Molecule Details

Cc1ccncc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21
Ugi Enamine Assayed
View on Fragalysis x10638
Molecular Properties
SMILES:
Cc1ccncc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21
MW: 331.07
Fraction sp3: 0.19
HBA: 4
HBD: 1
Rotatable Bonds: 3
TPSA: 71.53
cLogP: 2.41
Covalent Warhead:
Covalent Fragment:
Source
Enamine REAL: Z1129286283
Enamine Extended REAL: s_22____3391102____242262
Activity Data
IC50 (µM) - Fluorescence: 59.9331319543654
IC50 (µM) - RapidFire: 38.9272880340427
Trypsin IC50 (µM): 99.0
pIC50 (µM) - Fluorescence 4.22233302657587
Average Inhibition @ 20 µM - Fluorescence: 32.761255
Average Inhibition @ 50 µM - Fluorescence: 49.274905
Average Inhibition @ 50 µM - RapidFire: 67.195
Relative Solubility @ 20 µM: 0.99
Relative Solubility @ 100 µM: 0.99
Order Status
Ordered: 2020-05-30
Synthesis Location: enamine
Shipped: 2020-06-24
CS(=O)(=O)NCCc1ccccc1

AAR-POS-d2a4d1df-1

View

O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cccnc1

KEI-TRE-d5e2018a-6
0.631

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cccnc1

MAR-TRE-2fd8122f-9
0.631

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cccnc1

MAR-TRE-7f7bb9f0-84
0.631

View
Cc1ccncc1NC(=O)Cn1ccc2ccc(Cl)cc21

BAR-COM-0f94fc3d-41
0.444

View
Cc1ccncc1NC(=O)CN1CCCC1=O

BEN-DND-22e6b372-4
0.435

View
Cc1ccncc1NC(=O)CN1CCOCC1

BEN-DND-93268d01-10
0.434

View
Cc1ccncc1NC(=O)CN1CCN(C)C(=O)C1

BEN-DND-6de5dfa0-5
0.430

View
Cc1ccncc1NC(=O)CN1CCCCC1=O

BEN-DND-22e6b372-3
0.425

View
Cc1ccncc1NC(=O)Cc1cccc(Cl)c1

TRY-UNI-714a760b-6
0.424

View
Cc1ccncc1NC(=O)CN1CCCCC1

BEN-DND-93268d01-11
0.422

View
Cc1ccncc1NC(=O)CN1CCN(C)CC1

BEN-DND-93268d01-9
0.422

View
Cc1ccncc1NC(=O)CN1CCN(C)CC1=O

BEN-DND-22e6b372-2
0.416

View
CC(=O)N1CCN(CC(=O)Nc2cnccc2C)CC1

BEN-DND-93268d01-8
0.412

View
Cc1ccncc1NC(=O)CN1CCNC(=O)C1

BEN-DND-6de5dfa0-4
0.409

View
Cc1ccncc1NC(=O)CCl

MAK-UNK-6ca90168-26
0.408

View
CC(=O)N1CCN(CC(=O)Nc2cnccc2C)C(=O)C1

BEN-DND-22e6b372-1
0.407

View
Cc1ccncc1NC(=O)C1CCOc2ccc(Cl)cc21

JAN-GHE-f4ca5a00-13
0.406

View
Cc1ccncc1NC(=O)C1CCOc2ccc(Cl)cc21

DAR-DIA-6a508060-6
0.406

View
Cc1ccncc1NC(=O)C1CCOc2ccc(Cl)cc21

BRU-CON-c4e3408a-1
0.406

View
Cc1ccncc1NC(=O)[C@H]1CCOc2ccc(Cl)cc21

MAT-POS-b3e365b9-3
0.406

View
Cc1ccncc1NC(=O)[C@@H]1CCOc2ccc(Cl)cc21

MAT-POS-b3e365b9-4
0.406

View
Cc1ccncc1NC(=O)CN1CCN(C(=O)CCl)CC1

BEN-DND-6de5dfa0-16
0.404

View
CCCCOc1ccc(Cl)cc1CC(=O)Nc1cnccc1C

EDG-MED-0da5ad92-7
0.400

View
Cc1ccncc1NC(=O)CN1CCN(S(C)(=O)=O)CC1

BEN-DND-6de5dfa0-3
0.398

View
Cc1ccncc1NC(=O)Cc1cc(Cl)c2c(c1)OCCO2

BAR-COM-0f94fc3d-28
0.396

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(NC23CC(C2)C3)c1

MAT-POS-e501d84c-1
0.396

View
CC(=O)N(C)C1CCN(CC(=O)Nc2cnccc2C)CC1

BEN-DND-6de5dfa0-15
0.396

View
COc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

MAT-POS-c9973a83-1
0.396

View
Cc1ccncc1NC(=O)Cc1cncc(Cl)c1

EDG-MED-0da5ad92-8
0.395

View
Cc1ccncc1NC(=O)Cc1cncc(Cl)c1

TRY-UNI-2eddb1ff-2
0.395

View
Cc1ccncc1NC(=O)CC(C)C(C)C

MAT-POS-590ac91e-11
0.395

View
Cc1ccncc1NC(=O)CCCBr

ALE-HEI-f28a35b5-12
0.395

View
CNS(=O)(=O)c1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-14
0.394

View
CCC(=O)N1CCN(CC(=O)Nc2cnccc2C)CC1

BEN-DND-6de5dfa0-1
0.393

View
O=C(CN1C(=O)COc2ccccc21)Nc1cccnc1

KEI-TRE-d5e2018a-37
0.389

View
O=C(CN1C(=O)COc2ccccc21)Nc1cccnc1

MAR-TRE-4b834d9a-45
0.389

View
O=C(CN1C(=O)COc2ccccc21)Nc1cccnc1

MAR-TRE-2fd8122f-91
0.389

View
Cc1ccncc1NC(=O)CCc1cccc(Cl)c1

ALP-POS-f13221e1-4
0.389

View
CCOC(=O)N1CCN(CC(=O)Nc2cnccc2C)CC1

BEN-DND-6de5dfa0-7
0.389

View
Cc1ccncc1NC(=O)CC1CC2CC2C1

MAT-POS-590ac91e-23
0.388

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(S(N)(=O)=O)c1

RAL-THA-6b94ceba-13
0.387

View
Cc1ccncc1NC(=O)Cc1cccc(Br)c1

JAN-GHE-83b26c96-12
0.386

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C2COC2)c1

WIL-MOD-03b86a88-2
0.385

View
CC(=O)NC1CCN(CC(=O)Nc2cnccc2C)CC1

BEN-DND-6de5dfa0-14
0.385

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OC2COC2)c1

WIL-MOD-03b86a88-4
0.384

View
Cc1cc(CC(=O)Nc2cnccc2C)[nH]n1

EDJ-MED-c9f55a56-1
0.384

View
CC(=O)NCc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-5
0.383

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(CS(N)(=O)=O)c1

RAL-THA-6b94ceba-15
0.383

View
Cc1ccncc1NC(=O)Cc1cccc(CN2CCOCC2)c1

SAD-SAT-7d5528d9-1
0.381

View
Cc1ccncc1NC(=O)CN1CCCc2ccccc21

BEN-DND-93268d01-12
0.381

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(-c2cnc[nH]2)c1

RAL-THA-6b94ceba-11
0.381

View
Cc1ccncc1NC(=O)CN1CCCc2ccccc21

BEN-DND-6de5dfa0-13
0.381

View
CC(=O)N1CCCN(CC(=O)Nc2cnccc2C)CC1

BEN-DND-6de5dfa0-6
0.380

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C(N)=O)c1

RAL-THA-6b94ceba-6
0.380

View
Cc1ccncc1NC(=O)Cn1ccc2ccc(F)cc21

BAR-COM-0f94fc3d-18
0.379

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(NS(C)(=O)=O)c1

WIL-MOD-03b86a88-5
0.379

View
CNS(=O)(=O)Cc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-16
0.379

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(CNS(C)(=O)=O)c1

RAL-THA-6b94ceba-12
0.379

View
Cc1ccncc1NC(=O)CN1CCN(C(=O)c2ccccc2)CC1

BEN-DND-6de5dfa0-2
0.379

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OC2CC(=O)N2)c1

WIL-MOD-03b86a88-1
0.376

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OC2CC(=O)N2)c1

TRY-UNI-2eddb1ff-7
0.376

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(NS(N)(=O)=O)c1

WIL-MOD-03b86a88-6
0.375

View
Cc1ccncc1NC(=O)CC#N

ASH-SAT-43770c7d-9
0.375

View
COC(=O)NCc1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-8
0.375

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(NC2C(C(F)(F)F)C2C(F)(F)F)c1

MAT-POS-044491d2-4
0.374

View
CNC(=O)c1cc(Cl)cc(CC(=O)Nc2cnccc2C)c1

RAL-THA-6b94ceba-7
0.372

View
CC(=O)Nc1ccc(NCC(=O)Nc2cnccc2C)cc1

GAB-REV-70cc3ca5-21
0.372

View
Cc1ccncc1NC(=O)N(c1cccc(Cl)c1)c1cccc(Cl)c1

EDG-MED-0da5ad92-19
0.371

View
Cc1ccncc1NC(=O)N(C)c1cccc(Cl)c1

EDG-MED-0da5ad92-3
0.371

View
Cc1ccncc1NC(=O)Cc1cccc(F)c1

ALP-POS-95b75b4d-1
0.371

View
Cc1ccncc1NC(=O)C1CCN(Cc2cccc(Cl)c2)CC1

SAD-SAT-7d5528d9-7
0.370

View
Cc1ccncc1NC(=O)CCc1nc2cc(Cl)ccc2o1

GAB-REV-70cc3ca5-22
0.370

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OCCN2CCOC[C@H]2C)c1

CHO-MSK-6e55470f-1
0.369

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OCCN2CCOCC2C)c1

MAT-POS-500ca5bf-1
0.369

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OCc2ccn[nH]2)c1

RAL-THA-6b94ceba-4
0.369

View
Cc1ccncc1NC(=O)CN1CCn2c(cnc2C)C1

BEN-DND-6de5dfa0-9
0.368

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OCc2ncn[nH]2)c1

RAL-THA-6b94ceba-2
0.365

View
Cc1noc(COc2cc(Cl)cc(CC(=O)Nc3cnccc3C)c2)n1

CHO-MSK-6e55470f-5
0.365

View
Cc1ccncc1NC(=O)CC1(CO)CC1

MAT-POS-590ac91e-6
0.365

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(C(C)C(N)=O)c1

WIL-MOD-03b86a88-3
0.365

View
Cc1ccncc1NC(=O)CN1CCn2c(C)cnc2C1

BEN-DND-6de5dfa0-8
0.365

View
Cc1ccncc1NC(=O)CC1(C#N)CCC1

MAT-POS-590ac91e-15
0.364

View
Cc1ccncc1NC(=O)Cc1ccccc1N

ANN-UNI-98d2bf15-1
0.364

View
Cc1ccncc1NC(=O)Cc1ccc(Cl)c(OC2CC(=O)N2)c1

RAL-THA-901e9a10-8
0.363

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(CC2CC3(CC3)N2)c1

DAR-DIA-23e5a6a0-29
0.363

View
CC(=O)NCc1cc2c(cc1CCCC(=O)Nc1cnccc1C)OCO2

NAT-WAB-78d8bb1c-1
0.363

View
Cc1ccncc1NC(=O)CC12CCCC1C2

MAT-POS-590ac91e-25
0.363

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OC2CC3(COC3)N2)c1

DAR-DIA-23e5a6a0-26
0.362

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(CC2CC3(CC3)CN2)c1

DAR-DIA-23e5a6a0-27
0.362

View
Cc1ccncc1NC(=O)CC(O)C1CC1

MAT-POS-590ac91e-7
0.360

View
COC1(CC(=O)Nc2cnccc2C)CC1

MAT-POS-590ac91e-9
0.360

View
Cc1ccncc1NC(=O)Cc1cccc(O)c1

ALP-POS-95b75b4d-2
0.360

View
Cc1ccncc1NC(=O)Cc1cccc(I)c1

JAN-GHE-83b26c96-13
0.360

View
Cc1ccncc1NC(=O)Cc1cccc(CO)c1

EDJ-MED-e58735b6-2
0.360

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(OC2CC3(CC3)N2)c1

DAR-DIA-23e5a6a0-30
0.359

View
Cc1ccncc1NC(=O)Cc1cc(Cl)cc(NC2CCC(F)(F)C2O)c1

MAT-POS-044491d2-2
0.359

View
Cc1ccncc1NC(=O)Cc1cnn(C2(Cl)CC2)c1

DAR-DIA-0cde14eb-62
0.358

View
Cc1ccncc1NC(=O)C1(c2cccc(Cl)c2)CC(=O)C1

BAR-COM-0f94fc3d-25
0.358

View
Cc1ccncc1NC(=O)Cc1cccc(C2(F)CC2)c1

DAR-DIA-0cde14eb-2
0.358

View
Cc1ccncc1NC(=O)Cc1cccc2c1CNCC2

ADA-UCB-6c2cb422-4
0.357

View
Cc1ccncc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

1.000

View
Cc1cnccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.868

View
CC(=O)Nc1ccncc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.789

View
CSc1ccncc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.789

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cnccc1O

0.786

View
Cc1cnncc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.782

View
COc1ccncc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.776

View
Cc1ccc(Cl)cc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.774

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccncc1F

0.768

View
Cc1ccncc1NC(=O)CN1C(=O)COc2ccccc21

0.764

View
Cc1ccc(-c2ccncc2)cc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.763

View
CC(C)(C)Oc1ccncc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.763

View
CCc1cnccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.759

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccncc1Br

0.754

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccncc1I

0.754

View
Cc1cc(Cl)ncc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.754

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccncc1O

0.754

View
Cc1cnn(-c2ccncc2NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1

0.754

View
Cc1nccn1-c1ccncc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.754

View
Cc1ccc(-c2cccnc2)cc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.754

View
Cc1ccncc1NC(=O)CN1C(=O)COc2ccc([N+](=O)[O-])cc21

0.750

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cnccc1-c1ccccc1

0.746

View
Cc1ccccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.745

View
Cc1cc(Cl)ccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.741

View
CN1CCN(c2ccncc2NC(=O)CN2C(=O)COc3ccc(Cl)cc32)CC1

0.738

View
Cc1ccc(C)c(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1

0.732

View
N#Cc1cnccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.729

View
Cc1cc(Br)ncc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.729

View
Cc1cc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c(C)cn1

0.724

View
Cc1cc(C(F)(F)F)ncc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.721

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cncc(Cl)c1Cl

0.719

View
Cc1nnccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.719

View
Cc1ccncc1NC(=O)CN1C(=O)COc2cc(Br)ccc21

0.712

View
Cc1cnccc1CNC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.712

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cnccc1-n1cccn1

0.710

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccncc1

0.709

View
Cc1ccc(Br)cc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.707

View
Cc1ccc(F)cc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.707

View
Cc1ncccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.707

View
Cc1cc(O)ccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.707

View
Cc1nccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1Cl

0.707

View
Cc1ccc(N)cc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.707

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cccc2cnccc12

0.705

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cccc2ccncc12

0.705

View
Cc1ccncc1CCNC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.705

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccncc1N1CCOCC1

0.705

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccnc2ccncc12

0.705

View
Cc1ccncc1C(C)NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.705

View
Cc1cscc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.702

View
Cc1cc(Cl)c(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)cc1Cl

0.702

View
Cc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c(Cl)c1Cl

0.702

View
Cc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c(C)c1

0.702

View
Cc1ccc(C(=O)N(C)C)cc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.700

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cnccc1Oc1ccccc1

0.698

View
Cc1cnc(Cl)c(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1

0.695

View
Cc1ccncc1N(C)C(=O)CN1C(=O)COc2ccc(Cl)cc21

0.695

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cncc(Cl)c1Br

0.695

View
Cc1ccc(CO)cc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.695

View
Cc1ccc(C(N)=O)cc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.695

View
Cc1ncc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c(C)n1

0.695

View
Cc1c(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)cnn1C

0.695

View
CSc1ccc(C)c(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1

0.695

View
Cc1ccc(C(=O)O)cc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.695

View
Cc1cc(Cl)cc(C)c1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.691

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cccnc1

0.690

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cnccn1

0.690

View
Cc1cc2c(cc1NC(=O)CN1C(=O)COc3ccc(Cl)cc31)OCO2

0.690

View
Cc1cccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1Cl

0.690

View
Cc1cccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1C

0.690

View
Cc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c(C)n1

0.690

View
Cc1nc(Cl)ccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.690

View
Cc1cc(Cl)cc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1O

0.690

View
Cc1cnccc1CCNC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.689

View
Cc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)cc1NC(=O)c1ccncc1

0.688

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cnccc1-c1cccc(F)c1

0.688

View
Cc1ccc(-c2ccnn2C)cc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.688

View
Cc1ccc(-c2cncc(F)c2)cc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.688

View
COC(=O)c1ccc(C)c(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1

0.683

View
CNC(=O)c1ccc(C)c(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1

0.683

View
CC(=O)Nc1ccc(C)c(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1

0.683

View
Cc1nccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1Br

0.683

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cncc2ccccc12

0.683

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cc(Cl)ccc1Br

0.679

View
Cc1cc(F)ccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.678

View
Cc1ccc(Br)c(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1

0.678

View
Cc1cc(Cl)cnc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.678

View
Cc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c(Cl)n1

0.678

View
Cc1cc(I)ccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.678

View
Cc1cc(Br)ccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.678

View
Cc1cncc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1

0.678

View
Cc1cc(C)c(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)cc1O

0.678

View
Cc1nn(C)cc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.678

View
CN(C)c1ncncc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.677

View
CC(C)c1ncncc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.677

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cc(Cl)ccc1Cl

0.673

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccc(Cl)cc1Cl

0.673

View
Cc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c(Cl)c1

0.672

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cccnc1Cl

0.672

View
Cc1nc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)oc1C

0.672

View
Cc1ccc(Cl)c(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1

0.672

View
Cc1cc(Cl)ccc1NC(=O)CN1C(=O)COc2ccccc21

0.192

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccccc1Br

0.191

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)N1CCOCC1

0.191

View
CCN(C(=O)CN1C(=O)C(C)Oc2ccccc21)c1cccnc1

0.190

View
COc1ccc(N2CCN(C(=O)CN3C(=O)COc4ccc(Cl)cc43)CC2)cc1

0.190

View
CCN(C(=O)CN1C(=O)COc2ccc(Cl)cc21)c1cccc(C)c1

0.190

View
O=C(CN1C(=O)COc2ccccc21)Nc1cc(Cl)ccc1OCC(F)(F)F

0.189

View
COc1ccc(NC(=O)CN2C(=O)COc3ccccc32)cc1Cl

0.188

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)NCCN1CCOCC1

0.188

View
CC(C)c1ccccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.188

View
CC(C)(C)c1ccccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.188

View
COc1ccc(NC(=O)CN2C(=O)COc3ccccc32)cn1

0.188

View
Cc1ccc(NC(=O)CN2C(=O)COc3ccccc32)cc1Cl

0.188

View
Cc1cc(I)cc(C)c1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.187

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccccc1C(F)(F)F

0.187

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccc(NC(=O)Nc2ccccc2)cc1

0.187

View
CCC(C)NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.187

View
CCCCNC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.187

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccccc1Cl

0.186

View
CCCOc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)cc1

0.186

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)NCc1cccnc1

0.185

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccc2ccccc2c1

0.185

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccc(I)cc1

0.185

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccccc1OC(F)(F)F

0.185

View
CC1Oc2ccccc2N(CC(=O)Nc2cccnc2)C1=O

0.185

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)NC1CC1

0.183

View
COc1ccc(OC)c(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1

0.183

View
COc1ccc(C)cc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.183

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccc(F)cc1

0.183

View
Cc1c(Cl)cccc1NC(=O)CNC(=O)CN1C(=O)COc2ccccc21

0.183

View
COc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c(OC)c1

0.183

View
Cc1ccc(Cl)cc1NC(=O)CN1C(=O)COc2cc(Cl)ccc21

0.182

View
Cc1c(Cl)cccc1NC(=O)CN1C(=O)COc2cc(Cl)ccc21

0.182

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccccc1OC(F)F

0.182

View
CCOc1ncccc1NC(=O)CN1C(=O)COc2ccccc21

0.181

View
O=C(CN1C(=O)COc2ccccc21)Nc1ccc(Cl)c(Cl)c1

0.181

View
C#CCNC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.181

View
COCC(C)NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.181

View
COc1cccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1

0.180

View
Cc1cccnc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.180

View
CC(=O)N1CCN(c2ccc(NC(=O)CN3C(=O)COc4ccc(Cl)cc43)cc2)CC1

0.179

View
O=C(CN1C(=O)COc2ccccc21)Nc1ccc(O)c(Cl)c1

0.178

View
Cc1cccc(Cl)c1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.177

View
O=C(COc1ccc(Cl)cc1)N1CCN(C(=O)CN2C(=O)COc3ccc(Cl)cc32)CC1

0.177

View
CCN(CC)C(=O)CN(C)C(=O)CN1C(=O)COc2ccc(Cl)cc21

0.177

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccccn1

0.177

View
Cc1cccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1

0.176

View
N#Cc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)cc1Cl

0.176

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccc(N2CCOCC2)cc1

0.176

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)NCCOc1ccccc1

0.174

View
COCCNC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.174

View
CN1CCN(C(=O)CN2C(=O)COc3ccc(Cl)cc32)CC1.Cl

0.174

View
CN1CCN(C(=O)CN2C(=O)COc3ccc(Cl)cc32)CC1

0.174

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)NCCN1CCN(c2ccccc2)CC1

0.174

View
CC(C)NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.174

View
CCOc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)cc1

0.172

View
COc1ncccc1NC(=O)CN1C(=O)COc2ccccc21

0.171

View
CCc1cccc(C)c1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.171

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)N1CCN(c2ccccc2)CC1

0.169

View
COc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)cc1

0.169

View
CC(=O)Nc1cccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1

0.168

View
CCNC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.167

View
CN(C)C(=O)CN1C(=O)COc2ccc(Cl)cc21

0.167

View
COc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)cc1Cl

0.167

View
Cc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)cc1

0.167

View
Cc1cccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1C

0.167

View
Cc1ccc(C)c(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c1

0.167

View
CCN(CC)C(=O)CN1C(=O)COc2ccc(Cl)cc21

0.167

View
CN(C)c1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)cc1

0.165

View
CNC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.165

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)NCc1ccccn1

0.163

View
CC(NC(=O)CN1C(=O)COc2ccc(Cl)cc21)c1ccncc1

0.163

View
CC(=O)Nc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)cc1

0.162

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccc(O)cc1

0.162

View
Cc1cc(C)c(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c(C)c1

0.158

View
Cc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)c(C)c1

0.158

View
CC1Oc2ccccc2N(CC(=O)Nc2cnccc2CO)C1=O

0.157

View
Cc1ccc(Cl)cc1NC(=O)CN1C(=O)COc2ccccc21

0.157

View
Cc1c(Cl)cccc1NC(=O)CN1C(=O)COc2ccccc21

0.157

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccc(Cl)cc1

0.153

View
O=C(CN1C(=O)COc2ccccc21)Nc1cnccc1O

0.153

View
COc1ccc(Cl)cc1NC(=O)CN1C(=O)COc2ccccc21

0.152

View
CCOc1ccccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.151

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cc(Cl)ccc1O

0.147

View
COc1ccccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.147

View
COc1ccc(Cl)cc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.147

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccccc1

0.147

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cccc(Cl)c1

0.147

View
CN(Cc1ccncc1)C(=O)CN1C(=O)COc2ccc(Cl)cc21

0.145

View
Cc1cc(Cl)ccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.142

View
Cc1cccc(C)c1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.140

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cn[nH]c1

0.139

View
Cc1ccccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.136

View
Cc1ccc(Cl)cc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.136

View
O=C(CN1C(=O)COc2ccccc21)Nc1cccnc1

0.134

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1ccncc1

0.122

View
COc1ccc(NC(=O)CN2C(=O)COc3ccc(Cl)cc32)cn1

0.116

View
COc1ncccc1NC(=O)CN1C(=O)COc2ccc(Cl)cc21

0.098

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cnccc1O

0.064

View
O=C(CN1C(=O)COc2ccc(Cl)cc21)Nc1cccnc1

0.043

View
C(NC1=C(C)C=CN=C1)(=O)CN1C(=O)COC2=C1C=CC=C2

0.920

View
C(NC1=CN=CC(Cl)=C1C)(=O)CN1C(=O)COC2=C1C=CC=C2

0.919

View
C(NC1=C(C)C=CN=C1)(=O)CN1C(=O)C(CC)OC2=C1C=C(C=C2)Cl

0.877

View
C(NC1=C(Cl)C=CN=C1)(=O)CN1C(=O)COC2=C1C=CC=C2

0.859

View
C(NC1=CC=CN=C1)(=O)CN1C(=O)COC2=C1C=CC=C2

0.854

View


Discussion: