Submission Details
Molecule(s):
O=C(Nc1cncc2ccccc12)C1(OCC(F)(F)F)CCOc2ccc(Cl)cc21
O=C(Nc1cncc2ccccc12)C1(OCCOC(F)(F)F)CCOc2ccc(Cl)cc21
O=C(Nc1cncc2ccccc12)C1(OCCC(F)(F)F)CCOc2ccc(Cl)cc21
Design Rationale:
I've put what I guess would be reasonably metabolically stable groups that could go into P1' pocket on generic chromane scaffold and also what I hope could be synthetisable from ethylene oxide adduct mentioned by @edgriffen, first by oxidation, then decarboxylative trifluoromethylation, third by OH -> Br -> CF3 sequence, both copper-catalyzed radical processes