Submission Details

PAU-WIS-d4065696
Molecule(s):
C=CC(=O)N(C(=O)[C@@H]1CCOc2ccc(Cl)cc21)c1nncn1C1CC1

PAU-WIS-d4065696-1

C=CC(=O)N(C(=O)[C@@H]1CCOc2ccc(Cl)cc21)c1nncn1C1CC1

3-aminopyridine-like Check Availability on Manifold View
CC#CC(=O)N(C(=O)[C@@H]1CCOc2ccc(Cl)cc21)c1nncn1C1CC1

PAU-WIS-d4065696-2

CC#CC(=O)N(C(=O)[C@@H]1CCOc2ccc(Cl)cc21)c1nncn1C1CC1

3-aminopyridine-like Check Availability on Manifold View
C=CC(=O)N[C@@]1(C(=O)Nc2nncn2C2CC2)CCOc2ccc(Cl)cc21

PAU-WIS-d4065696-3

C=CC(=O)N[C@@]1(C(=O)Nc2nncn2C2CC2)CCOc2ccc(Cl)cc21

Design Rationale:

Trying to find a way towards the Cysteine by eye by overlay with covalent Ugi compounds.

Other Notes:

Imides may have accessibility/stability issues.

Inspired By:
Discussion:

Contributor: Paul Gehrtz, WIS - Tue, 23 Jun 2020 07:45:02 +0000