COC1(C(=O)Nc2cncc3ccccc23)CCS(=O)(=O)c2ccc(Cl)cc21
MIC-UNK-ea4eb352-2
Duplicate of:
ALP-POS-5290f14d-1
COC1(C(=O)Nc2cncc3ccccc23)CN(S(C)(=O)=O)Cc2ccc(Cl)cc21
COC1(C(=O)Nc2cncc3ccccc23)CCNc2ccc(Cl)cc21
COC1(C(=O)Nc2cncc3ccccc23)CCSc2ccc(Cl)cc21
COC1(C(=O)Nc2cncc3ccccc23)CCS(=O)(=O)c2cc(Cl)c(Cl)cc21
COC1(C(=O)Nc2cncc3ccccc23)CN(S(C)(=O)=O)Cc2cc(Cl)c(Cl)cc21
MIC-UNK-ea4eb352-7
Duplicate of:
EDJ-MED-4f704dc9-1
COC1(C(=O)Nc2cncc3ccccc23)CCNc2cc(Cl)c(Cl)cc21
COC1(C(=O)Nc2cncc3ccccc23)CCSc2cc(Cl)c(Cl)cc21
COC1(C(=O)Nc2cncc3ccccc23)CCS(=O)(=O)c2cc(F)c(Cl)cc21
COC1(C(=O)Nc2cncc3ccccc23)CN(S(C)(=O)=O)Cc2cc(F)c(Cl)cc21
MIC-UNK-ea4eb352-11
Duplicate of:
ALP-POS-fe871b40-12
COC1(C(=O)Nc2cncc3ccccc23)CCNc2cc(F)c(Cl)cc21
COC1(C(=O)Nc2cncc3ccccc23)CCSc2cc(F)c(Cl)cc21
I've picked six-membered ring systems that replacing chromane increase potency, then added methoxy, second chlorine or fluorine. Some of these were submitted previously