Submission Details

GAB-FAC-da17721d
Molecule(s):
CCCCOc1ccc(NC(=O)Nc2ncc([N+](=O)[O-])s2)cc1

GAB-FAC-da17721d-1

CCCCOc1ccc(NC(=O)Nc2ncc([N+](=O)[O-])s2)cc1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Compound is an analogue of nitazoxanide, a broad spectrum amtimicrobial drug. Nitazoxanide has been tested agains COVID2019 and showed potency in the low micromolar range EC50= 2.12 microMolar. I think it is a good lead

Other Notes:

This compound and some other ureas are prepared in a one step route in my medchem lab. we designed these molecules as broad antiprotozoal drugs with nanomolar potencies, and also showed antimycobacterial effect

Inspired By:
Discussion:

Contributor: Gabriel Navarrete-Vazquez, Facultad de Farmacia, Universidad AUtonoma del estado de Morelos, Mexico - Mon, 23 Mar 2020 14:20:33 +0000