Submission Details

ALP-POS-e266d783
Molecule(s):
CNC(=O)CN1CC(C)(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O

ALP-POS-e266d783-1

CNC(=O)CN1CC(C)(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2C1=O

CNC(=O)CN1Cc2ccc(Cl)cc2C(C)(C(=O)Nc2cncc3ccccc23)C1

ALP-POS-e266d783-2
Duplicate of:
MAT-POS-89bd6af1-3

CNC(=O)CN1Cc2ccc(Cl)cc2C(C)(C(=O)Nc2cncc3ccccc23)C1

Duplicate 3-aminopyridine-like Ordered Check Availability on Manifold View
Design Rationale:

increase log P slightly to fix permeability. Also to prevent racemisation.

Discussion:

Contributor: Alpha Lee, PostEra - Thu, 26 Aug 2021 13:55:12 +0000