Submission Details
Molecule(s):
O=C1/C(=C/c2ccc(O)cc2)c2ccccc2C(=O)N1Cc1ccc2c(c1)OCO2
CS(=O)(=O)c1oc(-c2ccc(F)cc2)nc1S(=O)(=O)c1ccc(Cl)cc1
CCOc1ccccc1/C=C1/C(=O)NC(=O)c2ccccc21
CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccccc2Cc2ccccc2)n1
CCOC(=O)c1nc(S(C)(=O)=O)ncc1Cl
COc1ccc(C(=O)Nc2cccc(/C=C3/C(=O)NC(=O)c4ccccc43)c2)cc1
Sc1nc2ccccc2c2nc(CCc3ccccc3)nn12
NC1=Nc2nc3ccccc3n2C(c2ccc(-c3nc4ccccc4s3)o2)N1
O=C(c1ccccc1)N1CCN(C(=O)c2nn(-c3ccccc3C(F)(F)F)cc2O)CC1
CCn1c(CSc2nc(C)c(C)n2CC2CCCO2)nc2cc(S(=O)(=O)N(C)C)ccc21
O=C(CSC1=NCCS1)c1cc(Cl)ccc1Cl
Design Rationale:
Enamine-available hits (>80% inhibition at 10uM) from the HTS against Mpro run at Weizmann