Submission Details

EDJ-MED-dd2a8363
Molecule(s):
O=C1NCC(C(=O)Nc2cnn3ccccc23)c2cc(Cl)ccc21

EDJ-MED-dd2a8363-1

O=C1NCC(C(=O)Nc2cnn3ccccc23)c2cc(Cl)ccc21

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C(Nc1cnn2ccccc12)C1CCS(=O)(=O)c2ccc(Cl)cc21

EDJ-MED-dd2a8363-2

O=C(Nc1cnn2ccccc12)C1CCS(=O)(=O)c2ccc(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
O=C1NCC(C(=O)Nc2cnn3c2CCCC3)c2cc(Cl)ccc21

EDJ-MED-dd2a8363-3

O=C1NCC(C(=O)Nc2cnn3c2CCCC3)c2cc(Cl)ccc21

3-aminopyridine-like Assayed Check Availability on Manifold View
Cc1cccn2ncc(NC(=O)C3CNC(=O)c4ccc(Cl)cc43)c12

EDJ-MED-dd2a8363-4

Cc1cccn2ncc(NC(=O)C3CNC(=O)c4ccc(Cl)cc43)c12

3-aminopyridine-like Assayed Check Availability on Manifold View
COc1ccn2ncc(NC(=O)C3CNC(=O)c4ccc(Cl)cc43)c2c1

EDJ-MED-dd2a8363-5

COc1ccn2ncc(NC(=O)C3CNC(=O)c4ccc(Cl)cc43)c2c1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

JIN-POS-6dc588a4-9 shows enhanced metabolic stability as measured by iv cassette dosing with opportunity to increase potency by substitution. Generate analogues with higher potency P2 groups and substituted pyrazolopyridines.

Inspired By:
Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Thu, 24 Jun 2021 19:51:47 +0000