Submission Details
Molecule(s):
Cc1cccc([C@H](c2cccc(Cl)c2)N2CC3CC2CN3C(=O)CCl)c1
O=C(CCl)N1CC2CC1CN2Cc1ncc(Cc2ccccc2)s1
O=C(CCl)N1CC2CC1CN2C1(c2cccc(Cl)c2)CCO1
O=C(CCl)N1CC2CC1CN2C1(c2cccc(Cl)c2)CC1
O=C(Nc1ccccc1OC1CCN(Cc2ccccc2)CC1)C1CC2CC1CN2C(=O)CCl
O=C(CCl)N1CC2CC1CN2[C@H](c1ccc(Cl)cc1)c1cccc(Cl)c1
Nc1nc(CN2CC3CC2CN3C(=O)CCl)ncc1Cc1ccccc1
CC(=O)NCCc1c[nH]c2c(C(c3ccccc3)N3CC4CC3CN4C(=O)CCl)cccc12
Cc1ccc(C(c2cccc(C)c2)N2CC3CC2CN3C(=O)CCl)cc1
CCNc1cccc(C#N)c1CN1CC2CC1CN2C(=O)CCl
O=C(CCl)N1CC2CC1CN2Cc1cnc(Cc2ccccc2)s1
NC(=O)C1CC2(CC3CC2N(C(=O)CCl)C3)CC1c1ccccc1
O=C(CCl)N1CC2CC1CN2C(F)(F)c1cccc(Cl)c1
COCc1cc(Cl)cc(CN2CC3CC2CN3C(=O)CCl)c1
CCNc1ncc(C#N)cc1C(c1cccc(Cl)c1)N1CC2CC1CN2C(=O)CCl
N#Cc1cnc(CCO)cc1CN1CC2CC1CN2C(=O)CCl
COCCc1ccc(Cl)cc1CN1CC2CC1CN2C(=O)CCl
CC1C2CC(CN2C(=O)CCl)N1C(F)(F)c1cccc(Cl)c1
O=C(NCCN1CC2CC1CN2C(=O)CCl)c1cccc2ccccc12
O=C(NCCN1CC2CC1CN2C(=O)CCl)c1cccnc1
CCNc1ccc(C#N)cc1CN1CC2CC1CN2C(=O)CCl
CCNc1ncc(C#N)cc1CN1CC2CC1CN2C(=O)CCl
CCNc1ncc(OC)cc1CN1CC2CC1CN2C(=O)CCl
COc1cc(CN2CC3CC2CN3C(=O)CCl)c2ccccc2c1
N#Cc1ccc(CNC(=O)N2CCOCC2)c(CN2CC3CC2CN3C(=O)CCl)c1
O=C(CCl)N1C2CC(c3ccccc3)(c3ccccc32)C1Cc1cccnc1
NS(=O)(=O)C1CCc2cc(C34CC(c5ccccc53)N(C(=O)CCl)C4)ccc2C1
CC(=O)NCCC1C=Nc2c(CN3CC4CC3CN4C(=O)CCl)cc(F)cc21
CC(=O)N1C2CC([C@@H]1CC(N)=O)N(C(=O)CCl)C2
CC(=O)N1[C@@H](CC(N)=O)C2C[C@]1(C(C)=O)CN2C(=O)CCl
CC(=O)[C@@H]1C2C[C@@](CC(N)=O)(CN2C(=O)CCl)N1C(C)=O
Cc1cccc(NC2CC3CC2CN3C(=O)CCl)c1
CC(=O)NCCc1c[nH]c2c(CC3CC4CC3CN4C(=O)CCl)cc(F)cc12
CC(=O)NCCc1c[nH]c2c(NC3CC4CC3CN4C(=O)CCl)cc(F)cc12
NS(=O)(=O)c1ccc2ccc(CC3CC4CC3CN4C(=O)CCl)cc2c1
NS(=O)(=O)c1ccc2ccc(NC3CC4CC3CN4C(=O)CCl)cc2c1
CCNc1ncc(C#N)cc1CC1CC2CC1CN2C(=O)CCl
Cc1cc(Cl)cc(CC2CC3CC2CN3C(=O)CCl)c1
Nc1cccc(C23CC(c4ccccc42)N(C(=O)CCl)C3)c1
N#Cc1cccc(C23CC(c4ccccc42)N(C(=O)CCl)C3)c1
CC(=O)NCCc1c[nH]c2c(C34CC(c5ccccc53)N(C(=O)CCl)C4)c(F)ccc12
Cc1cccc(C23CC(c4ccccc42)N(C(=O)CCl)C3)c1
Cc1cc(C)nc(NC2CC3CC2CN3C(=O)CCl)n1
NC(=O)C1C2CC(CN2C(=O)CCl)N1Cc1cccc(Cl)c1
CC(C)C[C@@H]1C2CC(CN2C(=O)CCl)N1Cc1cccc(Cl)c1
O=C(CCl)N1C2CC([C@@H]1Cc1ccccc1)N(Cc1cccc(Cl)c1)C2
CC(=O)NCCc1c[nH]c2c(CN3CC4CC3CN4C(=O)CCl)cccc12
CS(=O)(=O)N(CCc1ccccc1)CC1CC2CC1CN2C(=O)CCl
O=C(CCl)N1CC2CC1CN2C(CCc1ccccc1)c1cccc(Cl)c1
Cc1ccc(CCC(c2cccc(Cl)c2)N2CC3CC2CN3C(=O)CCl)cc1
N#Cc1cccc(C(CCc2ccccc2)N2CC3CC2CN3C(=O)CCl)c1
N#Cc1cccc(C(CCc2ccc(C(F)(F)F)cc2)N2CC3CC2CN3C(=O)CCl)c1
Cc1ccc(CCC(c2cccc(C#N)c2)N2CC3CC2CN3C(=O)CCl)cc1
CC(=O)NCCc1c[nH]c2c(C(CCc3ccccc3)N3CC4CC3CN4C(=O)CCl)cccc12
CC(=O)NCCc1c[nH]c2c(C(CCc3ccc(C)cc3)N3CC4CC3CN4C(=O)CCl)cccc12
CC(=O)NCCc1c[nH]c2c(C(CCc3ccc(C(F)(F)F)cc3)N3CC4CC3CN4C(=O)CCl)cccc12
COc1ccc(-n2cc(CN3CC4CC3CN4C(=O)CCl)nn2)cc1
O=C([C@H]1C2CC([C@@H]1CCc1ccccc1)N(C(=O)CCl)C2)N1CCCCC1
Design Rationale:
ordered chloroacetamides modified by adding an extra C atom above a piperidine or piperazine ring (similar to x0770 transformed into x3077)