Submission Details
Molecule(s):
O=C(Cl)CN1CCN(S(=O)(=O)C2=CC(F)=C3C=CC=[SH]3=C2)CC1
Design Rationale:
I was looking at the LON-WEI-8f408cad-4 as well as the MAK-UNK-d4768348-1 compounds and saw that there was a lower IC50 in the second compound mentioned than in the first one. I was thinking that maybe adding the benzene at the end and another halide may be helpful when interacting with the SARS CoV2 main protease. I wanted to create a structure in the same series as the LON-WEI-8f408cad-4 with the sulfone, acid halide and the ring with the nitrogens combining the two may be better.