Submission Details

MAK-UNK-d508046f
Molecule(s):
CC(CNCC1CCCO1)OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

MAK-UNK-d508046f-1

CC(CNCC1CCCO1)OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

3-aminopyridine-like Check Availability on Manifold View
CC(CNCCCO)OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

MAK-UNK-d508046f-2

CC(CNCCCO)OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

3-aminopyridine-like Check Availability on Manifold View
COC1CCN(C(C)COCCN(C(=O)C2CCSc3ccc(Cl)cc32)c2cccnc2)CC1

MAK-UNK-d508046f-3

COC1CCN(C(C)COCCN(C(=O)C2CCSc3ccc(Cl)cc32)c2cccnc2)CC1

3-aminopyridine-like Check Availability on Manifold View
CC(CSC1CCOC1C)OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

MAK-UNK-d508046f-4

CC(CSC1CCOC1C)OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

3-aminopyridine-like Check Availability on Manifold View
CC(CSC1CCCC1)OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

MAK-UNK-d508046f-5

CC(CSC1CCCC1)OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

3-aminopyridine-like Check Availability on Manifold View
CN(C)C(OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1)C1CCC1

MAK-UNK-d508046f-6

CN(C)C(OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1)C1CCC1

3-aminopyridine-like Check Availability on Manifold View
CNC(COC(C)C)OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

MAK-UNK-d508046f-7

CNC(COC(C)C)OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

3-aminopyridine-like Check Availability on Manifold View
O=C(C1CCSc2ccc(Cl)cc21)N(CCOCCOC1CNC1)c1cccnc1

MAK-UNK-d508046f-8

O=C(C1CCSc2ccc(Cl)cc21)N(CCOCCOC1CNC1)c1cccnc1

3-aminopyridine-like Check Availability on Manifold View
CC1(COCCN(C(=O)C2CCSc3ccc(Cl)cc32)c2cccnc2)CC1(F)F

MAK-UNK-d508046f-9

CC1(COCCN(C(=O)C2CCSc3ccc(Cl)cc32)c2cccnc2)CC1(F)F

3-aminopyridine-like Check Availability on Manifold View
O=C(C1CCSc2ccc(Cl)cc21)N(CCOC1CNc2ccccc21)c1cccnc1

MAK-UNK-d508046f-10

O=C(C1CCSc2ccc(Cl)cc21)N(CCOC1CNc2ccccc21)c1cccnc1

3-aminopyridine-like Check Availability on Manifold View
CCC(C)(CC(F)F)OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

MAK-UNK-d508046f-11

CCC(C)(CC(F)F)OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

3-aminopyridine-like Check Availability on Manifold View
CC(C)CCC1(OCCN(C(=O)C2CCSc3ccc(Cl)cc32)c2cccnc2)CCCOC1

MAK-UNK-d508046f-12

CC(C)CCC1(OCCN(C(=O)C2CCSc3ccc(Cl)cc32)c2cccnc2)CCCOC1

3-aminopyridine-like Check Availability on Manifold View
O=C(C1CCSc2ccc(Cl)cc21)N(CCOC1CCNCC1)c1cccnc1

MAK-UNK-d508046f-13

O=C(C1CCSc2ccc(Cl)cc21)N(CCOC1CCNCC1)c1cccnc1

3-aminopyridine-like Check Availability on Manifold View
O=C(C1CCSc2ccc(Cl)cc21)N(CCOC1CCOCC1)c1cccnc1

MAK-UNK-d508046f-14

O=C(C1CCSc2ccc(Cl)cc21)N(CCOC1CCOCC1)c1cccnc1

3-aminopyridine-like Check Availability on Manifold View
CCCC(OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1)C1CCC1

MAK-UNK-d508046f-15

CCCC(OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1)C1CCC1

3-aminopyridine-like Check Availability on Manifold View
NC(OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1)C1CC1

MAK-UNK-d508046f-16

NC(OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1)C1CC1

3-aminopyridine-like Check Availability on Manifold View
CC(C)OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

MAK-UNK-d508046f-17

CC(C)OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

3-aminopyridine-like Check Availability on Manifold View
CC(C)SCOCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

MAK-UNK-d508046f-18

CC(C)SCOCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

3-aminopyridine-like Check Availability on Manifold View
O=C(C1CCSc2ccc(Cl)cc21)N(CCOC1C=CCC1)c1cccnc1

MAK-UNK-d508046f-19

O=C(C1CCSc2ccc(Cl)cc21)N(CCOC1C=CCC1)c1cccnc1

3-aminopyridine-like Check Availability on Manifold View
CC(NC1COCC1O)OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

MAK-UNK-d508046f-20

CC(NC1COCC1O)OCCN(C(=O)C1CCSc2ccc(Cl)cc21)c1cccnc1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

O --> S, then fragment growing

Inspired By:
Discussion:

Contributor: Maksym Voznyy - Thu, 29 Oct 2020 22:57:35 +0000