Submission Details

ALP-POS-f1807566
Molecule(s):
O=C1NCC(C(=O)Nc2cncc3ccccc23)c2cc(F)cc(F)c21

ALP-POS-f1807566-1

O=C1NCC(C(=O)Nc2cncc3ccccc23)c2cc(F)cc(F)c21

3-aminopyridine-like Assayed Check Availability on Manifold View
COc1ccc2cncc(NC(=O)C3CNC(=O)c4ccc(Cl)cc43)c2c1

ALP-POS-f1807566-2

COc1ccc2cncc(NC(=O)C3CNC(=O)c4ccc(Cl)cc43)c2c1

3-aminopyridine-like Check Availability on Manifold View
COC1(C(=O)Nc2cncc3ccccc23)CNC(=O)c2ccc(Cl)cc21

ALP-POS-f1807566-3

COC1(C(=O)Nc2cncc3ccccc23)CNC(=O)c2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Expanding on MIC-UNK-91acba05-1, making changes that improves metabolic stability and potency.

Discussion:

Contributor: Alpha Lee, PostEra - Tue, 25 May 2021 08:44:05 +0000