Submission Details

Molecule(s):
CC(C)CS(=O)(=O)N1Cc2ccc(Cl)cc2C(C(=O)Nc2cncc3ccc(C(C)(C)O)cc23)C1

MAT-POS-c88128cb-1

CC(C)CS(=O)(=O)N1Cc2ccc(Cl)cc2C(C(=O)Nc2cncc3ccc(C(C)(C)O)cc23)C1

3-aminopyridine-like Assayed Check Availability on Manifold View
CC(C)(O)c1ccc2cncc(NC(=O)C3CN(S(=O)(=O)CC4CS(=O)(=O)C4)Cc4ccc(Cl)cc43)c2c1

MAT-POS-c88128cb-2

CC(C)(O)c1ccc2cncc(NC(=O)C3CN(S(=O)(=O)CC4CS(=O)(=O)C4)Cc4ccc(Cl)cc43)c2c1

COCCN1CC(C)(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2S1(=O)=O

MAT-POS-c88128cb-3

COCCN1CC(C)(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2S1(=O)=O

3-aminopyridine-like Ordered Check Availability on Manifold View
CC(C)CN1CC(C)(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2S1(=O)=O

MAT-POS-c88128cb-4

CC(C)CN1CC(C)(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2S1(=O)=O

3-aminopyridine-like Assayed Check Availability on Manifold View
CC1(C(=O)Nc2cncc3ccccc23)CN(CC2CC2)S(=O)(=O)c2ccc(Cl)cc21

MAT-POS-c88128cb-5

CC1(C(=O)Nc2cncc3ccccc23)CN(CC2CC2)S(=O)(=O)c2ccc(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
CC1(C(=O)Nc2cncc3ccccc23)CN(CCC#N)S(=O)(=O)c2ccc(Cl)cc21

MAT-POS-c88128cb-6

CC1(C(=O)Nc2cncc3ccccc23)CN(CCC#N)S(=O)(=O)c2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CC(C)(C#N)CN1CC(C)(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2S1(=O)=O

MAT-POS-c88128cb-7

CC(C)(C#N)CN1CC(C)(C(=O)Nc2cncc3ccccc23)c2cc(Cl)ccc2S1(=O)=O

3-aminopyridine-like Check Availability on Manifold View
CC1(C(=O)Nc2cncc3ccccc23)CN(CC2COC2)S(=O)(=O)c2ccc(Cl)cc21

MAT-POS-c88128cb-8

CC1(C(=O)Nc2cncc3ccccc23)CN(CC2COC2)S(=O)(=O)c2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
CC1(C(=O)Nc2cncc3ccccc23)CN(CC2CCOCC2)S(=O)(=O)c2ccc(Cl)cc21

MAT-POS-c88128cb-9

CC1(C(=O)Nc2cncc3ccccc23)CN(CC2CCOCC2)S(=O)(=O)c2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CC1(C(=O)Nc2cncc3ccccc23)CN(CC2CCS(=O)(=O)CC2)S(=O)(=O)c2ccc(Cl)cc21

MAT-POS-c88128cb-10

CC1(C(=O)Nc2cncc3ccccc23)CN(CC2CCS(=O)(=O)CC2)S(=O)(=O)c2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CC(C)(O)c1ccc2cncc(NC(=O)C3(C)CNS(=O)(=O)c4ccc(Cl)cc43)c2c1

MAT-POS-c88128cb-11

CC(C)(O)c1ccc2cncc(NC(=O)C3(C)CNS(=O)(=O)c4ccc(Cl)cc43)c2c1

3-aminopyridine-like Ordered Check Availability on Manifold View
CC1(C(=O)Nc2cncc3ccc(F)cc23)CNS(=O)(=O)c2ccc(Cl)cc21

MAT-POS-c88128cb-12

CC1(C(=O)Nc2cncc3ccc(F)cc23)CNS(=O)(=O)c2ccc(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
CC1(C(=O)Nc2cncc3cc(F)ccc23)CNS(=O)(=O)c2ccc(Cl)cc21

MAT-POS-c88128cb-13

CC1(C(=O)Nc2cncc3cc(F)ccc23)CNS(=O)(=O)c2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
CC1(C(=O)Nc2cncc3cc(S(C)(=O)=O)ccc23)CNS(=O)(=O)c2ccc(Cl)cc21

MAT-POS-c88128cb-14

CC1(C(=O)Nc2cncc3cc(S(C)(=O)=O)ccc23)CNS(=O)(=O)c2ccc(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
CC1(C(=O)Nc2cncc3cccc(Cl)c23)CNS(=O)(=O)c2ccc(Cl)cc21

MAT-POS-c88128cb-15

CC1(C(=O)Nc2cncc3cccc(Cl)c23)CNS(=O)(=O)c2ccc(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View

Design Rationale:

Additional options for expansion on the cyclic sulfonamide and tertiary alcohol.

Discussion: