Submission Details

Molecule(s):
CC(=O)NCCc1c[nH]c2c(CCNS(C)(=O)=O)cc(F)cc12

ELE-IMP-dfb36048-1

CC(=O)NCCc1c[nH]c2c(CCNS(C)(=O)=O)cc(F)cc12

CC(=O)NCCc1c[nH]c2c(CCNS(C)(=O)=O)cccc12

ELE-IMP-dfb36048-2

CC(=O)NCCc1c[nH]c2c(CCNS(C)(=O)=O)cccc12

CC(=O)N1CCc2c([nH]c3c(CCNS(C)(=O)=O)cccc23)C1

ELE-IMP-dfb36048-3

CC(=O)N1CCc2c([nH]c3c(CCNS(C)(=O)=O)cccc23)C1

CS(=O)(=O)NCCc1cccc2c3c([nH]c12)CN(S(C)(=O)=O)CC3

ELE-IMP-dfb36048-4

CS(=O)(=O)NCCc1cccc2c3c([nH]c12)CN(S(C)(=O)=O)CC3

CS(=O)(=O)NCCc1c[nH]c2c(CCNS(C)(=O)=O)cccc12

ELE-IMP-dfb36048-5

CS(=O)(=O)NCCc1c[nH]c2c(CCNS(C)(=O)=O)cccc12


Design Rationale:

Merging by eye of non-covalent fragments evolved with rational design to reduce flexibility.

Inspired By:
Discussion: