Submission Details
Molecule(s):
O=C(CCl)N1Cc2ccccc2[C@H](c2cccc(F)c2)C1
COc1cccc([C@@H]2CN(C(=O)CCl)Cc3ccccc32)c1
COc1cc([C@@H]2CN(C(=O)CCl)Cc3ccccc32)c2[nH]ccc2c1
COc1cc([C@@H]2CN(C(=O)CCl)Cc3ccccc32)c2[nH]cc(CCNC(C)=O)c2c1
CC(=O)NCCc1c[nH]c2c([C@@H]3CN(C(=O)CCl)Cc4ccccc43)cc(Cl)cc12
CC(=O)NCCc1c[nH]c2c([C@@H]3CN(C(=O)CCl)Cc4ccccc43)cc(F)cc12
O=C(CCl)N1Cc2ccccc2[C@H](c2cc(F)cc3ccccc23)C1
O=C(CCl)N1Cc2ccccc2[C@H](c2cc(Cl)cc3ccccc23)C1
COc1cc([C@@H]2CN(C(=O)CCl)Cc3ccccc32)c2ccccc2c1
COc1cc([C@@H]2CN(C(=O)CCl)Cc3ccccc32)c2ccc(S(N)(=O)=O)cc2c1
COc1cc([C@@H]2CN(C(=O)CCl)Cc3ccccc32)c2ccc(CCNC(C)=O)cc2c1
N#Cc1cnc(CNC(=O)N2CCOCC2)c([C@@H]2CN(C(=O)CCl)Cc3ccccc32)c1
O=C(CCl)N1Cc2ccccc2[C@H](c2cc(F)cnc2CNC(=O)N2CCOCC2)C1
Design Rationale:
Merging of x1392 with x0305/x01249/x0195 to target S1 pocket