Submission Details
Molecule(s):
CN1c2cccc(C(N)=O)c2N=c2cc3c(c(C(N)=O)c21)=Nc1ccccc1O3
Cn1c2cccc(C(=O)O)c2nc2ccc3c(-c4ccccc4)c(=O)[nH]c(=O)c3c21
NC(=O)c1cc(C(=O)c2ccccc2)cc2nc3c(C(=O)O)cccc3nc12
Design Rationale:
These are phenazine derivates. Phenothiazins were shown to be strong clathrin dependent endocytosis inhibitors at around 1-4 uM cc…(part of Nsp10) (If you want the reference articles I can send it here) Clathrin is part of COVID-19 membrane protein. Also there are couple of fragments of which showing some (not 100%) conformational similarity eg X-0830-0, X0820-0, X1493.