Submission Details

EDJ-MED-d4864bdc
Molecule(s):
CNC(=O)C1(N2Cc3ccc(Cl)cc3C3(CCN(c4cncc5c4CCCC5)C3=O)C2)CC1

EDJ-MED-d4864bdc-1

CNC(=O)C1(N2Cc3ccc(Cl)cc3C3(CCN(c4cncc5c4CCCC5)C3=O)C2)CC1

3-aminopyridine-like Check Availability on Manifold View
CNC(=O)C1(N2CC3(CCN(c4cncc5c4CCCC5)C3=O)c3cc(Cl)ccc3C2=O)CC1

EDJ-MED-d4864bdc-2

CNC(=O)C1(N2CC3(CCN(c4cncc5c4CCCC5)C3=O)c3cc(Cl)ccc3C2=O)CC1

O=C1N(c2cncc3ccccc23)CCC12CCS(=O)(=O)c1ccc(Cl)cc12

EDJ-MED-d4864bdc-3
Duplicate of:
ALP-POS-41e2080f-1

O=C1N(c2cncc3ccccc23)CCC12CCS(=O)(=O)c1ccc(Cl)cc12

Duplicate 3-aminopyridine-like Check Availability on Manifold View
CN(C)CCOc1ccc2cncc(N3CCC4(CCS(=O)(=O)c5ccc(Cl)cc54)C3=O)c2c1

EDJ-MED-d4864bdc-4

CN(C)CCOc1ccc2cncc(N3CCC4(CCS(=O)(=O)c5ccc(Cl)cc54)C3=O)c2c1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Cyclohexylpyridines and cyclic sulphones for decreased metabolic clearence.

Discussion:

Contributor: Ed J Griffen, MedChemica Consultancy Ltd - Mon, 20 Dec 2021 17:41:04 +0000