Submission Details
Molecule(s):
O=C(C#Cc1ccc(CNC(=O)N2CCOCC2)cc1)NCc1ccccc1
O=C(C#Cc1ccc(CNC(=O)N2CCOCC2)cc1)NCc1ccc(C(F)(F)F)cc1
CN(Cc1ccccc1)C(=O)C#Cc1ccc(CNC(=O)N2CCOCC2)cc1
O=C(NCc1ccc(C#Cc2ccccc2)cc1)N1CCOCC1
Cc1cccc(C#Cc2ccc(CNC(=O)N3CCOCC3)cc2)c1
O=C(NCc1ccc(C#Cc2cccc(CCO)c2)cc1)N1CCOCC1
O=C(NCc1ccc(C#Cc2ccccc2CO)cc1)N1CCOCC1
Design Rationale:
building out from hits PAT-GYR-359-3. into new pocket. Synthetically facile from previous hits