Submission Details

EDG-MED-f9979214
Molecule(s):
CS(=O)(=O)Nc1ccc2c(NC(=O)C3CCS(=O)(=O)c4ccc(Cl)cc43)cncc2c1

EDG-MED-f9979214-1

CS(=O)(=O)Nc1ccc2c(NC(=O)C3CCS(=O)(=O)c4ccc(Cl)cc43)cncc2c1

3-aminopyridine-like Ordered Check Availability on Manifold View
COc1ccc2c(NC(=O)C3CCS(=O)(=O)c4ccc(Cl)cc43)cncc2c1

EDG-MED-f9979214-2
Duplicate of:
ALP-POS-6f6ae286-7

COc1ccc2c(NC(=O)C3CCS(=O)(=O)c4ccc(Cl)cc43)cncc2c1

Duplicate 3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Analogues of EDJ-MED-b7309adf-1 which has improved rodent half life, investigate if 7-substitution is blocking metabolism but NHSO2 and OMe at 6 position increase potency.

Inspired By:
Discussion:

Contributor: Ed Griffen, MedChemica Ltd - Thu, 01 Jul 2021 09:48:35 +0000