Follow-up SAR on the latest results. Strong focus on the search for the best aminopyridine mimic. N-aminoheterocycles seem to be more active than C-aminoheterocycles. Imo every heterocycle should be benchmarked on the meta-chlorophenyl acetic acid. The best one from that list should than be synthesized with all more complex substituents (b-lactam, etc...) knowing which part of the JAG-UCB hit is causing the immense increase in affinity (maybe both) is key to the design of better analogues.