N#Cc1ccc2cncc(NC(=O)C3CCOc4ccc(Cl)cc43)c2c1
O=C(Nc1cncc2ccc(OC(F)(F)F)cc12)C1CCOc2ccc(Cl)cc21
CC(C)(O)c1ccc2cncc(NC(=O)C3CCOc4ccc(Cl)cc43)c2c1
O=C(Nc1cncc2ccc(O)cc12)C1CCOc2ccc(Cl)cc21
CS(=O)(=O)c1ccc2cncc(NC(=O)C3CCOc4ccc(Cl)cc43)c2c1
O=C(Nc1cncc2ccc(OC(F)F)cc12)C1CCOc2ccc(Cl)cc21
O=C(Nc1cncc2ccc(C(F)F)cc12)C1CCOc2ccc(Cl)cc21
O=C(Nc1cncc2c1COCC2)C1CCOc2ccc(Cl)cc21
CN1CCc2cncc(NC(=O)C3CCOc4ccc(Cl)cc43)c2C1
O=C(Nc1cncc2c1CNCC2)C1CCOc2ccc(Cl)cc21
Based on structure the 6 position of the isoquinoline seems most amenable to functionalization - the ideas here are either bulletproofing this position for metabolism, or lowering log D, or both. Note some (e.g. phenol) could preempt 2nd phase metabolism, but experience suggests this occurs on case by case basis so still worth checking experimentally.