Submission Details

JAG-UCB-f37eaa14
Molecule(s):
O=C1N(c2cncc3ccccc23)CC[C@]12COc1cc(F)c(Cl)cc12

JAG-UCB-f37eaa14-1

O=C1N(c2cncc3ccccc23)CC[C@]12COc1cc(F)c(Cl)cc12

3-aminopyridine-like Check Availability on Manifold View
O=C1N(c2cncc3ccccc23)CC[C@]12CNc1ccc(Cl)cc12

JAG-UCB-f37eaa14-2

O=C1N(c2cncc3ccccc23)CC[C@]12CNc1ccc(Cl)cc12

3-aminopyridine-like Check Availability on Manifold View
O=C1N(c2cncc3ccccc23)CC[C@]12COc1ccc(Cl)cc12

JAG-UCB-f37eaa14-3

O=C1N(c2cncc3ccccc23)CC[C@]12COc1ccc(Cl)cc12

3-aminopyridine-like Ordered Check Availability on Manifold View
O=C1N(c2cncc3ccccc23)CC[C@]12CN(CCNC1CC1)c1ccc(Cl)cc12

JAG-UCB-f37eaa14-4

O=C1N(c2cncc3ccccc23)CC[C@]12CN(CCNC1CC1)c1ccc(Cl)cc12

3-aminopyridine-like Check Availability on Manifold View
O=C1NCCN1CCN1C[C@]2(CCN(c3cncc4ccccc34)C2=O)c2cc(Cl)ccc21

JAG-UCB-f37eaa14-5

O=C1NCCN1CCN1C[C@]2(CCN(c3cncc4ccccc34)C2=O)c2cc(Cl)ccc21

3-aminopyridine-like Check Availability on Manifold View
O=C1C[C@@H](N2C[C@]3(CCN(c4cncc5ccccc45)C3=O)c3cc(Cl)ccc32)N1

JAG-UCB-f37eaa14-6

O=C1C[C@@H](N2C[C@]3(CCN(c4cncc5ccccc45)C3=O)c3cc(Cl)ccc32)N1

3-aminopyridine-like Check Availability on Manifold View
CC(C)[C@]1(O)C[C@@H](N2C[C@]3(CCN(c4cncc5ccccc45)C3=O)c3cc(Cl)ccc32)C1

JAG-UCB-f37eaa14-7

CC(C)[C@]1(O)C[C@@H](N2C[C@]3(CCN(c4cncc5ccccc45)C3=O)c3cc(Cl)ccc32)C1

3-aminopyridine-like Check Availability on Manifold View
O=C1N(c2cncc3ccccc23)CC[C@]12CN(CCn1ccnc1)c1ccc(Cl)cc12

JAG-UCB-f37eaa14-8

O=C1N(c2cncc3ccccc23)CC[C@]12CN(CCn1ccnc1)c1ccc(Cl)cc12

3-aminopyridine-like Check Availability on Manifold View
O=C1CC(N2C[C@]3(CCN(c4cncc5ccccc45)C3=O)c3cc(Cl)ccc32)C1

JAG-UCB-f37eaa14-9

O=C1CC(N2C[C@]3(CCN(c4cncc5ccccc45)C3=O)c3cc(Cl)ccc32)C1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Incorporate conformational constraint into benzofuran/indoline scaffold. Explore substitution off of the indoline N.

Inspired By:
Discussion:

Contributor: Jag Heer, UCB - Tue, 26 Jan 2021 12:41:54 +0000