
O=C1CC(Oc2cccc(C(=O)NCc3cncnc3)c2)N1

RAL-MED-2de63afb-5
0.391

View
O=C1CC(Oc2cccc(NC(=O)C(=O)c3cncnc3)c2)N1

RAL-MED-2de63afb-4
0.384

View
Cc1cc(CC(=O)Nc2cnccc2C)cc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-1
0.380

View
CCC(=O)Nc1cccc(OC2CC(=O)N2)c1

RAL-MED-2de63afb-11
0.380

View
C[C@@H](C(=O)Nc1cccc(OC2CC(=O)N2)c1)c1cncnc1

RAL-MED-2de63afb-15
0.379

View
C[C@H](C(=O)Nc1cccc(OC2CC(=O)N2)c1)c1cncnc1

RAL-MED-2de63afb-16
0.379

View
CCc1cc(CC(=O)Nc2cnccc2C)cc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-6
0.376

View
COc1cc(CC(=O)Nc2cnccc2C)cc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-5
0.376

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OC2CC(=O)N2)c1

TRY-UNI-2eddb1ff-7
0.372

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OC2CC(=O)N2)c1

WIL-MOD-03b86a88-1
0.372

View
O=C(Cc1cncnc1)Nc1cccc(N2CCC2)c1

SAD-SAT-24589cd1-2
0.361

View
Cc1ccncc1NC(=O)Cc1cc(C#N)cc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-3
0.361

View
C#Cc1cc(CC(=O)Nc2cnccc2C)cc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-4
0.361

View
Cc1ccncc1NC(=O)Cc1cc(C#N)cc(OC2CC(=O)N2)c1

TRY-UNI-2eddb1ff-6
0.361

View
O=C(Cc1cncc2ccccc12)Nc1cccc(OC2CC(=O)N2)c1

ERI-UCB-ce40166b-1
0.361

View
Cc1ccncc1NC(=O)Cc1cccc(OC2CC(=O)N2)c1

BRU-LEF-c49414a7-1
0.359

View
Cc1ccncc1NC(=O)Cc1cccc(OC2CC(=O)N2)c1

RAL-THA-901e9a10-7
0.359

View
C=CC(=O)N(C(=O)Cc1cc(C#N)cc(OC2CC(=O)N2)c1)c1cncnc1

TRY-UNI-69298daf-4
0.354

View
NC(NC(=O)Cc1cncnc1)C1CC1

MAK-UNK-748f8b7a-16
0.347

View
O=C(Cc1cc(Cl)cc(OC2CC(=O)N2)c1)Nc1cncc2ccccc12

ALP-POS-3b848b35-2
0.347

View
O=C(Cc1cc(Cl)cc(OC2CC(=O)N2)c1)Nc1cncc2ccccc12

MAT-POS-3b92565d-3
0.347

View
O=C(Cc1cc(Cl)cc(OC2CC(=O)N2)c1)Nc1cncc2ccccc12

EDJ-MED-7320d5d2-1
0.347

View
O=C(Cc1cncc2ccccc12)Nc1cc(Cl)cc(OC2CCC(=O)N2)c1

ERI-UCB-ce40166b-6
0.346

View
C=CC(=O)Nc1cccc(OC2CC(=O)N2)c1

RAL-MED-2de63afb-9
0.346

View
CC(=O)NCc1cccc(NC(=O)Cc2cncnc2)c1

RAL-MED-2de63afb-12
0.345

View
O=C(Cc1cncnc1)Nc1cccc(CCCc2ccccc2)c1

BAR-COM-4e090d3a-11
0.345

View
N#Cc1cc(NC(=O)Cc2cncc3ccccc23)cc(OC2CCC(=O)N2)c1

ERI-UCB-ce40166b-10
0.343

View
O=C(Cc1cncnc1)NC(=O)C1CC1

MAK-UNK-748f8b7a-14
0.342

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CN(C)C(NC(=O)Cc1cncnc1)C1CCC1

MAK-UNK-748f8b7a-3
0.342

View
C=CC(=O)N(C(=O)Cc1cccc(OC2CC(=O)N2)c1)c1cncnc1

TRY-UNI-69298daf-3
0.340

View
Cn1cc(NC(=O)Cc2cc(Cl)cc(OC3CC(=O)N3)c2)c2ccccc2c1=O

MAT-POS-3b92565d-9
0.337

View
O=C(Cc1cncnc1)NC1CCNCC1

MAK-UNK-748f8b7a-15
0.329

View
O=C(Cc1cc(Cl)cc(OC2CC(=O)N2)c1)Nc1nc2ccccc2[nH]1

ALP-POS-a30bcdb4-1
0.327

View
O=C(Cc1cccnc1)Nc1cccc(OC2CC(=NO)C2)c1

ANT-OPE-6e66bf84-1
0.323

View
CC(C(=O)Nc1cccc(OC2CC(=O)N2)c1)c1cnccn1

BAR-COM-4e090d3a-53
0.323

View
O=C(Cc1cncc2ccccc12)Nc1cccc(OC2CCC(=O)N2)c1

ERI-UCB-ce40166b-2
0.320

View
C/C=C/C(=O)Nc1cccc(OC2CC(=O)N2)c1

RAL-MED-2de63afb-10
0.318

View
Cc1ccncc1NC(=O)C(C)c1cc(Cl)cc(OC2CC(=O)N2)c1

TRY-UNI-2eddb1ff-8
0.316

View
CON=C1CC(Oc2cccc(NC(=O)Cc3cccnc3)c2)C1

ANT-OPE-6e66bf84-2
0.316

View
CC(NC(=O)Cc1cncnc1)NC1COCC1O

MAK-UNK-748f8b7a-10
0.313

View
O=C(Cc1cncnc1)NC1CCCNC1

MAK-UNK-748f8b7a-7
0.312

View
O=C(Cc1cc(Cl)cc(OC2CC(=O)N2)c1)Nc1cc(=O)[nH]c2ccccc12

MAT-POS-3b92565d-6
0.311

View
O=C(Cc1cncnc1)NCCOC1CNC1

MAK-UNK-748f8b7a-4
0.309

View
O=C1CC(Oc2cc(Cl)cc(CC(=O)Nn3cnc4ccccc4c3=O)c2)N1

JAN-GHE-74b8b0cb-1
0.305

View
Cc1ccncc1NC(=O)Cc1ccc(Cl)c(OC2CC(=O)N2)c1

RAL-THA-901e9a10-8
0.303

View
CCN(C(=O)Nc1cnccc1C)c1cc(Cl)cc(OC2CC(=O)N2)c1

MAR-UCB-ad2ff052-2
0.301

View
O=C(Cc1ccc(F)cc1)Nc1cccnc1

MAK-UNK-a7b37c5e-5
0.300

View
C=CC(=O)N(C(=O)Cc1cc(C#N)cc(OC2CC(=O)N2)c1)c1cccnc1

TRY-UNI-69298daf-6
0.298

View
Cc1ccncc1NC(=O)N(C)c1cc(Cl)cc(OC2CC(=O)N2)c1

MAR-UCB-ad2ff052-1
0.297

View
CCCCC(C(=O)Nc1cnccc1C)c1cc(Cl)cc(OC2CC(=O)N2)c1

JAN-GHE-f4ca5a00-15
0.296

View
O=C(Cc1cncnc1)NCN1CCNCC1

MAK-UNK-748f8b7a-5
0.296

View
O=C1CC(Oc2cc(Cl)cc(CC(=O)Nn3cnc4ccccc43)c2)N1

MAT-POS-c478e61b-1
0.295

View
O=C1CC(Oc2cc(Cl)cc(CC(=O)Nn3cnc4ccccc43)c2)N1

MAT-POS-3b92565d-12
0.295

View
CC(O)C(NC(=O)Cc1cncnc1)N(C)C

MAK-UNK-748f8b7a-12
0.295

View
Cc1ccncc1NC(=O)C(CCc1ccccc1)c1cc(Cl)cc(OC2CC(=O)N2)c1

ALP-POS-3fc1724e-6
0.295

View
O=C1CC(Oc2ccc(NC(=O)Nc3cccnc3)s2)N1

TRY-UNI-bbd40bb4-4
0.293

View
C=CC(=O)N(C(=O)Cc1cccc(OC2CC(=O)N2)c1)c1cccnc1

TRY-UNI-69298daf-5
0.293

View
O=C(Cc1cc(Cl)cc(OC2CCC(=O)N2)c1)Nc1cncc2ccccc12

MAT-POS-9ff17035-1
0.287

View
C=CC(=O)N(C(=O)Cc1cc(C#N)cc(OC2CC(=O)N2)c1)c1cnccc1C

TRY-UNI-69298daf-2
0.287

View
O=C(Cc1cncnc1)CN1CCOCC1

MAK-UNK-748f8b7a-11
0.282

View
Cc1ccncc1NC(=O)C(CCC1CCCCC1)c1cc(Cl)cc(OC2CC(=O)N2)c1

ALP-POS-3fc1724e-5
0.281

View
CC(CO)(NC1CC1)C(=O)Cc1cncnc1

MAK-UNK-748f8b7a-2
0.280

View
O=C(Cc1cccc(Cl)c1)Nc1cncnc1

JAN-GHE-5a013bed-9
0.280

View
C=CC(=O)N(C(=O)Cc1cccc(OC2CC(=O)N2)c1)c1cnccc1C

TRY-UNI-69298daf-1
0.279

View
O=C(Cc1cncnc1)CN1CCNCC1

MAK-UNK-748f8b7a-1
0.278

View
Cc1ccncc1NC(=O)N(CCC1CCCCC1)c1cc(Cl)cc(OC2CC(=O)N2)c1

MAR-UCB-ad2ff052-3
0.274

View
Cc1ccncc1NC(=O)N(CCC1CCCCC1)c1cc(Cl)cc(OC2CC(=O)N2)c1

DAR-DIA-1d7f034a-1
0.274

View
CC1(OCC(=O)Cc2cncnc2)CNC1

MAK-UNK-748f8b7a-8
0.272

View
Cc1ccncc1NC(=O)Nc1ccc(OC2CC(=O)N2)s1

TRY-UNI-bbd40bb4-6
0.265

View
O=C1CC(Oc2cc(Cl)cc(C(CCc3ccccc3)C(=O)Nc3nc4ccccc4[nH]3)c2)N1

ALP-POS-a30bcdb4-2
0.265

View
O=C1CC(c2ccc(NC(=O)c3cncnc3)cc2)NC(=O)N1

MAR-TRE-66ac689e-2
0.264

View
O=C(Cn1c(=O)c2cc(C3CC3)nn2c2ncccc21)Nc1cc(F)cc(F)c1

MAR-TRE-d0525fbf-94
0.262

View
CC1COC(CO)CN1CNC(=O)Cc1cncnc1

MAK-UNK-748f8b7a-13
0.261

View
O=C(NC1CC(=O)N(CCN2CCOCC2)C1)c1cncnc1

MAR-TRE-c317dd82-69
0.260

View
COc1cc(F)cc(NC(=O)C(=O)[C@H](C[C@@H]2CCNC2=O)NC(=O)[C@H](CC(C)C)NC(=O)NCc2ccccc2)c1

YUN-WES-64c64eb2-6
0.260

View
COc1cc(F)cc(NC(=O)C(=O)[C@H](C[C@@H]2CCNC2=O)NC(=O)[C@H](CC(C)C)NC(=O)NCc2ccccc2)c1

YUN-WES-58b0dbae-8
0.260

View
O=C1CCC(N2Cc3cc(CC(=O)Nc4cccnc4)ccc3C2=O)C(=O)N1

MAR-TRE-2fd8122f-3
0.257

View
O=C(NCc1cc(C2OCCO2)ccc1F)c1cncnc1

MAR-TRE-799db12b-7
0.255

View
Cc1ccncc1CN1C(=O)C(=O)c2ccc(-c3cc(Cl)cc(OC4CC(=O)N4)c3)cc21

DAR-DIA-53551c05-7
0.254

View
O=C1CC(Oc2cc(Cl)cc(-c3ccc4c(c3)N(Cc3cncc5ccccc35)C(=O)C4=O)c2)N1

DAR-DIA-53551c05-11
0.254

View
O=C(O)c1ccc(F)c(CNC(=O)c2cncnc2)c1

MAR-TRE-8190bb11-42
0.253

View
O=C1CC(Oc2cc(Cl)cc(OCCNC(=O)c3cc(=O)[nH]c4ccccc34)c2)N1

ERI-UCB-ce40166b-17
0.252

View
O=C1CC(Oc2cc(Cl)cc(OCCNC(=O)c3cc(=O)[nH]c4ccccc34)c2)N1

ALP-POS-3fc1724e-2
0.252

View
CCCC(C(=O)Nn1cnc2ccccc2c1=O)c1cc(Cl)cc(OC2CC(=O)N2)c1

JAN-GHE-74b8b0cb-2
0.252

View
O=C1CC(Oc2cc(Cl)cc(C(CCc3ccccc3)C(=O)Nn3cnc4ccccc43)c2)N1

MAT-POS-c478e61b-2
0.250

View
COC1=CC(F)=CC(NC(=O)CC2=CN=CN=C2)=C1

0.618

View
CC(C)OC1=CC(F)=CC(NC(=O)CC2=CN=CN=C2)=C1

0.606

View
O=C(CC1=CN=CN=C1)NC1=CC(NC(=O)CC2=CN=CN=C2)=CC(F)=C1

0.562

View
CC1=CC(F)=CC(NC(=O)CC2=CN=CN=C2)=C1

0.544

View
O=C(CC1=CN=CN=C1)NC1=CC(F)=CC(Br)=C1

0.544

View
O=C(CC1=CN=CN=C1)NC1=CC(F)=CC(Cl)=C1

0.514

View
COC1=CC(NC(=O)CC2=CN=CN=C2)=CC(OC)=C1

0.486

View
O=C(CC1=CN=CN=C1)NC1=CC=C(F)C=C1

0.471

View
O=C(CC1=CN=CN=C1)NC1=CC(N2CCCC2)=CC(F)=C1

0.468

View
COC1=C(F)C=C(NC(=O)CC2=CN=CN=C2)C=C1F

0.466

View
O=C(CC1=CN=CN=C1)NC1=CC(F)=C(I)C(F)=C1

0.465

View
C[C@H]1CN(C2=CC(F)=CC(NC(=O)CC3=CN=CN=C3)=C2)C[C@@H](C)O1

0.464

View
COC1=CC(Br)=CC(NC(=O)CC2=CN=CN=C2)=C1

0.461

View
O=C(CC1=CN=CN=C1)NC1=CC(F)=CC=C1

0.452

View
O=C(CC1=CN=CN=C1)NC1=CC(N2CCOCC2)=CC(F)=C1

0.451

View
O=C(CC1=CN=CN=C1)NC1=CC=CC(OC2CCCC2)=C1

0.451

View
COC1=CC(NC(=O)CC2=CN=CN=C2)=CC(O)=C1

0.447

View
O=C(CC1=CN=CN=C1)NC1=CC=C(OC2CCC2)C(F)=C1

0.444

View
O=C(CC1=CN=CN=C1)NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1

0.444

View
COC1=CC(F)=CC(NC(=O)CCC2=CN=CN=C2)=C1

0.443

View
O=C(CC1=CN=CN=C1)NC1=CC=C(OC2CC2(F)F)C=C1

0.443

View
O=C(CC1=CN=CN=C1)NC1=CC=C(OC2CCCC2)C=C1

0.443

View
CC1=CC(C)=CC(NC(=O)CC2=CN=CN=C2)=C1

0.443

View
CC(C)OC1=C(F)C=C(NC(=O)CC2=CN=CN=C2)C=C1F

0.442

View
CC(C)(C)OC1=C(F)C=C(NC(=O)CC2=CN=CN=C2)C=C1F

0.442

View
CC(C)OC1=CC(F)=CC(NC(=O)CCC2=CN=CN=C2)=C1

0.439

View
COC(=O)C1=CC(NC(=O)CC2=CN=CN=C2)=CC(C(=O)OC)=C1

0.438

View
CC(C)OC1=CC(Br)=CC(NC(=O)CC2=CN=CN=C2)=C1

0.438

View
O=C(CC1=CN=CN=C1)N[C@H]1CCC[C@H]1OC1=CC(F)=CC(F)=C1

0.434

View
COC1=CC(NC(=O)CC2=CN=CN=C2)=CC(OC)=C1OC

0.432

View
COC1=CC(F)=CC(NC(=O)CC2=CC=CN=C2)=C1

0.430

View
O=C(CC1=CN=CN=C1)NC1=CC(F)=C(N2CCCC2)C(F)=C1

0.430

View
COC1=CC(F)=CC(NC(=O)CC2=CC=NC=C2)=C1

0.429

View
O=C(CC1=CN=CN=C1)NC1=CC(OCC2=CC=C(F)C=C2)=CC=C1

0.429

View
O=C(CC1=CN=CN=C1)NC1=CC=C(OC2CCCC2)C(F)=C1

0.429

View
O=C(CC1=CN=CN=C1)NC1=CC=C(OC2=CC(F)=CC=C2)C=C1

0.427

View
CC(C)OC1=CC(F)=CC(NC(=O)CC2=CC=CN=C2)=C1

0.427

View
CC(C)OC1=CC(F)=CC(NC(=O)CC2=CN(C)N=C2)=C1

0.427

View
COC1=C(Cl)C=C(NC(=O)CC2=CN=CN=C2)C=C1Cl

0.427

View
COC1=CC(F)=CC(NNC(=O)CC2=CN=CN=C2)=C1

0.425

View
CC(C)OC1=CC(F)=CC(NC(=O)CC2=CC=NC=C2)=C1

0.425

View
O=C(CC1=CN=CN=C1)NC1=CC=C(F)C(F)=C1

0.425

View
NC1=C(Cl)C=C(NC(=O)CC2=CN=CN=C2)C=C1Cl

0.425

View
O=C(CC1=CN=CN=C1)NC1=CN=CN=C1

0.424

View
CC(C)OC1=CC(NC(=O)CC2=CN=CN=C2)=CC(C(F)(F)F)=C1

0.422

View
O=C(CC1=CN=CN=C1)NC1=CC(F)=C(N2CCCCC2)C(F)=C1

0.420

View
COC1=CC(F)=CC(NC(=O)CC2CC(=O)N2)=C1

0.418

View
CC(C)OC1=CC(F)=CC(NC(=O)CC2CC(=O)N2)=C1

0.415

View
CC(C)OC1=CC(F)=CC(NC(=O)CC2=C[NH]N=C2)=C1

0.415

View
O=C(CC1=CN=CN=C1)NC1=CC=C(OC2=CC(F)=CC=C2)N=C1

0.414

View
O=C(CC1=CN=CN=C1)NC1=CC(OC(F)F)=CC=C1

0.412

View
COC1=CC=CC(NC(=O)CC2=CN=CN=C2)=C1

0.410

View
COC1=CC(F)=CC(NC(=O)CC2=CN=CC(C)=C2)=C1

0.407

View
O=C(CC1CC(=O)N1)NC1=CC(OC(F)F)=CC(F)=C1

0.407

View
COC1=CC(F)=CC(NC(=O)CC2=CC=C(CC(=O)NC3=CC(F)=CC(OC)=C3)C=C2)=C1

0.405

View
CC1=CC(CC(=O)NC2=CC(OC(C)C)=CC(F)=C2)=CN=C1

0.405

View
CC(C)OC1=CC(F)=CC(NC(=O)CC2=CN=CC(O)=C2)=C1

0.405

View
O=C(CC1=CN=CN=C1)NC1=CC=CC=C1OC1=CC(F)=CC(F)=C1

0.400

View
CC1=CC(C)=CC(CC(=O)NC2=CC=CC(OC3CC(=O)N3)=C2)=C1

0.400

View
CCC1=CC=C(CC(=O)NC2=CC=CC(OC3CC(=O)N3)=C2)C=C1

0.400

View
CC1=CC(C)=CC(CC(=O)NC2=CC=C(OC3CC(=O)N3)C=C2)=C1

0.398

View
COC1=CC(CC(=O)NC2=CC=CC(OC3CC(=O)N3)=C2)=CC(OC)=C1

0.395

View
O=C(CC1=CN=CN=C1)NC1=CC(OCC2=CC(F)=CC=C2)=CC=C1

0.393

View
O=C(CC1=CN=CN=C1)NC1=CC(COC2=CC(F)=CC=C2)=CC=C1

0.393

View
COC1=CC(CC(=O)NC2=CC=C(OC3CC(=O)N3)C=C2)=CC(OC)=C1

0.393

View
CCCC1=CC=C(CC(=O)NC2=CC=CC(OC3CC(=O)N3)=C2)C=C1

0.391

View
CC(C)(C)C1=CC=C(CC(=O)NC2=CC=CC(OC3CC(=O)N3)=C2)C=C1

0.391

View
COC1=CC(CC(=O)NC2=CC=CC(OC3CC(=O)N3)=C2)=CC(OC)=C1OC

0.386

View
CC1=CC=C(CC(=O)NC2=CC=CC(OC3CC(=O)N3)=C2)C=C1C

0.386

View
O=C(CC1=CN=CN=C1)NC1=CC=CC(OC2=CC=CC=C2)=C1

0.386

View
CCC1=CC=C(CC(=O)NC2=CC=C(OC3CC(=O)N3)C=C2)C=C1

0.386

View
O=C(CC1=CC=C2CCCCC2=C1)NC1=CC=CC(OC2CC(=O)N2)=C1

0.385

View
CC1=CC=C(CC(=O)NC2=CC=C(OC3CC(=O)N3)C=C2)C=C1C

0.384

View
COC1=C(F)C=C(F)C=C1NC(=O)CC1=CN=CN=C1

0.383

View
CCOC1=CC=C(CC(=O)NC2=CC=CC(OC3CC(=O)N3)=C2)C=C1

0.382

View
CC(C)CC1=CC=C(CC(=O)NC2=CC=CC(OC3CC(=O)N3)=C2)C=C1

0.382

View
O=C(CC1=CC=CC(C2CC2)=C1)NC1=CC=CC(OC2CC(=O)N2)=C1

0.382

View
O=C(CC1=CC=C2CCCCC2=C1)NC1=CC=C(OC2CC(=O)N2)C=C1

0.382

View
O=C(CC1=CC=C2CCCC2=C1)NC1=CC=CC(OC2CC(=O)N2)=C1

0.380

View
COC1=CC(CC(=O)NC2=CC=C(OC3CC(=O)N3)C=C2)=CC(OC)=C1OC

0.379

View
CCSC1=CC=C(CC(=O)NC2=CC=CC(OC3CC(=O)N3)=C2)C=C1

0.378

View
O=C(CC1=CC=C2CCCC2=C1)NC1=CC=C(OC2CC(=O)N2)C=C1

0.378

View
CC(C)OC1=CC=CC(CC(=O)NC2=CC=CC(OC3CC(=O)N3)=C2)=C1

0.374

View
COCC1=CC=CC(CC(=O)NC2=CC=CC(OC3CC(=O)N3)=C2)=C1

0.374

View
O=C(CC1=CC(OCC(F)(F)F)=CC=C1)NC1=CC=CC(OC2CC(=O)N2)=C1

0.372

View
O=C(CC1=CC=C2COCC2=C1)NC1=CC=CC(OC2CC(=O)N2)=C1

0.372

View
CCOC1=CC=C(CC(=O)NC2=CC=C(OC3CC(=O)N3)C=C2)C=C1

0.372

View
O=C(CC1=CC=C(N2C=CC=C2)C=C1)NC1=CC=CC(OC2CC(=O)N2)=C1

0.370

View
CN1C=C(SCC(=O)NC2=CC=CC(OC3CC(=O)N3)=C2)C=N1

0.370

View
CC1=CC=CC(C)=C1CC(=O)NC1=CC=CC(OC2CC(=O)N2)=C1

0.368

View
CN1N=CC=C1CC(=O)NC1=CC=CC(OC2CC(=O)N2)=C1

0.367

View
CN1C=CC(CC(=O)NC2=CC=CC(OC3CC(=O)N3)=C2)=N1

0.367

View
CN1N=CC(Cl)=C1CC(=O)NC1=CC=CC(OC2CC(=O)N2)=C1

0.366

View
O=C(CC1CC(=O)N1)NC1=CC=CC(OC2CC(=O)N2)=C1

0.361

View
O=C(CC1CC(=O)N1)NC1=CC(F)=CC(F)=C1

0.360

View
CC(C)(CNC(=O)CC1=CN=CN=C1)OC1=CC(F)=CC(F)=C1

0.357

View
COC1=CC(F)=CC(NC(=O)CC2=CN=CN2C)=C1

0.357

View
CC(C)OC1=CC(F)=CC(NC(=O)CC2=CN=CN2C)=C1

0.356

View
CC1=NN(C)C(C)=C1CC(=O)NC1=CC=CC(OC2CC(=O)N2)=C1

0.355

View
CN1N=CC(Cl)=C1CC(=O)NC1=CC=C(OC2CC(=O)N2)C=C1

0.352

View

C(NC1C=CC=C(OC)C=1)(=O)CC1=CN=CN=C1

0.410

View
C(NC1=CC(F)=C(OC)C=C1)(=O)CC1=CN=CN=C1

0.405

View
C(NC1C=CC(F)=C(OC)C=1)(=O)CC1=CN=CN=C1

0.400

View
C(NC1C=CC=C(OC(C)C)C=1)(=O)CC1=CN=CN=C1

0.395

View
C(NC1=C(OCC)C=CC(F)=C1)(=O)CC1=CN=CN=C1

0.390

View
C(NC1=CC=CC(OCC#N)=C1)(=O)CC1=CN=CN=C1

0.376

View
C(NC1C=CC=C(OCC#C)C=1)(=O)CC1=CN=CN=C1

0.376

View
C(NC1=CC=C(OCCCC)C=C1)(=O)CC1=CN=CN=C1

0.370

View


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