Submission Details

DAV-CRI-d1e0885a
Molecule(s):
N#Cc1ccsc1CN1CCN(C(=O)CCl)CC1

DAV-CRI-d1e0885a-1

N#Cc1ccsc1CN1CCN(C(=O)CCl)CC1

piperazine-chloroacetamide Check Availability on Manifold View
CCNc1cc(CN2CCN(C(=O)CCl)CC2)c(C#N)cn1

DAV-CRI-d1e0885a-2

CCNc1cc(CN2CCN(C(=O)CCl)CC2)c(C#N)cn1

piperazine-chloroacetamide Check Availability on Manifold View
N#Cc1cnc(NCO)cc1CN1CCN(C(=O)CCl)CC1

DAV-CRI-d1e0885a-3

N#Cc1cnc(NCO)cc1CN1CCN(C(=O)CCl)CC1

piperazine-chloroacetamide Check Availability on Manifold View
CCNc1scc(C#N)c1CN1CCN(C(=O)CCl)CC1

DAV-CRI-d1e0885a-4

CCNc1scc(C#N)c1CN1CCN(C(=O)CCl)CC1

piperazine-chloroacetamide Check Availability on Manifold View
N#Cc1csc(NCO)c1CN1CCN(C(=O)CCl)CC1

DAV-CRI-d1e0885a-5

N#Cc1csc(NCO)c1CN1CCN(C(=O)CCl)CC1

piperazine-chloroacetamide Check Availability on Manifold View
CC(=O)Nc1scc(C#N)c1CN1CCN(C(=O)CCl)CC1

DAV-CRI-d1e0885a-6

CC(=O)Nc1scc(C#N)c1CN1CCN(C(=O)CCl)CC1

piperazine-chloroacetamide Check Availability on Manifold View
Design Rationale:

by eye linking of X0305 with X1418 or X1386, retaining covalent warhead, with variants.

Inspired By:
Discussion:

Contributor: David Briggs, Crick Institute - Thu, 26 Mar 2020 15:01:23 +0000