Submission Details
Molecule(s):
O=C(Cc1cc(Cl)cc(OC2CCN2)c1)Nc1cncc2ccccc12
Design Rationale:
This is an azetidine analog of (IC50 in fluorescence assay = 0.27 µM) in which the beta-lactam carbonyl (which may be a liability for affinity)) of ALP-POS-3b848b35-2 has been substituted for methylene. The proximity of the amine nitrogen to the linking oxygen means that the compound will be predominantly neutral at neutral pH.
Other Notes:
This compound may be accessible through reduction of the beta lactam of ALP-POS-3b848b35-2.