C[C@@]1(C(=O)Nc2cncc3ccccc23)C(=O)COc2ccc(Cl)cc21
C[C@@H]1C[C@@H](C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2O1
C[C@H]1C[C@@H](C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2O1
O=C(Nc1cncc2ccccc12)[C@@H]1CCOc2c(OC3COC3)cc(Cl)cc21
O=C(Nc1cncc2ccccc12)[C@@H]1CCOc2c(C3COC3)cc(Cl)cc21
CCC[C@H]1COc2ccc(Cl)cc2[C@@H]1C(=O)Nc1cncc2ccccc12
COc1cc(Cl)cc2c1OCC[C@H]2C(=O)Nc1cncc2ccccc12
Cc1c(Cl)ccc2c1[C@H](C(=O)Nc1cncc3ccccc13)CCO2
O=C(Nc1cncc2ccccc12)[C@@H]1CCOc2ccc(Cl)nc21
O=C(Nc1cncc2ccccc12)[C@@H]1CCOc2ccc(Cl)c(Cl)c21
C[C@H]1COc2ccc(Cl)cc2[C@@H]1C(=O)Nc1cncc2ccccc12
O=C(Nc1cncc2ccccc12)[C@@H]1COc2ccc(Cl)cc2C1
C[C@@]1(C(=O)Nc2cncc3ccccc23)CCOc2ccc(Cl)cc21
Follow ups to VLA-UCB-1dbca3b4-15 using MPro-x10942 as structural guidance. Stereochemistry is preferred. Key goal is to bias amide into axial position conformation and add small substituents to increase potency. Many of these designs are built from those developed for JAG-UCB-a3ef7265-20. So additional inspirations include: VLA-UCB-1dbca3b4-14 MIK-NEW-7f99bfc4-1 BAR-COM-ace1b61b-3 BAR-COM-ace1b61b-2 BAR-COM-ace1b61b-1 JAN-GHE-299e5c7e-4 MAT-POS-e478a234-1 RAL-THA-f8a0f917-3 RAL-THA-f8a0f917-2 RAL-THA-f8a0f917-1 EDG-MED-4b32601a-1 EDG-MED-fe7487f8-2 NAU-LAT-8502cac5-3