Submission Details

RAV-REL-e0cd5b56
Molecule(s):
C=CC(=O)N1Cc2ccc(C(F)(F)F)cc2C(c2ccccc2Cl)C1

RAV-REL-e0cd5b56-1

C=CC(=O)N1Cc2ccc(C(F)(F)F)cc2C(c2ccccc2Cl)C1

C=C(C)C(=O)N1Cc2ccc(C(F)(F)F)cc2C(c2ccccc2Cl)C1

RAV-REL-e0cd5b56-2

C=C(C)C(=O)N1Cc2ccc(C(F)(F)F)cc2C(c2ccccc2Cl)C1

C=CC(=O)N1Cc2ccc(C(F)(F)F)cc2C(c2ccc(C(C)(C)O)cc2Cl)C1

RAV-REL-e0cd5b56-3

C=CC(=O)N1Cc2ccc(C(F)(F)F)cc2C(c2ccc(C(C)(C)O)cc2Cl)C1

Design Rationale:

Hello Team, please take a look at the following 3 structures that are attempting to engage Cys 145 via the acyl-dihydroisoquinoline and related hits in cluster-2. Thank you for this incredible effort to help humanity at their of hour of need. Ravi Kurukulasuriya Relay Chemistry

Inspired By:
Discussion:

Contributor: Ravi Kurukulasuriya, Relay Therapeutics - Cambridge MA- USA - Mon, 23 Mar 2020 18:20:40 +0000