Submission Details

JAG-UCB-cedd89ab
Molecule(s):
Cc1ccncc1N1CCN(c2cccc(Cl)c2)C1=O

JAG-UCB-cedd89ab-1

Cc1ccncc1N1CCN(c2cccc(Cl)c2)C1=O

3-aminopyridine-like Assayed Check Availability on Manifold View
O[C@H](Cc1cccc(Cl)c1)Cn1cncn1

JAG-UCB-cedd89ab-2

O[C@H](Cc1cccc(Cl)c1)Cn1cncn1

O=C(Cc1cc(Cl)cc(Cl)c1)Nc1nncs1

JAG-UCB-cedd89ab-3

O=C(Cc1cc(Cl)cc(Cl)c1)Nc1nncs1

3-aminopyridine-like Made Check Availability on Manifold View
O=C(Cc1cccnc1)N1CCC[C@H]1c1noc(C2CC2)n1

JAG-UCB-cedd89ab-4

O=C(Cc1cccnc1)N1CCC[C@H]1c1noc(C2CC2)n1

Cc1cccc([C@H](C)C(=O)Nc2ccn[nH]2)c1

JAG-UCB-cedd89ab-5

Cc1cccc([C@H](C)C(=O)Nc2ccn[nH]2)c1

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cccc(Cl)c1)Nc1ncnc2[nH]ncc12

JAG-UCB-cedd89ab-6

O=C(Nc1cccc(Cl)c1)Nc1ncnc2[nH]ncc12

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cccc(Cl)c1)Nc1nccc2[nH]ncc12

JAG-UCB-cedd89ab-7

O=C(Nc1cccc(Cl)c1)Nc1nccc2[nH]ncc12

3-aminopyridine-like Check Availability on Manifold View
Cc1ccncc1NC(=O)Nc1cccc(Cl)c1

JAG-UCB-cedd89ab-8
Duplicate of:
TRY-UNI-714a760b-12

Cc1ccncc1NC(=O)Nc1cccc(Cl)c1

Duplicate 3-aminopyridine-like Assayed Check Availability on Manifold View
Nc1ncc(CC(=O)Nc2cc(F)ccc2F)s1

JAG-UCB-cedd89ab-9

Nc1ncc(CC(=O)Nc2cc(F)ccc2F)s1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

Chembl/SureChembl pharmacophore screen for compounds matching pharmacophore of amino pyridine series

Other Notes:

Based on amino pyridine hits

Inspired By:
Discussion:

Contributor: Jag Heer, UCB - Fri, 15 May 2020 13:45:23 +0000