Submission Details

Molecule(s):
NS(=O)(=O)c1cccc(C2(CC(=O)Nc3cccnc3)CCCCC2)c1

CHR-SOS-e960e883-1

NS(=O)(=O)c1cccc(C2(CC(=O)Nc3cccnc3)CCCCC2)c1

3-aminopyridine-like Check Availability on Manifold View
NS(=O)(=O)c1cccc(C2(CC(=O)Nc3cccnc3)CCCC2)c1

CHR-SOS-e960e883-2

NS(=O)(=O)c1cccc(C2(CC(=O)Nc3cccnc3)CCCC2)c1

3-aminopyridine-like Check Availability on Manifold View
NS(=O)(=O)c1cccc(C2(CC(=O)Nc3cccnc3)CCC2)c1

CHR-SOS-e960e883-3

NS(=O)(=O)c1cccc(C2(CC(=O)Nc3cccnc3)CCC2)c1

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1NC(=O)CC1(c2cccc(S(N)(=O)=O)c2)CCCCC1

CHR-SOS-e960e883-4

Cc1ccncc1NC(=O)CC1(c2cccc(S(N)(=O)=O)c2)CCCCC1

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1NC(=O)CC1(c2cccc(S(N)(=O)=O)c2)CCCC1

CHR-SOS-e960e883-5

Cc1ccncc1NC(=O)CC1(c2cccc(S(N)(=O)=O)c2)CCCC1

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1NC(=O)CC1(c2cccc(S(N)(=O)=O)c2)CCC1

CHR-SOS-e960e883-6

Cc1ccncc1NC(=O)CC1(c2cccc(S(N)(=O)=O)c2)CCC1

3-aminopyridine-like Check Availability on Manifold View

Design Rationale:

Structure-Based Design: - Combination of X_0678 and X_0946 - Combination of cyclopentyl version of X_0678 and X_0946 - Combination of cyclobutyl version of X_0678 and X_0946 - Combination of X_0678 and X_0946 with methyl substitution to lock pyridine conformation - Combination of cyclopentyl version of X_0678 and X_0946 with methyl substitution to lock pyridine conformation - Combination of cyclobutyl version of X_0678 and X_0946 with methyl substitution to lock pyridine conformation

Inspired By:
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Discussion: