Submission Details
Molecule(s):
O=C(Sc1cncc(Br)c1)c1ccccc1
O=C(Sc1cncc(F)c1)c1ccccc1
O=C(Oc1cncc(Br)c1)c1ccccc1P
NNc1cccc(C(=O)Oc2cncc(Br)c2)c1
NNc1cccc(C(=O)Oc2cncc(F)c2)c1
Nc1cc2cccc(C(=O)Sc3cncc(F)c3)c2c(O)n1
Nc1cc2cccc(C(=O)Sc3cncc(Br)c3)c2c(N)n1
NC(N)(O)c1cccc(C(=O)Oc2cncc(Br)c2)c1
NC(N)(O)c1cccc(C(=O)Oc2cncc(F)c2)c1
NC(=O)Oc1c(Br)cccc1C(=O)Sc1cncc(Br)c1
NNNS(=O)(=O)c1cccc(C(=O)Oc2cncc(Br)c2)c1
O=C(CF)Oc1cncc(Br)c1
O=S(=O)(COc1cncc(Br)c1)NP
O=C(c1c(F)cccc1P)c1c(P)cccc1P
Design Rationale:
Functional similarity to current lead, spread out over range of pharmacological properties.