Submission Details

EDJ-MED-cf877e1d
Molecule(s):
CN(C)S(=O)(=O)N1Cc2cc(F)c(Cl)cc2C(C(=O)Nc2cncc3ccccc23)C1

EDJ-MED-cf877e1d-1

CN(C)S(=O)(=O)N1Cc2cc(F)c(Cl)cc2C(C(=O)Nc2cncc3ccccc23)C1

3-aminopyridine-like Check Availability on Manifold View
COC1(C(=O)Nc2cncc3ccccc23)CN(S(=O)(=O)N(C)C)Cc2ccc(Cl)cc21

EDJ-MED-cf877e1d-2

COC1(C(=O)Nc2cncc3ccccc23)CN(S(=O)(=O)N(C)C)Cc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Additional potency on MAT-POS-4223bc15-2 by addition of extra F and extra OMe. But not both.

Inspired By:
Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Wed, 28 Apr 2021 10:34:21 +0000