Submission Details
Molecule(s):
CCNc1ncc(C#N)cc1CN1CCN(C(C)=O)CC1
CC#Cc1cnc(Nc2ccccc2)c(CN2CCN(C(C)=O)CC2)c1
CC(=O)N1CCN(Cc2cc(Cl)cnc2NCCO)CC1
CCNc1ncc(C#N)cc1CN1CC2(C1)CN(C(C)=O)C2
CCNc1ncc(C#N)cc1CN1C[C@H]2CN(C(C)=O)C[C@H]2C1
CCNc1ncc(C#N)cc1CN1CCCN(C(C)=O)CC1
CCNc1ccc(C#N)cc1C(=O)N1CCN(C(C)=O)CC1
CC(=O)N1CCN(Cc2cc(C#N)ccc2NC2CC2)CC1
CC#Cc1ccc(NCC)c(CN2CCN(C(C)=O)CC2)c1
CCNc1ccc(F)cc1CN1CCN(C(C)=O)CC1
CC(=O)NCCNCc1cc(C#N)cnc1NC1CC1
CC(=O)N1CCN(Cc2cc(C#N)ccc2CNC(=O)N2CCOCC2)CC1
Design Rationale:
X0692_0 and x0305 merge perfectly. Acetylpiperazine and nitrile moieties seem to be important for binding of several fragments.