Submission Details

CHR-SOS-f7373dd1
Molecule(s):
O=C(CC1(c2ccccc2)CCCCC1)Nc1cccnc1

CHR-SOS-f7373dd1-1

O=C(CC1(c2ccccc2)CCCCC1)Nc1cccnc1

3-aminopyridine-like Check Availability on Manifold View
O=C(CC1(c2cccnc2)CCCCC1)Nc1cccnc1

CHR-SOS-f7373dd1-2

O=C(CC1(c2cccnc2)CCCCC1)Nc1cccnc1

3-aminopyridine-like Check Availability on Manifold View
Cc1ncc(C2(CC(=O)Nc3cccnc3)CCCCC2)s1

CHR-SOS-f7373dd1-3

Cc1ncc(C2(CC(=O)Nc3cccnc3)CCCCC2)s1

3-aminopyridine-like Check Availability on Manifold View
O=C(CC1(c2ccccc2)CCCC1)Nc1cccnc1

CHR-SOS-f7373dd1-4

O=C(CC1(c2ccccc2)CCCC1)Nc1cccnc1

3-aminopyridine-like Made Check Availability on Manifold View
O=C(CC1(c2cccnc2)CCCC1)Nc1cccnc1

CHR-SOS-f7373dd1-5

O=C(CC1(c2cccnc2)CCCC1)Nc1cccnc1

3-aminopyridine-like Check Availability on Manifold View
Cc1ncc(C2(CC(=O)Nc3cccnc3)CCCC2)s1

CHR-SOS-f7373dd1-6

Cc1ncc(C2(CC(=O)Nc3cccnc3)CCCC2)s1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Structure-Based Design: - Combination X_0678 and X0946 without sulphonamide - Combination X_0678 and pyridine version X0946 without sulphonamide - Combination X_0678 and methylthiazole isostere version X0946 without sulphonamide - Combination cyclopentyl version X_0678 and X0946 without sulphonamide - Combination cyclopentyl version X_0678 and pyridine version X0946 without sulphonamide - Combination cyclopentyl version X_0678 and methylthiazole isostere version X0946 without sulfonamide

Inspired By:
Discussion:

Contributor: Chris de Graaf, Sosei Heptares - Sat, 21 Mar 2020 01:19:33 +0000