Submission Details

EDJ-MED-c7fc9efa
Molecule(s):
O=C1NCC(C(=O)Nc2cncc3c2CCC3)c2cccc(Cl)c21

EDJ-MED-c7fc9efa-1

O=C1NCC(C(=O)Nc2cncc3c2CCC3)c2cccc(Cl)c21

3-aminopyridine-like Check Availability on Manifold View
CN1CC(C(=O)Nc2cncc3c2CCC3)c2cccc(Cl)c2C1=O

EDJ-MED-c7fc9efa-2

CN1CC(C(=O)Nc2cncc3c2CCC3)c2cccc(Cl)c2C1=O

3-aminopyridine-like Check Availability on Manifold View
O=C1NCC(C(=O)Nc2cncc3c2COC3)c2cccc(Cl)c21

EDJ-MED-c7fc9efa-3

O=C1NCC(C(=O)Nc2cncc3c2COC3)c2cccc(Cl)c21

3-aminopyridine-like Check Availability on Manifold View
CC1(C)Oc2cncc(NC(=O)C3CNC(=O)c4c(Cl)cccc43)c2O1

EDJ-MED-c7fc9efa-4

CC1(C)Oc2cncc(NC(=O)C3CNC(=O)c4c(Cl)cccc43)c2O1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

MAT-POS-199e2e7c-1 has an enzyme IC50 of 5uM which as a m-Cl phenyl acetic acid derivative is in the top quarter. These analogues should be both more potent and as or more metabolically stable.

Inspired By:
Discussion:

Contributor: Ed J Griffen, MedChemica Ltd - Tue, 22 Jun 2021 10:39:17 +0000