Submission Details

JAG-UCB-c61058a9
Molecule(s):
Cc1nnc(NC(=O)[C@@H]2COc3ccc(Cl)cc32)n1C1CC1

JAG-UCB-c61058a9-1

Cc1nnc(NC(=O)[C@@H]2COc3ccc(Cl)cc32)n1C1CC1

3-aminopyridine-like Ordered Check Availability on Manifold View
Cn1c(NC(=O)[C@@H]2CCOc3ccc(Cl)cc32)nnc1C1CC1

JAG-UCB-c61058a9-2

Cn1c(NC(=O)[C@@H]2CCOc3ccc(Cl)cc32)nnc1C1CC1

3-aminopyridine-like Check Availability on Manifold View
Cn1c(NC(=O)[C@@H]2COc3ccc(Cl)cc32)nnc1C1CC1

JAG-UCB-c61058a9-3

Cn1c(NC(=O)[C@@H]2COc3ccc(Cl)cc32)nnc1C1CC1

3-aminopyridine-like Check Availability on Manifold View
CCn1cnnc1NC(=O)[C@H]1COc2cc(Cl)ccc2C1

JAG-UCB-c61058a9-4

CCn1cnnc1NC(=O)[C@H]1COc2cc(Cl)ccc2C1

CC(C)n1ncnc1NC(=O)[C@@H]1COc2ccc(Cl)cc21

JAG-UCB-c61058a9-5

CC(C)n1ncnc1NC(=O)[C@@H]1COc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1oncc1C1CC1)[C@@H]1CCOc2ccc(Cl)cc21

JAG-UCB-c61058a9-6

O=C(Nc1oncc1C1CC1)[C@@H]1CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cnoc1C1CC1)[C@@H]1CCOc2ccc(Cl)cc21

JAG-UCB-c61058a9-7

O=C(Nc1cnoc1C1CC1)[C@@H]1CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(C[C@H]1Cc2cc(Cl)ccc2O1)Nc1nncn1C1CC1

JAG-UCB-c61058a9-8

O=C(C[C@H]1Cc2cc(Cl)ccc2O1)Nc1nncn1C1CC1

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1oncc1C1CCC1)[C@H]1CCOc2ccc(Cl)cc21

JAG-UCB-c61058a9-9

O=C(Nc1oncc1C1CCC1)[C@H]1CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(c1ncoc1C1CC1)N1CCOc2cc(F)ccc2C1

JAG-UCB-c61058a9-10

O=C(c1ncoc1C1CC1)N1CCOc2cc(F)ccc2C1

O=C(Nc1cnoc1C1CCC1)[C@@H]1CCOc2ccc(Cl)cc21

JAG-UCB-c61058a9-11

O=C(Nc1cnoc1C1CCC1)[C@@H]1CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(CN1CCOc2ccc(Cl)cc21)Nc1nncn1C1CC1

JAG-UCB-c61058a9-12

O=C(CN1CCOc2ccc(Cl)cc21)Nc1nncn1C1CC1

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cnnn1C1CC1)[C@H]1COc2cc(F)ccc2C1

JAG-UCB-c61058a9-13

O=C(Nc1cnnn1C1CC1)[C@H]1COc2cc(F)ccc2C1

CC(C)n1cc(NC(=O)[C@@H]2COc3ccc(Cl)cc32)nn1

JAG-UCB-c61058a9-14

CC(C)n1cc(NC(=O)[C@@H]2COc3ccc(Cl)cc32)nn1

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1nncn1C1CC1)[C@@H]1CCc2ccccc2O1

JAG-UCB-c61058a9-15

O=C(Nc1nncn1C1CC1)[C@@H]1CCc2ccccc2O1

CCn1cnnc1NC(=O)[C@@H]1CCOc2ccc(Br)cc21

JAG-UCB-c61058a9-16

CCn1cnnc1NC(=O)[C@@H]1CCOc2ccc(Br)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1nncn1C1CC1)[C@@H]1CCOc2ccc(Br)cc21

JAG-UCB-c61058a9-17

O=C(Nc1nncn1C1CC1)[C@@H]1CCOc2ccc(Br)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1nncn1C1CC1)[C@@H]1COc2ccc(Cl)cc21

JAG-UCB-c61058a9-18

O=C(Nc1nncn1C1CC1)[C@@H]1COc2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
O=C(Nc1nncn1C1CC1)[C@@H]1COc2ccc(Br)cc21

JAG-UCB-c61058a9-19

O=C(Nc1nncn1C1CC1)[C@@H]1COc2ccc(Br)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cnnn1C1CC1)[C@@H]1CCOc2ccc(Br)cc21

JAG-UCB-c61058a9-20

O=C(Nc1cnnn1C1CC1)[C@@H]1CCOc2ccc(Br)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1nncn1C1CC1O)C1CCOc2ccc(Cl)cc21

JAG-UCB-c61058a9-21

O=C(Nc1nncn1C1CC1O)C1CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cnnn1C1CC1)[C@@H]1CCOc2ccc(Cl)cc21

JAG-UCB-c61058a9-22

O=C(Nc1cnnn1C1CC1)[C@@H]1CCOc2ccc(Cl)cc21

3-aminopyridine-like Ordered Check Availability on Manifold View
O=C(Nc1ncn(C2CC2)n1)N[C@@H]1COc2ccc(Cl)cc21

JAG-UCB-c61058a9-23

O=C(Nc1ncn(C2CC2)n1)N[C@@H]1COc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cnnn1C1CC1)N1CCOc2ccc(F)cc2C1

JAG-UCB-c61058a9-24

O=C(Nc1cnnn1C1CC1)N1CCOc2ccc(F)cc2C1

O=C(Nc1cnnn1C1CC1)N[C@H]1CCCOc2cc(Cl)ccc21

JAG-UCB-c61058a9-25

O=C(Nc1cnnn1C1CC1)N[C@H]1CCCOc2cc(Cl)ccc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1ncn(C2CC2)n1)N[C@@H]1CCOc2ccc(Br)cc21

JAG-UCB-c61058a9-26

O=C(Nc1ncn(C2CC2)n1)N[C@@H]1CCOc2ccc(Br)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cnnn1C1CC1)[C@@H]1COc2ccc(Cl)cc21

JAG-UCB-c61058a9-27

O=C(Nc1cnnn1C1CC1)[C@@H]1COc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cnnn1C1CC1)[C@@H]1COc2ccc(Br)cc21

JAG-UCB-c61058a9-28

O=C(Nc1cnnn1C1CC1)[C@@H]1COc2ccc(Br)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cnnn1C1CC1)N[C@@H]1COc2ccc(Cl)cc21

JAG-UCB-c61058a9-29

O=C(Nc1cnnn1C1CC1)N[C@@H]1COc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1cnnn1C1CC1)N[C@@H]1CCOc2ccc(Br)cc21

JAG-UCB-c61058a9-30

O=C(Nc1cnnn1C1CC1)N[C@@H]1CCOc2ccc(Br)cc21

3-aminopyridine-like Check Availability on Manifold View
COc1ccc2c(c1)OC[C@@H]2CC(=O)Nc1nncn1C1CC1

JAG-UCB-c61058a9-31

COc1ccc2c(c1)OC[C@@H]2CC(=O)Nc1nncn1C1CC1

3-aminopyridine-like Check Availability on Manifold View
COC1CC1n1cnnc1NC(=O)C1CCOc2ccc(Cl)cc21

JAG-UCB-c61058a9-32

COC1CC1n1cnnc1NC(=O)C1CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
C[C@@H]1CN(C(=O)Nc2cnnn2C2CC2)Cc2ccccc2O1

JAG-UCB-c61058a9-33

C[C@@H]1CN(C(=O)Nc2cnnn2C2CC2)Cc2ccccc2O1

O=C(Nc1nncn1C1CC1)C1CCOc2ccc(O)cc21

JAG-UCB-c61058a9-34

O=C(Nc1nncn1C1CC1)C1CCOc2ccc(O)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1nncn1C1CC1)C1CCOc2ccc(OC3CC3)cc21

JAG-UCB-c61058a9-35

O=C(Nc1nncn1C1CC1)C1CCOc2ccc(OC3CC3)cc21

3-aminopyridine-like Check Availability on Manifold View
C=C(C(=O)C1CCOc2ccc(Cl)cc21)c1cncn1C1CC1

JAG-UCB-c61058a9-36

C=C(C(=O)C1CCOc2ccc(Cl)cc21)c1cncn1C1CC1

3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1nncn1C1CC1)C1CCOc2ccc(OCC(F)(F)F)cc21

JAG-UCB-c61058a9-37

O=C(Nc1nncn1C1CC1)C1CCOc2ccc(OCC(F)(F)F)cc21

3-aminopyridine-like Check Availability on Manifold View
O=C1CC(Oc2cc(Cl)cc3c2OCC3C(=O)Nc2nncn2C2CC2)N1

JAG-UCB-c61058a9-38

O=C1CC(Oc2cc(Cl)cc3c2OCC3C(=O)Nc2nncn2C2CC2)N1

3-aminopyridine-like Check Availability on Manifold View
O=C1CC(Cc2cc(Cl)cc3c2OCCC3C(=O)Nc2nncn2C2CC2)N1

JAG-UCB-c61058a9-39

O=C1CC(Cc2cc(Cl)cc3c2OCCC3C(=O)Nc2nncn2C2CC2)N1

3-aminopyridine-like Check Availability on Manifold View
O=C1CC(Oc2cc(Cl)cc3c2OCCC3C(=O)Nc2nncn2C2CC2)N1

JAG-UCB-c61058a9-40
Duplicate of:
BAR-COM-df4db19c-1

O=C1CC(Oc2cc(Cl)cc3c2OCCC3C(=O)Nc2nncn2C2CC2)N1

Duplicate 3-aminopyridine-like Check Availability on Manifold View
O=C(Nc1ncc(CO)o1)[C@@H]1CCOc2ccc(Cl)cc21

JAG-UCB-c61058a9-41

O=C(Nc1ncc(CO)o1)[C@@H]1CCOc2ccc(Cl)cc21

3-aminopyridine-like Check Availability on Manifold View
CCc1nocc1NC(=O)[C@H]1COc2cc(F)ccc2C1

JAG-UCB-c61058a9-42

CCc1nocc1NC(=O)[C@H]1COc2cc(F)ccc2C1

O=C(Nc1cc(C2CC2)on1)N[C@@H]1CCOc2ccc(F)cc21

JAG-UCB-c61058a9-43

O=C(Nc1cc(C2CC2)on1)N[C@@H]1CCOc2ccc(F)cc21

3-aminopyridine-like Check Availability on Manifold View
Cc1nnc(NC(=O)[C@@H]2CCOc3ccc(Cl)cc32)n1C1CC1

JAG-UCB-c61058a9-44

Cc1nnc(NC(=O)[C@@H]2CCOc3ccc(Cl)cc32)n1C1CC1

3-aminopyridine-like Ordered Check Availability on Manifold View
O=C(Nc1cc(=O)[nH]c2ccccc12)C1CCOc2ccc(Cl)cc21

JAG-UCB-c61058a9-45

O=C(Nc1cc(=O)[nH]c2ccccc12)C1CCOc2ccc(Cl)cc21

3-aminopyridine-like Assayed Check Availability on Manifold View
COc1ccc2c(NC(=O)C3CCOc4ccc(Cl)cc43)cc(=O)[nH]c2c1

JAG-UCB-c61058a9-46

COc1ccc2c(NC(=O)C3CCOc4ccc(Cl)cc43)cc(=O)[nH]c2c1

3-aminopyridine-like Check Availability on Manifold View
Design Rationale:

proposed molecules as first follow-ons to JAG-UCB-a3ef7265-20

Other Notes:

submitted by Matt of PostEra on Jag's behalp

Discussion:

Contributor: Jag Heer, UCB - Thu, 25 Jun 2020 14:40:08 +0000