Submission Details
Molecule(s):
CC(C)(C)OC(=O)Nc1cccn(C(c2cc(C(=O)C(=O)NCc3ccccc3)cc3[nH]cc(C=O)c23)C2CC2)c1=O
Design Rationale:
This is a more rigid version of the alpha-ketoamide inhibitor recently published in Science by the Zhang and Hilgenfeld team at DZIF in Germany. The central peptide connection has been replaced by a carboxy indole group which may provide an alternative synthesis.
Other Notes:
Attribution of the inspirational structure: L. Zhang et al., Science 10.1126/science.abb3405 (2020).