Submission Details
Molecule(s):
O=C(CCl)Nc1nc2c(C(=O)NCCc3cccc(F)c3)cccc2s1
Cc1cccc(C(c2ccc(C)s2)N2CCN(C(=O)CCl)CC2)c1
Design Rationale:
This time I looked at both covalent and noncovalent hits, and I began with 1348 and used an amide bond to link to 0072 (but with a fluorine like 1382. I also created another derivative using 692 and 1334, they had a similar scaffold, but branched to two areas of the pocket.